Class 9 Adrenal Drugs Flashcards Preview

Pnur 155 Pharmocology > Class 9 Adrenal Drugs > Flashcards

Flashcards in Class 9 Adrenal Drugs Deck (20)
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0
Q

Four causes of crushing syndrome

A

Tumor
Ectropic ATCH secreting tumor
Excessive steroid admin
ACTH dependant hyperplasia

1
Q

Define crushing syndrome

A

Hypersecretion of adrenocortical hormones that results in redistribution of body fat from arms and legs into face, shoulders and trunk

2
Q

Crushin syndrome can lead to

A

Potassium loss

  • increased water retention
  • muscle weakness
3
Q

Define Addison’s disease

A

Hypo secretion of adrenocortical hormones that’s associated with:

  • decreased blood sodium and glucose
  • increased potassium levels
  • dehydration
  • weight loss
4
Q

Two adrenal gland disorders

A

Crushing syndrome

Addison’s disease

5
Q

Two parts of the adrenal gland

A

Adrenal cortex

Adrenal medulla

6
Q

Adrenal cortex secretes what

A

Corticosteroids

  • glucocorticoids
  • mineralcorticoids
7
Q

Adrenal medulla secretes what

A

Catecholamimes

  • epinephrine (adrenaline)
  • norepinephrine
8
Q

Example of a mineralcorticoid

A

Aldosterone

9
Q

Function of aldosterone

A

Maintain normal levels of sodium in the blood by causing sodium to be reabsorbed from urine into blood in exchange for hydrogen and potassium

10
Q

Functiom of glucocorticoids

A
Anti inflammatory effects
Carb and protein metabolism
Fat metabolism
Maintenance of bp
Stress effects
11
Q

Function of mineralcorticoids

A

Bp control
Maintenon of ph blood levels
Maintenence of serum potassium lvls
Sodium and water reabsorption

12
Q

Process during hypovelemic crisis

A

1) Body starts to bleed out
2) body secretes renin
3) renin converts angiotensin 1 to angiotensin 2

Effects:

  • vasoconstriction
  • secretion of aldosterone to increase sodium and water reabsorption
13
Q

Four classifications of adrenal drugs

A

Natural or synthetic
Method of administration
Salt water retention potential
Duration of action

14
Q

Example of topical glucocorticoids

A

Hydrocortisone

16
Q

Example of inhaled glucocorticoids

A

Budesonide

17
Q

Mechanisms of action for mineralcorticoids

A

Effects fluid electrolyte balance by promoting sodium reabsorption from nephron into blood which pulls water with if

Promotes potassium and hydrogen excretion from exchange with sodium

18
Q

Actions of glucocorticoids

A
  • Fluid and sodium retention
  • Decreased inflammatory and immune response
  • decreased fever
  • increased breakdown of proteins for energy
  • increased production of glycogen
  • increased response to norepinephrine in smooth muscle
19
Q

Contraindicstioms for adrenal drugs

A
  • Allergy
  • Cataracts or glaucoma
  • Peptic ulcer disease
  • Mental health problems
  • Diabetes
  • Pts with infections d/t immunosuppressant effects
26
Q

Examples of systemic glucocorticoids

A

Cortisone
Dexamethasone
Prednisone