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Medical Pharmacology Exam 2 > Clinical Aspects of Cancer Chemotherapy > Flashcards

Clinical Aspects of Cancer Chemotherapy Flashcards

1
Q

Regarding chemotherapy, define induction

A

First round of therapy

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2
Q

Regarding chemotherapy, define adjuvant.

A

Chemo given post - surgery

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3
Q

Regarding chemotherapy, define neoadjuvant

A

Chemo given pre - surgically

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4
Q

Regarding chemotherapy, define salvage

A

Chemo given as second or third round

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5
Q

What are the 2 examples of bifunctional alkylators provided as examples?

A

Ifosfamide and chlorambucil

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6
Q

Carmustine, lomustine, busulfan, dacarbazine, procarbazine. These all belong to what class of drugs _

A

Alkylators

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7
Q

In addition to daunorubicin and doxorubicin, the third example of an antitumor antibiotic provided was?

A

Dactinomycin

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8
Q

In addition to vincristine, vinblastine and paclitaxel, the fourth example of a mitotic spindle poison provided was _

A

Docetaxel

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9
Q

Regarding cyclophosphamide, what enzymes are responsible for its activation? What about its inactivation? What are the 2 products of its metabolism that are toxic?

A

Hepatic CYP 450s
Aldehyde dehydrogenase
Acrolein and phosphoramide mustard

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10
Q

What is the major site of metabolism of the anthracyclines and the vinca alkaloids? What about cisplatin?

A

Anthracycline and vincas - Liver

Cisplatin - Kidney

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11
Q

What are 2 specific toxicities associated with vincristine?

A

peripheral neuropathy

SIADH (syndrome of inappropriate antidiuretic hormone (ADH) secretion)

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12
Q

What is a specific toxicity associated with paclitaxel?

A

Neuropathy

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13
Q

What are 3 specific toxicities associated with bleomycin?

A

Pulmonary fibrosis
Fever
Anaphylaxis

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14
Q

What are 2 specific toxicities associated with methotrexate?

A

Renal dysfunction

Hepatic dysfunction

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15
Q

What is a specific toxicity associated with 5-fluorouracil?

A

Diarrhea

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16
Q

What are 2 specific toxicities associated with cytosine arabinoside?

A

Cerebellar dysfunction

Fever

17
Q

What are 2 specific toxicities associated with cyclophosphamide?

A

Hemorrhagic cystitis

SIADH - like syndrome

18
Q

What is a specific toxicity associated with bisulfan?

A

Pulmonary fibrosis

19
Q

What is a specific toxicity associated with cisplatin and carboplatin?

A

Renal failure

20
Q

What is a specific toxicity associated with the anthracyclines?

A

Cardiomyopathy

21
Q

What is a specific toxicity associated with alkylating agents?

A

Secondary cancers

22
Q

What is a specific toxicity associated with irinotecan? How can this be prevented? Accumulation of what metabolite causes this diarrhea?

A

Diarrhea
Atropine premedication, blocks muscarinic agonism
SN38 (glucuronide)

23
Q

A common ending to the names of the tyrosine kinase inhibitors is _

A

-ib

24
Q

What is the exception to the rule that majority of chemotherapeutic agents are myelosuppressive?

A

Vincristine

Medical Pharmacology Exam 2 (16 decks)

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