Clinical - Glomerular Disease Flashcards
(35 cards)
What is a urinary albumin excretion of 30-300 mg/1.7m/24 hrs?
Microalbuminuria
What is a urinary albumin excretion more than 300 mg/1.7m/24 hrs?
Overt proteinuria
What s the urinary protein value of nephrotic syndrome?
Urinary protein greater than 3.5g/1.73m/24hrs
What are the findings in nephrotic syndrome?
Hypoalbuminemia, peripheral edema, hypercholesterolemia, lipiduria (maltese crosses)
What is the thrombotic complication of nephrotic syndrome?
Renal vein thrombosis
How is the urine in nephritic syndrome?
Oliguria, proteinuria, urinary sediment with dysmorphic RBC
cola or smoky appearance
How is the urine in nephrotic syndrome?
Hypoalbuminemia, hypercholesterolemia, lipiduria (maltese crosses)
What bacteria causes post streptococcal glomerulonephritis
Group A beta hemolytic streptococci
What glomerular changes are associated with post streptococcal glomerulonephritis
Hypercellularity of the glomerular tufts
Subepithelial humps
Starry sky, mesangial, garland
What are the clinical findings in IgA nephropathy (Berger disease)
Microscopic hematuria and proteinuria
What is seen on light microscopy in IgA nephropathy
Mesangial expansion
What is seen on immunofluoresence in IgA nephropathy
Strong IgA staining with in the mesangium
How does Henock-Shonlein purpura present?
Microscopic or gross hematuria
RBC cast, purpura, abdominal pain
How does membranoproliferative glomerulonephritis present
Hematuria, proteinuria, nephritic syndrome
What are the lab findings of membranoproliferative glomerulonephritis
Proliferation of mesangium and thickening of glomerular capillary wall
How do you treat membranoproliferative glomerulonephritis
Long term corticosteroid therapy
What is rapidly progressive glomerulonephritis
Deterioration of renal function with active urinary sediment
Crescentic glomerulonephritis
What is wegeners granulomatosis
Granulomatous inflammation involving respiratory tract and vasculitis affecting small and medium sized vessels
What is polyarteritis nodosa vasculitis
Necrotizing inflammation of medium sized or small arteries without glomerulonephritis or vasculitis
What organ system is involved in Goodpastures
pulmonary renal
What antibodies are involved in Goodpastures
Circulating anti-GBM antibodies
What is minimal change nephropathy
Absence of structural glomerular abnormalities except epithelial cell foot processes seen on electron microscopy
What is the treatment of minimal change nephropathy
High dose corticosteroids
What are the clinical features of membranous nephropathy
Autoantibodies to the M-type phospholipase A2 receptor
Proteinuria
Subepithelial deposits along GBM
