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Systems: Specialities AB > Clinical Pharmacology: Complementary Medicine > Flashcards

Clinical Pharmacology: Complementary Medicine Flashcards

1
Q

What is CAM?

A

The World Health Organisation defines complementary and alternative medicine (CAM) as:
-A ‘broad set of health care practices that are not part of that country’s own tradition and are not integrated into the dominant health care system’.

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2
Q

Why can interpreting what constitutes CAM be very complex?

A

National, cultural, and ethnic differences, together with the extensive and expanding list of complementary and alternative medicines, make interpretation of what constitutes CAM very complex

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3
Q

Give examples of CAM

A

-Herbal remedies
-Homeopathic therapies
-Chinese medicine
-Acupuncture
-Aromatherapy
-Reiki
-Shiatsu
-Yoga
-Hypnosis
-Meditation
-Reflexology
-Osteopathy
ETC.

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4
Q

What are CAM approaches generally not supported by?

A
  • Robust efficacy, effectiveness or safety data

- No way to report adverse events or reactions

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5
Q

What high risk patient groups are at particular risk due to the lack of safety data for CAMs?

A
  • Children
  • Pregnancy: teratogenesis and fetogenesis
  • Patients using prescribed medication
  • Polypharmacy
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6
Q

What concerns are there about CAMs?

A
  • Implausibility of most therapies
  • Lack of evidence for benefit
  • Lack of safety data
  • Evidence of harm
  • Adverse Effects / Herb-Drug Interactions
  • Unqualified practitioners / Missed diagnoses
  • Stopping conventional medicine
  • Cost-effectiveness?
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7
Q

Who uses CAMs?

A
  • 80% of the UK population
  • 60% of all cancer patients use or have used CAM
  • 60% of all pregnant women in the UK use CAM
  • 1% of children under 1 year of age are prescribed
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8
Q

Who is the typical CAM user?

A

Someone who is affluent and educated with family or friends who have used them

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9
Q

Why do people turn to CAMs?

A
  • Desire to have personal control over one’s own health.
  • Dissatisfaction with conventional treatment
  • Perception that conventional medicine lacks/disregards an holistic approach.
  • Concerns about the side effects of prescribed medications
  • Believe alternatives more congruent to their own beliefs and values
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10
Q

Why do people use CAMs?

A
  • Think they are safe and natural
  • Chronic symptom control
  • Hype
  • Holistic
  • Promotion of health
  • Relatives use CAMs
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11
Q

Why do healthcare professionals recommend CAMs?

A
  • Patient demand
  • Placebo effect
  • Genuine belief in a therapy
  • Experience -Seeing is Believing
  • “Feel good” factor in terminal illness, distressing hospital experiences
  • Use CAM themselves
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12
Q

What are herbal medicines?

A
  • Herbal medicines include herbs, herbal materials, herbal preparations and finished herbal products, that contain as active ingredients parts of plants, or other plant materials, or combinations.
  • In the UK some herbal products are classified as food supplements or cosmetics and others as medicines
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13
Q

What herbal supplements are most commonly implicated in drug reactions with breast cancer drugs?

A
  • Soya
  • Cranberry
  • Echinacea
  • Glucosamine
  • Grapefruit
  • Garlic
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14
Q

What supplements do breast cancer patients tend to use?

A

1/3 report use of supplements with oestrogenic activity

  • Soya
  • Evening primrose
  • Chamomile
  • Garlic
  • Black cohosh
  • Red clover
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15
Q

How common is it for CAMs to be used in early pregnancy?

A
  • 2/3 of women use CAM during early pregnancy.
  • 28 different CAM modalities.
  • Herbal products are the most common (37% of women),
  • 25 different herbal products used.
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16
Q

How common is it for CAMs to be used in late pregnancy?

A
  • 2/3 of women use CAM.
  • A total of 30 different CAM modalities.
  • Oral herbal products the most common (38% of respondents)
  • 40 different products.
17
Q

Why is it important to know if someone who is pregnant is using CAMs?

A
  • No safety or efficacy data
  • Teratogenesis
  • Fetogenesis
  • Drug-Herb Interactions
18
Q

How much do we know about the efficacy of herbalism?

A
  • Very little evidence
  • There has been some very specific trials
  • Little current NHS use
19
Q

How much doe know about the safety of herbalism?

A
  • Contamination, adulteration and misidentification of herbal remedies.
  • Variation between the labelled content of products and their actual content.
  • Serious toxic effects from some.
  • Biggest problem is lack of data.
  • Drug-herb interactions are a major concern, esp St John’s Wort and multiple herbs with warfarin.
20
Q

What is homeopathy?

A

Belief that minute concentrations of a particular toxin could cure the very same symptoms it would cause in large doses

21
Q

How are homeopathic remedies made?

A
  • Repeated dilutions

- Dilution level is printed on the bottle of medicine

22
Q

What are the healing powers of homeopathy attributed to?

A

‘Water memory’

The concept that water has the ability to remember the shape of the medicine it once contained

23
Q

What do we know about the efficacy of homeopathy?

A
  • Scientifically implausible.
  • Major issues with quality of studies.
  • No convincing evidence.
  • “Now doctors need to be bold and honest with their patients about homeopathy’s lack of benefit, and with themselves about the failings of modern medicine to address patients’ needs for personalised care.”
24
Q

What do we know about the safety of homeopathy?

A
  • Homeopathy is generally regarded as safe and harmless.
  • Rarely reports of adverse effects, including aggravation of symptoms, have been made.
  • Missed diagnosis
  • Inappropriate treatment
  • Adulteration
25
Q

What is acupuncture?

A
  • Based on traditional Chinese medicine it uses needles at trigger points to deal with pain
  • Vital force called “Qi” which circulates along channels called meridians.
  • There are 12main meridians, and these correspond to 12major functions or “organs” of the body.
  • Balance of “yin” and “yang”.
26
Q

How is acupuncture carried out?

A
  • 4 -10points are needled during a session.
  • Needles are left in place for 10-30minutes, although can be shorter.
  • Needles may be stimulated by twirling or an electrical current.
  • A typical course of treatment for a chronic condition would be 6-12 sessions over 3 months. This might be followed by ‘top up’ treatments
27
Q

What do we know about the efficacy of acupuncture?

A
  • Partially explicable within conventional physiology of pain.
  • Stimulates pain fibres entering the dorsal horn of the spinal cord. These cause inhibition of pain impulses.
  • Stimulate release of endogenous opioids and other neurotransmitters such as serotonin.
  • Some research evidence that acupuncture has effects greater than sham treatment or placebo in pain, but little evidence for use in other conditions.
28
Q

What do we know about the use of acupuncture in back pain?

A
  • For chronic low-back pain, acupuncture is more effective for pain relief and functional improvement than no treatment or sham treatment immediately after treatment and in the short-term only.
  • Acupuncture is not more effective than other conventional and “alternative” treatments.
  • The data suggest that acupuncture and dry-needling may be useful adjuncts to other therapies for chronic low-back pain.
29
Q

What do we know about the use of acupuncture for stroke?

A
  • Acupuncture appeared to be safe but without clear evidence of benefit.
  • The number of patients is too small to be certain whether acupuncture is effective for treatment of acute ischaemic or haemorrhagic stroke.
  • Larger, methodologically-sound trials are required.
30
Q

What do we know about the use of acupuncture in epilepsy and asthma?

A
  • The current evidence does not support acupuncture as a treatment for epilepsy. Much larger high quality clinical trials employing appropriate controls are needed.
  • There is not enough evidence to make recommendations about the value of acupuncture in asthma treatment. Further research needs to consider the complexities and different types of acupuncture.
31
Q

What do we know about the safety of acupuncture?

A

Prospective studies suggest incidence of harm is rare (14per 10000 consultations).

Serious problems similar to any harm with needle use.

  • Infection
  • Pneumothorax
  • Pneumopericardium
  • Organ puncture

Related to training of therapist

32
Q

What is aromatherapy?

A
  • Aromatherapy is the use of concentrated essential oils extracted from herbs, flowers, and other plants to treat diseases.
  • It is commonly administered by massaging into the skin.
33
Q

How can aromatherapy be administered?

A
  • Inhalation
  • Massage
  • Diffusion
  • Hot or cold compress
  • Soaking baths
34
Q

In what ways can aromatherapy be harmful?

A

-Skin irritation with frequent use
-Photosensitivity-Avoid prolonged exposure to the sun,
-Excessive inhalation can cause headaches and fatigue;
-Insomnia -peppermint,
-Origanum, sage, savory, thyme, and wintergreen, are not safe for home use.
-Skin irritation -basil, lemon grass, fennel, rosemary, and verbena
-Bronchial spasms, and people with asthma should not use
-Abortifacient- Avoid aromatherapy during pregnancy
sage, rosemary, juniper.

35
Q

What oils should not be used in pregnancy?

A
  • Aniseed
  • Basil ct estragole
  • Birch
  • Camphor
  • Hyssop
  • Mugwort
  • Parsley seed or loaf
  • Pennyroyal
  • Sage
  • Tansy
  • Tarragon
  • Thuja
  • Wintergreen
  • Wormwood
36
Q

What do we know about the efficacy of aromatherapy?

A
  • Aromatherapy is generally regarded as being relatively safe and pleasant
  • However, there is not data to support any legitimate clinical indications for the use
37
Q

How can aromatherapy affect cancer symptoms?

A
  • Massage and aromatherapy massage confer short term benefits on psychological wellbeing
  • Effect on anxiety supported by limited evidence.
  • Effects on physical symptoms may also occur.
  • Evidence is mixed as to whether aromatherapy enhances the effects of massage. Replication, longer follow up, and larger trials are need to accrue the necessary evidence.
38
Q

How are CAMs regulated in the UK

A

Homeopathy can be registered under Simplified Scheme 1992 or National Rules Scheme 2006.

  • Demonstrate quality and safety.
  • If want to have an indication and make any claim of efficacy – National Rules with evidence.
39
Q

What do doctors need to know in regards to CAM use?

A
  • Be aware of what is available via complementary practitioners, on-line and over the counter.
  • Ask patients about CAM use, as may not disclose.
  • Be aware of the potential for significant harm to patients.
  • Be aware of the changing fashion in CAM use
  • How to evaluate evidence of safety and efficacy.
  • Appropriate use in the NHS.

Systems: Specialities AB (19 decks)

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