CMV and EBV Flashcards Preview

PoD Test 3 > CMV and EBV > Flashcards

Flashcards in CMV and EBV Deck (19)
Loading flashcards...
1
Q

What are owl eye inclusions?

A

Large inclusions in the nucleus characteristic of CMV

2
Q

How does the genomic DNA compare to that of other herpesviruses?

A

It is larger

3
Q

What is unique about the CMV nucleic acid content?

A

Has viral mRNA in addition to double stranded DNA

4
Q

In a CMV infection, how long might it be before cytopathic effects take place?

A

4-6 weeks

5
Q

Where are latent CMV infections established?

A

Monocytes and certain bone marrow cells

Reactivated by immune suppression

6
Q

How are CMV progeny transmitted in the body?

A

Infected lymphocytes and leukocytes

Also infects vascular endothelial cells

7
Q

How can/what types of people can be infected by CMV?

A

Congenital infection

Perinatal infection

Normal children and adults

Transplant/Transfusion recipients

Immunocompromised individuals

8
Q

What type of infection is cytomegalic inclusion disease and what is targeted?

A

Congential infection - asymptomatic mother infects fetus in utero

Visceral organs are targeted

9
Q

What are the possible outcomes of a congenital infection?

A

Death -rare

Liver/spleen infection

Microcephaly

Thrombocytopenic purpura

Chorioretinitis

Low birth weight

Rash

10
Q

What is the most common virus caused congenital infection?

A

CMV

More common than rubella b/c of rubella vaccine

11
Q

How is CMV infection acquired in newborns?

A

Last trimester, CMV secreted in the cervix as a result of reactivation of latent infection

Newborn can also acquire infection from mother’s milk

12
Q

How do normal children and adults acquire CMV infections?

A

Saliva, urine, tears, blood can transmit virus

Sexual transmisstion

13
Q

What type of mononucleosis does CMV cause?

A

Heterophile antibody negative mononucleosis

14
Q

What risk is associated with CMV and transfusion or transplantation

A

Post-transfusion mononucleosis about 3-4 weeks after tanfusion with infected lymphocytes

CMV significant cause of failure of kidney transplants

15
Q

What can result in an unusual disease manifestation of CMV and what are the possible manifestations?

A

Reactivation of latent disease as a result of pregnancy, immunosuppression

Mononucleosis, pneumonitis, CMV retinitis, GI ulceration, colitis and esophagitis

16
Q

What are the initial stages of infection of CMV?

A

URI with regional lymph notdes

Early stages are silent ususally

17
Q

How does CMV spread from the initial URI infection?

A

Infected lymphocytes and monocytes spread the infection to secondary sites like the spleen/lymph nodes, salivary glands, kidney tubuels, cervix, testes/epididymis

18
Q

What occurs to T cells during CMV infection?

A

There is a temporary reduction in responsiveness

19
Q

What agents can cause congenital infections and defects (TORCH)?

A

Toxoplasmosis

Other - syphilis, listeria

Rubella

Cytomegalic inclusion disease

HSV