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Flashcards in CKD Deck (22):
1

What is the prevalence of CKD?

10% US

2

Is screening effective for CKD?

No

3

What are come risk factors for CKD?

DM
CVD
HTN
Hyperlipids
Obesity
Metabolic syndrome
Smoking
HIV
Hepatitis C
Malignancy

4

What are some other risk factors for CKD?

-Family HX
->60 year old
-Treatment with nephrotoxic drugs

5

What is the definition of CKD?

Kidney damage or GFR <60 for greater than 3 months

6

What are the top 3 contributors to CKD?

DM2
HTN
Glomerulonephritis

7

What is the 1st stage of CKD?

Kidney damage with GFR >90

8

What is 2nd stage of CKD?

Kidney damage with GFR of 60-89

9

What is the 3rd stage of CKD?

Moderately decreased GFR at 30-59

10

What is the 4th stage of CKD?

Severely decreased GFR at 15-29

11

What is the 5th stage of CKD?

Kidney failure at GFR <15

12

What is the definition of kidney damage?

Pathological abnormality in blood or urine tests or imaging
- UA, Urine alb, pro/Cr and serum creatinine

13

What is the best measurement of GFR?

CKD-Epi formula

14

What is plasma creatinine good for?

Simple

15

What are the limitations of creatinine?

Inaccurate with mild renal impairment
- reduced in low muscle
- increase with high protein diet
- affected by certain drugs

16

What is Cystatin C?

-Low molecular wt produced by all nucleated cells
-Not affected by diet, gender, age, muscle mass
- affected by steroids

17

What is creatinine clearance good for?

Urine collections unreliable
- overestimates GFR
-Drug influences creatinine assays

18

What is the Cockroft-Gault formula?

140-age*wt/72*Scr

-avoids urine collection
-Overestimates for obesity and low protein diet
- better than plasma creatinine for renal impairment

19

What is MDRD?

Modification of Diet in Renal Dz
- 186*Scr*age*0.742 (Females)* 1.210

20

What is CDK-EPI?

included age, sex, race and serum creatinine
- 60mL/min/1.73m^2

21

What is the best approximation of true GRF?

Plasma clearance
- invasive
-use radioisotopes

22

What is the management of CKD?

1. Treatment of reversible causes of renal dysfunction
2. Preventing or slowing progression of renal dz
3. Treatment of complication of renal dysfunction
4. Preparation and initiation of renal replacement therapy