Class II Antiarrhythmics

Question 0

Propanolol toxicity?

Answer 0

Anaphylaxis

Question 1

What are the cardiac effects of Propanolol?

Answer 1

Blocks Beta1 and Beta2 receptors:
Decreased HR, contractility, BP, O2 demand
Decrease portal blood flow

Question 2

Therapeutic use of propanolol?

Answer 2

Hypertension
Angina pectoris
Supraventricular arrhythmias
Ventricular tachycardia
Prevent MI

Question 3

What are the cardiac effects of Esmolol?

Answer 3

Brief cardiac Beta blockade, preferentially B1 over B2

Decrease nodal rate, increase AV nodal rate, increase PR interval

Question 4

Extracardiac effects of esmolol?

Answer 4

Hypotension, blurred vision, confusion, increased sweating, tiredness

Question 5

Toxicity of esmolol?

Answer 5

Bradycardia and hypotension

Question 6

Therapeutic use of Esmolol?

Answer 6

Short acting.
Controlling supraventricular/ ventricular arrhythmias, arrhythmias associated with thyrotoxicosis, preoperative hypertension, and MI

Question 7

What are the cardiac effects of acebutolol?

Answer 7

Block beta1 receptors and not beta2 receptors (except at high doses)
Establishes membrane stabilizing and intrinsic sympathomimetic activity

Question 8

What are the indications for acebutolol?

Answer 8

Hypertension, ventricular arrhythmias

Question 9

What are the cardiac effects of sotalol?

Answer 9

Prolong QT interval
Increase AP duration, decrease SA node and AV node rate/conduction
Nonselective Beta blocker

Question 10

Side effects of sotalol?

Answer 10

Bradycardia and fatigue

Question 11

Pharmacokinetics of sotalol?

Answer 11

100% bioavailability, excreted unchanged

Question 12

Indications for sotalol?

Answer 12

Suppress atrial and ventricular arrhythmias

Prevent recurrence of A fib and V tac