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Microbiology > Clostridum > Flashcards

Clostridum Flashcards

(6 cards)

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1
Q

Species of medical importance clostridium

A 
Clostridium tetani
Botulinum 
Clostridium perfringens
Clostridium septicum
Clostridium difficile
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2
Q

Clostridium tetani

A

Large gram positive
Spore forming rods
Anaerobes
Produces tetanus toxin

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3
Q

Reservior

A

Soil

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4
Q

Transmission

A

Human bites

Requires low tissue oxygenation

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5
Q

Pathogenesis

A

Spores germinate in tissues
Producing tetanus toxin, exotoxins (tetanospasmin)
Carried intra-axonally to CNS
binds to ganglioside receptors
Blocks release of inhibitory mediators (glycine, GABA)
Excitatory neurons are unopposed …. extreme muscle spasm
Most toxic substances known

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6
Q

Disease: tetanus

A 
Risus sardonicus
Opistholonus
Extreme muscle spasms
Drooling
Hydrophobia
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Microbiology (7 decks)

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