Clusters of Differentiation

Question 1

CD20

Answer 1

predominantly B- cell marker expressed on B cells prior to differentiation into plasma cells, but in Ewing study, should not be used to differentiate B cell and T cell epitheliotropic lymphoma

Question 2

CD79

PAX5

Answer 2

Both CD79a and PAX5 are pan B-cell markers and have been used previously in dogs and humans to differentiate neoplastic lymphocyte populations…so if CD79 and PAX5 negative, there are no B cells there.

Question 3

Fc-alpha R

Answer 3

CD89; IgA receptor expressed on granulocytes, monocytes, some populations of T and B cells

Question 4

IL-6R

Answer 4

CD126; alpha chain of IL-6 expresed on B cells, plasma cells, epithelial cells, hepatocytes

Question 5

L-selectin

Answer 5

CD62L; selectins bind to carbohydrate structures (can be expressed on platelets, lymphocytes, endothelial cells)

Question 6

CD15s

Answer 6

Sialyl-lewis on neutrophils

Question 7

CD62E

Answer 7

e-selectin

Question 8

CD62P

Answer 8

P-selectin

Question 9

CD40

Answer 9

A member of TNF receptor superfamily. Binding to CD40L ligand on activated Th cells is essential for successful antibody response and class switching

Question 10

CD117

Answer 10

c-KIT

Question 11

CD54

Answer 11

ICAM-1; ligand for CD11a/CD18 and CD11b/CD18 integrins. especially expressed on endothelial cells

Question 12

CD83

Answer 12

member of immunoglobulin superfamily, used as a marker for mature dendritic cells. Unknown function

Question 13

CD25

Answer 13

part of IL-2 receptor

Question 14

CD__ is an interferon receptor

Answer 14

CD 118

Question 15

CD__ is TNF receptor

Answer 15

CD 120

Question 16

CD210

Answer 16

IL-10 receptor