Clinical Pharmacology

Question 1

CYP450 Inducers

Answer 1

Rifampicin
St Johns Wort
Carbamezapine
Phenytoin

Question 2

CYP450 Inhibitors

Answer 2

Azoles
Ritonavir
Cimetidine

Question 3

Warfarin metabolism

Answer 3

CYP2C9 largely

CYP3A4 contributes

Question 4

CYP2C9 inhibitors

Answer 4

Omeprazole
Metronidazole
Cimetidine
Amiodarone

Question 5

Volume of distribution

Answer 5

Volume of drug given/Serum concentration

Question 6

Half Life

Answer 6

T1/2 = (VdL/Kg * 0.7)/Clearance

Question 7

Clearance L/min

Answer 7

Clearance L/min = (VdL/Kg * 0.7)/Half Life

Question 8

Dosing in patient with renal impairment where fraction excreted unchanged is provided

Answer 8

(Dose RP/Dose NP) = (1-FU)+FU(Renal function RP/Renal Function NP)

Question 9

Zero Order Kinetics

Answer 9

“Same amount of drug eliminated per unit time” Amount of drug that is eliminated is a constant quantity

Question 10

First Order Kinetics

Answer 10

“Same proprotion of drug eliminated per unit of time”

Amount of drug that is eliminated is a constant proportion

Question 11

CYP3A4 substrates

Answer 11

Cyclosporin
Warfarin
Quninidine
Terfenedine
Carbimazepime
Lovastatin
Methyprednisolone 
?Dabigatran

Question 12

CYP 3A4 inhibitors (Increased action of substrate)

Answer 12

Erythromycin
Azoles
Verapamil
Diltiazem

Question 13

CYP2D6 substrates

Answer 13

Codeine –> Morphine

Perhexeline

Question 14

CYP2D6 inhibitors

Answer 14

Quinidine
Neuroleptics
Fluoxetine

Question 15

Steady State Concentration

Answer 15

Steady State Concentration = (Bioavailability*dose)/Dosing interval