Clinical approaches to hypoglycaemia Flashcards
How is hypoglycaemia defined?
Hunger, anxiety, fatigue, low mood, tremulousness
Level 1 - glucose value lower than 4 mmol/L (‘four is floor’)
Level 2 -
Level 3 -
How often does hypoglycaemia happen?
Why would hypoglycaemia occur?
Who is most at risk of hypoglycaemia?
What are the different ‘types’ of hypoglycaemia?
What are consequences of hypoglycaemia?
Hypoglycaemia is pro-inflammation
What are diabetic related risk factors for severe hypoglycaemia?
What are counterregulatory failures associated in T1DM?
Mechanism of glucose counterregulation is compromised in T1DM, glucagon counterregulation is compromised in T1DM, catecholamines are suppressed in T1DM (as a result of adaptating thresholds for hypoglycaemia detection)
What patient groups are particularly at risk for severe hypoglycaemia?
Hba1c doesn’t really show hypoglycaemic risk
yes
What is the relationship between catecholamines and blood glucose?
Catecholamines and a number of other hormones released during stress states contribute to the development of hyperglycemia by directly stimulating glucose production and interfering with tissue disposal of glucose
Describe ‘double-hit of hypoglycaemia’ in the context of exercise, insulin and T1DM.
What are clinical factors associated with hypoglycemia (precipitants, risk factors, co-morbidities)?
