Clusters of Differentiation (CD) Markers Flashcards Preview

1 Nexus Review USMLE > Clusters of Differentiation (CD) Markers > Flashcards

Flashcards in Clusters of Differentiation (CD) Markers Deck (20):
1

CD 2

- T cells & some NK,
- CD58 CD59 ligand,
- involved in ALL & T cell lymphoma

2

CD 3

- T cell receptor

3

CD 4

- T cell receptor for MHC Class II
- HIV receptor

4

CD 8

- T cell receptor for MHC Class I

5

CD 14

- Macrophage
- Receptor for LPS

6

CD 16

- NK cells

7

CD 19

- B cell

8

CD 20

- B Cell Calcium Channel
- B Cell Leukemia
- Hairy cell
- CLL
- Tx: Rituximab

9

CD 21

- B Cell
- EBV receptor

10

CD 26

- DPP4 (Dipeptidyl peptidase-4)
- Degrades GLP-1
- MOA - Gliptins,
- MERS-CoV receptor

11

CD 28

- T cells (ALL OF THEM)

12

CD 40

- On APC
- On Macrophage
- Binds CD140L (CD 154)
- CD 40L on T cell binds B cell CD 40 receptor causing resting B cell activation
- Deficiency causes Hyper IgM syndrome

13

CD 55

- Complement Decay-Accelerating Factor (DAF)
- inhibits MAC polymerization

14

CD 56

- NK cells (more specific than CD 16)

15

CD 59

- MAC-inhibitory protein (MAC-IP)
- Protectin
- Prevents C9 polymerization (MAC pore formation)

16

CD 95

- FAS receptor
- Apoptosis
- TNF receptor
- Activates/Releases Caspase & Cytochrome C

17

CD 120

- TNF receptor

18

CD 154

- CD 40 ligand (CD 140L)
- Stimulates class switching (B cells)

19

CD 195

- CCR5
- HIV receptor
- CCR5 Delta 32 mutation = HIV Resistance

20

CD 220

- Insulin receptor