Cluster of Differentiations Flashcards
What are CD’s
they are the main cell surface receptors
CD2 Function *LFA-2
adhesion molecule
CD3 Function
signal transduction by TCR
CD4 Function
Co receptor MHCII, HIV
CD8 Function
Co receptor MHC I
CD 14 Function *LPS Receptor
Binds LPS, epithelioid cells in the granulomatous lesions of leprosy are CD14 cells
CD16 (Fc Receptors) Function
Opsonization ADCC
CD18 Functions
Cell Adhesion Molecule
CD19 Functions
Co receptor with CD 21 for B cell, activation for signal transduction
CD20 Function
B cell activation
CD21 (CR2, C3d Receptor) Function
C3d receptor with CD19, Epstein-Barr virus receptor
CD25 Function
Alpha chain of IL-2 receptor
CD28 Function
T-cell receptor for costimulatory molecule B7
CD34 Function
Cells-cell adhesion, binds L-section
CD40 Function
Binds CD40L, role in T cells dependent B cell, macrophage, dendritic cell and endothelial cell activation
CD2 Cellular Expression
T cells, Thymocytes, NK cells
CD3 Cellular Expression
T cells, Thymocytes
CD4 Cellular Expression
TH Cells, Thymocytes, Monocytes/Macrophages
CD8 Cellular Expression
CTLs, some Thymocytes
CD14 Cellular Expression
Monocytes, Granulocytes
CD16 Cellular Expression
NK Cells, Macrophages, Neutrophils
CD18 Cellular Expression
Leukocytes
CD19 Cellular Expression
B cells
CD20 Cellular Expression
B cells
