Clinical Implications (rebby) Flashcards

(92 cards)

1
Q

4D’s of Brainstem Dysfunction

A

Dysphagia
Dysarthria
Diplopia
Dysmetria

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2
Q

Blockage of PCA or Basilar artery causes ________ Syndrome

A

Anteromedial Midbrain Syndrome (Weber’s)

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3
Q

Patient presents with
* CL hemiparesis
* IL loss of eye movements, paralysis of eyelid, dilated pupil
* CL loss of motor coordination, Lability, Ataxia

What are the primary structures affected? What is the syndrome?

A
  1. Corticospinal Tract
  2. Oculomotor Nerve Nucleus
  3. Red Nucleus

Anteromedial Midbrain Syndrome (Weber’s)

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4
Q

What are 2 symptoms of CN III palsy?

A
  1. Ptosis (droopy eyelid)
  2. Eye deviated down and out
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5
Q

Blockage of AICA leads to ________________ Syndrome

A

Lateral Inferior Pontine Syndrome

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6
Q

Patient presents with
* IL hearing loss
* Dysequilibrium
* IL horner’s syndrome
* IL facial pain
* Decreased tears & salivation
* CL pain and temp sensation lost
* IL weakness of facial expressions

What is the syndrome?

A

Lateral Inferior Pontine syndrome

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7
Q

Name the 7 primary structures affected with Lateral Inferior Pontine Syndrome

A
  1. Cochlear Nucleus
  2. Vestibular Nucleus
  3. Impaired sympathetics
  4. Trigeminal Nerve
  5. Salivatory Nucleus
  6. Spinothalamic Tract
  7. Facial Nerve
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8
Q

Bell’s Palsy is damage to what CN?

A

CN VII

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9
Q

Horner’s Syndrome is what 3 things?

A

Ptosis-eyelid drooping
Miosis-excessive constriction
Anhidrosis- little/no sweat

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10
Q

Thrombosis or stenosis of basilar artery will affect ________ bilaterally and cause ________ syndrome

A

Ventral Pons

Locked-In Syndrome

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11
Q

Patient presents with
* Paralysis below the head
*Paralysis of facial, swallowing, chewing, talking muscles
* inability to abduct eyes

What structures are affected?

A

B corticospinal tracts
B corticobulbar tracts
B abducens nerve nuclei

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12
Q

Which of the following is not affected in Lateral Inferior Pontine Syndrome?

A. Vestibular Nucleus
B. Impaired sympathetics
C. Vagus Nerve nucleus
D. Salivatory Nucleus

A

C. Vagus Nerve nucleus

this is a primary affected structure in Wallenberg Syndrome

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13
Q

Which of the following is not affected in both Lateral Inferior Pontine syndrome and Wallenberg?

A. Solitary Nucleus
B. Salivatory Nucleus
C. Trigeminal Nerve
D. Spinothalamic Tract

A

A. Solitary Nucleus

only in Wallenberg

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14
Q

Blockage of Anterior Spinal Artery leads to ______ Syndrome

A

Medial Medullary Syndrome

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15
Q

Patient presents with
* IL tongue protrusion
*CL loss of vibration, proprioception, light touch
*CL hemiparesis

What structures are affected? What is the syndrome?

A

Hypoglossal Nucleus
DCML
Pyramids

Medial Medullary Syndrome

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16
Q

Blockage of PICA leads to _____ Syndrome

A

Wallenberg/Lateral Medullary Syndrome

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17
Q

Which of the following is not a clinical manifestation of Wallenberg Syndrome?

A. Increased HR
B. Ataxia
C. Horner’s syndrome
D. Can’t abduct eyes

A

D. Can’t abduct eyes

this is a manifestation of Locked In syndrome –> B abducens

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18
Q

In the thalamus, when relay sensory neurons disrupt CONTRALATERAL sensation, what sensation is most commonly affected?

A

Proprioception

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19
Q

What is a common clinical implication of a thalamic lesion?

A

Lateropulsion aka Pusher syndrome aka Contraversive Pushing

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20
Q

In Pusher Syndrome, does the patient push to the strong or weak side?

A

Weak side

Push with strong side towards the weaker side & accompanied by POSTERIOR push

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21
Q

What type of tumor makes up 10-17% of intracranial neoplasms? (in hypothalamus)

A

Pituitary adenomas

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22
Q

Larger pituitary adenomas can push on surrounding structures (of the hypothalamus) such as _______ _______ and cause _______ _______

A

Optic chiasm

Bitemporal hemianopsia

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23
Q

When there is too much Basal Ganglia inhibition of motor thalamus, PPN, and midbrain locomotor region, this will cause __________

A

Hypokinesia

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24
Q

In Parkinson’s, there is ______ (decreased/increased) dopamine from SNc leading to ________ (under/over) activity of GPi

A

Decreased

Over

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25
fill in the blank with (overactivity/underactivity) Overactivity of GPi in Parkinson's leads to _______ in motor thalamus
Underactivity (bradykinesia and hypokinesia)
26
fill in the blank with (moreinhibition/less inhibition) Overactivity of GPi in Parkinson's leads to _______ in Pedunculopontine nucleus
Less inhibition (rigidity trunk and girdle muscles)
27
fill in the blank with (overactivity/underactivity) Overactivity of GPi in Parkinson's leads to _______ in Midbrain locomotor region
Underactivity (freezing and festinating gait)
28
What are the 2 subtypes of Parkinson's?
Postural Instability Gait Difficulty Tremor Dominant Subtype
29
When there is too *little* Basal Ganglia inhibition, that causes ________
Hyperkinetic disorders
30
In hyperkinetic disorders, there is (more/less) inhibition by the GPi
Less inhibition because
31
Hyperkinetic disorders affect _____ (which motor pathway)
No-Go/Indirect pathway
32
In hyperkinetic disorders, there's a _____ of inhibitory neurons in putamen and caudate, so ____ input to GPe
Loss Less (inhibitory) So GPe inhibits Subthalamic Nucleus (MORE) which excites GPi less so GPi has less inhibition
33
Dystonia increases with _____ and decreases/completely vanishes with ____
Activity and/or emotional stress Sleep
34
Injury to Paramedian Pontine Reticular Formation (PPRF) causes loss of
Horizontal Gaze center
35
Injury to Rostral interstitial nucleus in midbrain RF causes loss of
Vertical Gaze Center
36
Injury to Medial Longitudinal Fasciculus causes loss of
coordinated activation of B neural circuits
37
Injury to Vestibular n will cause loss of which 2 reflexes?
VOR and Optokinetic Reflex
38
Injury to Frontal eye field will cause loss of CL _______ and ________, and loss of connection with CL ________
saccades, smooth pursuit PPRF
39
Injury to Parieto-occipital-temporal cortex will cause loss of (CL/IL) smooth pursuit
IL whereas frontal eye field does CL smooth pursuit and saccades
40
Injury to Parieto-occipital-temporal cortex may affect the cortex *connection* to what 3 locations?
vestibular nucleus cerebellum PPRF
41
Lesion to superior colliculus (optic tectum) causes
Increased latency and reduced accuracy, frequency, and velocity of saccades
42
How will injury to basal ganglia affect the visual system?
Deficits in initiation of eye movements
43
How will injury to cerebellum affect the visual system?
Deficits in correct execution of eye movements
44
Lesion to L optic nerve
Loss of vision to L eye
45
Lesion to optic chiasm
Bitemporal (heteronomous) hemianopsia
46
Lesion to L optic tract
R homonymous hemianopsia
47
Lesion to L Meyer's Loop
R superior homonymous quadrantanopsia
48
Lesion to L V1
R homonymous hemianopsia with macular sparing
49
Lesion to primary auditory cortex causes
Loss of conscious hearing
50
Lesion to secondary auditory cortex results in ...
Inability to compare sounds with memories of sounds and categorize them
51
How will a lesion to superior colliculus affect the auditory system?
Inability to orient head and eyes toward sound
52
Lesion to Wernicke's area means...
Inability to comprehend speech
53
If SCC signals are not reciprocal, there is impaired ______, ______, and/or ______
Postural control Eye movements Nausea
54
When the pt has a vestibular disorder, _____ is essential for adaptations in postural/balance systems
Vestibulocerebellum
55
Lesion of R posterior parietal cortex causes _______
Altered perceptions of personal and extrapersonal space L hemi neglect
56
Lesion to descending pathway of vestibular system...
Balance deficits --> impacts movement abilities/control especially in low-light or uneven surface conditions
57
Vestibular + visual systems linked for ....
Postural control & eye movements
58
Vestibular + auditory systems linked due to....
Geography and sharing same CN
59
T/F: Cerebellar dysfunction causes abnormal muscle strength and tone
False
60
If cerebellar dysfunction DOES cause abnormal tone, it is hypo/hyper
Hypotonia
61
Lesion to any/all areas in cerebellum causes ______
Ataxia: jerky, uncoordinated movements of trunk/neck, limbs
62
Lesion to vestibulocerebellum causes
**Nystagmus**: bouncy eye movements & Unsteadiness, truncal ataxia, dysequilibrium
63
Lesion to cerebrocerebellum causes
Ataxic finger movements & Dysarthria: slurring of speech
64
Lesion to spinocerebellum causes
Dysarthria Explosive Speech Limb ataxia * Dysdiadochokinesia * Dysmetria (ACTION & INTENTION TREMOR) Loss of check/rebound Movement decomposition
65
What is problem with rapid alternating movements?
Dysdiadochokinesia
66
What is tendency to under/overshoot when moving to a target?
Dysmetria
67
What is shaking of limb during movement called?
Action tremor
68
What tends to occur due to delays in agonist burst of activity + in antagonist's ability to brake?
Intention tremor
69
What is it called when there is a quick removal of resistance that causes an exaggerated response?
Loss of check/rebound
70
What is it called when you attempt to move one joint at a time?
Movement decomposition
71
What is loss of joint position sense?
Sensory ataxia DCML disruption & can improve with visual aid
72
What is an agnosia?
Despite having intact vision or hearing, inability to recognize object or sound
73
Agnosia is a disorder of ____ visual stream
Ventral
74
Prosopagnosia is ...
Inability to recognize faces visually
75
Disorder of secondary auditory cortex
Auditory agnosia = can't associate meaning to what you hear
76
Anosagnosia is ...
Inability to recognize deficits a reasoning problem
77
Disorder of secondary somatosensory cortex
Astereognosia = even with intact light touch sensation, can't describe object in hand
78
Optic ataxia is a disorder of ____ visual stream
Dorsal
79
Optic ataxia is ...
an inability to use visual info to direct movements
80
Damage to PPC causes
Hemineglect
81
Right or Left Hemineglect is more common
Left neglect due to Right hemispheric lesion
82
Damage to primary motor cortex leads to ____, ____, and _____
Loss of fractionated movements Weakness Dysarthria
83
Lesion to supplementary motor area (acute & long term)...
Acutely: hemiparesis, hemiplegia Long term: anti-phase hand movements anti-phase is when muscles contract in alternating fashion (aka hands moving to same side so opposite muscles on each arm are contracting)
84
Lesion to premotor cortex causes issues with _____, _____, and _______
Speech and automaticity of reaching/grasping Movement sequences Posture (axial control) and gait
85
Damage to inferior frontal gyrus can cause...
Broca's Aphasia can be included here (motor of speech)
86
Damage to motor planning areas causes **preservation**. What is that?
Uncontrolled repetition of movement/speech Remember: Mr. Egg story and how he could not put down his poached egg
87
What is **apraxia**?
Motor planning deficits
88
What is magnetic gait?
when the patient has difficulty lifting up their feet and so they have a shuffle or festinating gait
89
What is Ideational apraxia?
Inability to use objects appropriately, esp when sequence is necessary
90
What is Ideomotor apraxia?
Inability to develop movement sequence, esp to command or to mimic activity but can do it automatically
91
If someone has true apraxia, how would you describe their gait?
Magnetic gait
92
What are the 4 A's for cerebral cortex disorders?
**Aphasia**: language/communication disorder **Apraxia**: motor planning deficits **Agnosia**: can't identify sound/sight **Astereognosis**: can't describe object in hand