Classification of cancer chemotherapy

Question 1

Alkylating agent

Answer 1

Binds DNA, inducing cell death, inhibiting cell proliferation
e.g. cyclophosphamide

Question 2

Platinum-based drugs

Answer 2

Binds DNA

e.g. cisplatin

Question 3

Antimetabolites

Answer 3

Inhibit DNA synthesis = S-phase specific

e.g. methotrexate

Question 4

Topoisomerase-interactive drugs

Answer 4

Inhibit topoisomerases

e.g. doxorubicin

Question 5

Antimicrotuble drugs

Answer 5

Bind microtubules = M-phase specific

e.g. paclitaxel

Question 6

Hormonal agents

Answer 6

Block production or action of sex steroids

e.g. tamoxifen

Question 7

Targeted therapies

Answer 7

Block oncogenic proteins

e.g. imatinib

Question 8

Vascular targeting therapies

Answer 8

Inhibit angiogenesis

e.g. bevacizumab