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CML Flashcards

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1
Q

CML - What are the drugs used to treat CML?

A

imitinib, nilotinib, bosutinib, dasatinib, ponatinib, asciminib

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2
Q

CML - what is their clinical utility overall? MOA

A

Affect BCR-ABL1
t(9;22) translocate to form Philadelphia chromosome which increases proliferation of leukemic cells

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3
Q

CML - Which ones can we use for the T315i mutation?

A

ponatinib, asciminib

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4
Q

CML - which drug has less toxicity associated with its use?

A

asciminib

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5
Q

CML - what is the funny mnemonic?

A

indeed new boobs do pop ahhh

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6
Q

CML - true or false these are all tyrosine tyrosine kinase inhibitors

A

true

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7
Q

CML - what phase of CML growth is each drug good for

A

Imitinib - CP , AP, BP
Nilotinib - CP, AP,
Bosutinib - CP, AP, BP
Dasatinib - CP, AP, BP
Panotinib - CP, AP, BP
Asciminib - CP

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8
Q

What does CML stand for?

A

chronic myeloid leukemia

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9
Q

What drugs are indicated for MDS?

A

imatinib
Lenalidomide

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10
Q

what does MDS stand for?

A

myelodysplastic syndrome

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11
Q

MDS- mutation/ clinical utility of imatinib

A

FIP1A1/PDGFRA
- gene alternation of PDGFRA

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12
Q

MDS- mutation/ clinical utility of lenalidomide

A

deletion of 5q on chromosome 5 making it shorter

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13
Q

what does AML stand for?

A

Acute myeloid leukemia

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14
Q

AML- what are the drugs used to treat it?

A

Midostaurin
Gilteritinib
Ivosidenib
Enasidenib
Gemtuzumab

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15
Q

AML- what gene is affected?

A

FIC gene

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16
Q

AML- what is the mutation for midostaurin

A

FLT3

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17
Q

AML- what is the mutation for gilteritinib

A

FLT3

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18
Q

AML- what is the mutation for ivosidenib

A

IHD1

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19
Q

AML- what is the mutation for enasidenib

A

IHD2

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20
Q

AML- what is the mutation for gemtuzumab

A

CD33

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21
Q

AML- what are the mutations in FLT3

A
  1. exon 14 ITD (inframe)
  2. point mutation in the kinase loop domain
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22
Q

AML- what is the mnemonic used / how many drugs

A

my gosh ivan eats grapes

5

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23
Q

drugs for APL?

Study These Flashcards
A

arsenic trioxide and tretinoin

24
Q

What APL stands for?

Study These Flashcards
A

Acute promyelocytic leukemia

25
APL - mutaion/clinical utiliy
translocation of t(15;17) in PML/RARA genes
26
APL- affects what genes specifically
PML/RARA
27
CEL - what does it stand for
Chronic Eosinophilic leukemia
28
CEL - treatment
imatinib
29
CEL mutation/ clinical utility
FLIPA1A / PDGFRA - gene re-arrangement in PDGFRA
30
what does ASM stand for?
aggressive systemic mastocytosis
31
ASM - treatment
imatinib
32
ASM - caution point
not for the D816K mutation
33
ASM - clinical utility/mutation
C- KIT not for the D816V C-KIT mutation
34
ALL - what does it stand
acute lymphoblastic leukemia
35
ALL - What are the drugs?
Imatinib Dasatinib Ponatinib Blinatumomab Mercaptopurine Vincristine
36
ALL - what is the mnemonic
Icecream delicious pls bring me vanilla
37
ALL - what is the mutation or clinical utility of imatinib
BCR/ABL1 positive
38
ALL - what is the mutation or clinical utility of dasatinib
BCR/ABL1 positive
39
ALL - what is the mutation or clinical utility of ponatinib
BCR/ABL1 positive
40
ALL - what is the mutation or clinical utility of Blinatumomab
BCR/ABL1 negative
41
ALL - what is the mutation or clinical utility of vincristine
BCR/ABL1 negative
42
ALL - what is the mutation or clinical utility of mercaptopurine
TPMT/NUDT15 TPMT *2/*3A/*3C = reduce enzyme actvity NUDT *2/*3 = PMs NUDT *4/*5/*6 + IMs
43
ALL - indicated for resistance to treatment or intolerance to treatment or new
Dasatinib
44
ALL - indicated when no TKI other indicated
Ponatinib
45
ALL - which drugs can be used for t315i mutations?
ponatinib
46
CLL- drugs?
Ibrutinib and venetoclax
47
CLL- mutation and clinical utility
deletion of 17p
48
CLL- a drug with refractory of one prior treatment
venetoclax
49
ALL - what drugs should be given alongside chemotherapy
imatinib, dasatinib, ponatinib
50
what are the drugs for lymphomas?
rituximab Denileukin Deftitox Brentuximab Vedotin
51
lymphomas - which drugs are for non-Hodgkins diffuse B-cell lymphoma?
rituximab
52
lymphomas - which drugs are for Cutaneous T-cell lymphoma (CTCL)?
denileukin deftitox
53
lymphomas - which drugs are for peripheral T-cell lymphoma (PTCL)?
brentuximab vedotin
54
lymphomas - what is the clinical utility/mutation of rituximab?
CD20+
55
lymphomas - what is the clinical utility/mutation of denileukin deftitox?
CD25 component of IL-2 receptor
56
lymphomas - what is the clinical utility/mutation of brentuximab vedotin?
CD30

Gnemoics (6 decks)

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