CM: Intro to Male Repro Flashcards Preview

Block 8 - Endo & Repro > CM: Intro to Male Repro > Flashcards

Flashcards in CM: Intro to Male Repro Deck (25):
1

thick, fibrous plaques palpable deep w/i base of penile shaft
significant penile deformity during erection

Peyronie's dz

2

painless, firm masses of testicular parenchyma

testicular cancer

3

What is testicular torsion?

spermatic cord twists - testicle ischemic - surgery!

4

painful mass of gradual onset originating from outside testicle

epididymitis

5

soft homogenous scrotal mass that transilluminates

hydrocele

6

dilated and engorged testicular veins easily palpable in spermatic cord

varicocele (usually on left) - surgically correctable cause of male infertility

7

irregular contour, firmness, nodules on prostate exam

prostatic cancer

8

What is the role of FSH in spermatogenesis?

essential for initiation at puberty
stimulates normal levels in adult

9

What is the role of the seminiferous tubules during spermatogenesis?

lined by sertoli cells - tight jxns between divide into basal and adluminal compartments
blood testes barrier allows spermatogenesis to occur in immunologically privileged site

10

What are the roles of sertoli cells in spermatogenesis?

nurse cells
undifferentiated spermatogonia near BM
more advanced spermatids and spermatocytes near luminal surface

11

What is the order of differentiation of cells during spermatogenesis?

gonocytes --> spermatogonia --> spermatocytes (pre-meiotic) --> spermatids (post-meiotic) --> spermatozoa (mature)

12

What is the role of the epididymis in sperm production?

sperm transport and storage
sperm fertilizing ability (to penetrate zona pellucida)
motility maturation
transit about 12 days

13

What is the role of PSA?

to liquefy seminal coagulum

14

What is the normal physiology of an erection?

stimulus --> NO release --> cGMP formation --> vascular smooth muscle relaxation --> filling of sinuisoids w blood
PDE5 breaks down cGMP to reverse process

15

What are psychogenic causes of ED?

anxiety, loss of attraction, stress, relationship problems

16

What are psychiatric causes of ED?

depression

17

What are neurogenic causes of ED?

trauma, myelodysplasia, multiple sclerosis, DM, alcohol, pelvis surgery

18

What are endocrine causes of ED?

primary or secondary hypogonadism, hyperprolactinemia

19

What arteriogenic causes of ED?

HTN, smoking, diabetes, hypercholesterolinemia, peripheral vascular dz

20

What are venous causes of ED?

impairment of veno-occlusive mechanisms, peyronie's dz

21

What are drug induced causes of ED?

antihypertensives, antidepressants, hormones

22

What findings suggest psychogenic ED?

sudden onset, situational, normal nocturnal erections

23

What findings suggest organic ED?

gradual in onset, progressive, reduced nocturnal and early morning erections, normal libido and dev during puberty

24

What are the contraindications for PDE5 inhibitors?

pts taking nitrates
unstable angina or recent MI

25

What is priapism?

painful, unwanted, persistent erection which may produce ischemic damage to cavernous tissue if left untreated for >6hrs