Flashcards in Class 2 - IV Bolus Administration Deck (17):

1

## What is the simplest way to describe drug distribution and elimination?

### One-Compartment Open Model.

2

## What does the One-Compartment Open Model assume?

###
That the drug can enter and leave the body and the body acts like a single uniform compartment.

k=km + ke

3

## What is the volume of distribution?

### A hypothetical volume of body fluid that would be required to dissolve the total amount of drug at the same concentration as that found in the blood.

4

## What is the volume of distribution proportionally constant to?

###
The amount of drug in the body to the measured concentration in the biological fluid.

Vd = Db/Cp

5

## What does a Large Vd mean?

### More concentrated in extravascular tissues and less concentrated intravascularly.

6

## If a drug is highly bound to plasma proteins or remaining in the vascular region what happens to the Cp and Vd?

### Higher Cp and smaller Vd

7

## The apparent Vd is a volume term that can be expressed as a simple volume or in terms of present body weight. In expressing the apparent Vd in terms of percent body weight, a 1-L volume is assumed to be....

### equal to the weight of 1 kg

8

## What is clearance?

###
A measure of drug elimination from the body without identifying the mechanism or process.

Volume of plasma that is cleared of drug per unit time.

Cl = kVd

9

## Why do some drugs fit the multi-compartment model?

### Because some drugs distribute at various rates into different tissue groups.

10

## What are highly perfused tissue groups?

###
heart, brain, hepatic-portal system, kidney, and endocrine glands

Skin and muscle

Adipose tissue and marrow

11

## What are slowly perfused tissue groups?

### Bone, ligaments, tendons, cartilage, teeth, and hair.

12

## What is the method of residuals(feathering or peeling)?

### A procedure for fitting a curve to the experimental data of a drug when the drug does not clearly follow a one-compartment model.

13

## How is residual plasma concentration obtained?

### By subtracting the extrapolated line from observed data.

14

## What is the equation to find concentration in a multi compartment drug?

### Cp = Ae^(-at) + Be^(-bt)

15

## What is beta half-life?

### t1/2 = 0.693/t

16

## There is only one volume of distribution for multi-compartment model drugs. T/F

### False, there are several volume of distributions for multi-compartment models.

17