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Pharma2023 > Cns > Flashcards

Cns Flashcards

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1
Q

Examples of H2 receptor antagonist

A

Cimetidine

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2
Q

Which of the following antipsychotics at the lowest risk of diabetes?

A

Haloperidol

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3
Q

What treatment do use to mild to moderate Alzheimer’s disease?

A

Donepezil galantamine or rivastigmine

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4
Q

What is the treatment for Madre Alzheimer’s disease?

A

Memantine is the drug of choice in patients with severe Alzheimer’s disease

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5
Q

Parkinson disease, dementia treatment

A

ACH inhibitors donepezil and galantMine
Rivastigmine was the only treatment with the UK marketing authorisation donepezil, galantmine and rivastigmine mean patches off level

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6
Q

When would you consider memantine in Parkinson’s disease dementia

A

When cholineterase are not tolerated

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7
Q

Management of drooling, saliva in people with Parkinson’s disease

A

Glycopyrronium

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8
Q

Entacopone can you clear your urine what colour?

A

Red brown

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9
Q

Can pizotefin cause weight
Increase

A

Yes

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10
Q

Tamoxifen and fluoxetine

A

Fluoxetine is predicted to decrease the efficacy of Tamoxifen. Avoid severe.

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11
Q

Which anti-sickness medication is most appropriate to treat post-operative, nausea and vomiting for Parkinson patient

A

Cyclizine

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12
Q

Pizotifen idnicated

A

, prophylaxis of migraine

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13
Q

Which medicine is licensed as a twice daily dose by mouth for moderate dementia associated with Parkinson disease 

A

Rivastigmine is the only licensed ACH inhibitor used for moderate dementia associated with Parkinson disease. The other ACH inhibitors are unlicensed.

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14
Q

What is interaction between propanolol and amirodone

A

Amirodone is predicted to increase the risk of cardiovascular side-effects, when given with propanolol

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15
Q

Interaction between methadone and fludrocortisone

A

Severe interaction fludrocortisone and methadone is predicted to increase the risk of tosade de points

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16
Q

Focal seizures treatment

A

Carbamazepine and Lamotrigine

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17
Q

Find it on in plasma concentration range

A

Neonate to 3 months, 6 to 15 mg/L, (25-60 micromol/litre) chilc three months to 18 years 10-20mg/L

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18
Q

Lithium and venlaxfine

A

Risk of serotonin syndrome

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19
Q

Examples of dopamine receptor agonist

A

Apomorphine bromcriptine cabergoline

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20
Q

What is dementia?

A

Cause when the brain is damaged by diseases, such as Alzheimer’s drugs or Parkinson

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21
Q

Name 3 Ach inhibitors

Study These Flashcards
A

Donepezil -nms
Galantamine -sjs-
Rivastigmine- can chase GI disturbance

22
Q

Cholingeric side effects

Study These Flashcards
A

Diarrhoea, urination, muscle, weakness, bronchospasm, bradycardia, vomiting, teary, eyes, salvation

23
Q

When do you use antipsychotics and dementia?

Study These Flashcards
A

When it is severe risk of increased risk of stroke and death

24
Q

Tonic clonic seizures

Study These Flashcards
A

Sodium valproate Lomtragine carbamazepine

25
Absence seizures
Ethosuximide or valproate
26
Myoclonic a tonic clonic
Valproate
27
When can you drive a car in epilepsy
Seizure free for one year established pattern were no influence or unconsciousness. No history of unprovoked, seizures, seizures, due to change or withdrawal.
28
Policy for seizure while asleep
Can drive if history of history of no wake seizures from one year from 1st to sleep, seizure establish pattern of sleep stages for three years of previous awake seizure
29
Which drugs do you monitor foetal growth?
Topirmate / levetiracetam
30
What is vigabatrin Associated with
Encephalopathic symptoms mark sedation confusion
31
Why is it important to remember about for phenytoin monitoring plasma
Small changes in dose missed doses change in drug absorption nonlinear relationship between dose on concentration. Phenytoin is highly protein bound drug when the protein binding is reduce monitor the plasma free concentration
32
What can carbamazepine exacerbate
Atonic clonic and myoclonic seizures
33
What do pharmacist I need to do every time you dispense valproate?
Patient card remind risk of pregnancy remind of need for annual specialist review dispense asshole packs whenever possible patient guide
34
Name, the two short acting benzodiazepine
Lorazepam oxazepam
35
How long does busiprone take to work
2 weeks
36
How to withdraw benzodiazepines
Gradually convert over one week to equivalent diazepam dose, reduce diazepam dose by wanted to MG increments every 2 to 4 weeks
37
Atomextine side effect
Suicidal ideation, liver toxicity, QT prolongation
38
What is a contra indication in bipolar disease?
Do not give antidepressants in rapid cycling bipolar disorder. Recent history of hypo mania, manic episode.
39
When would you think an antidepressant is it in effective?
Wait, four weeks, six weeks in the elderly
40
How long to continue antidepressants
Continue for at least six months 12 months in the elderly 12 months in generalised anxiety disorder, two years in recurrent depression
41
How to switch between antidepressants
Wait two weeks before - MAOI (moobemide does not require washout period ) switching with one week before -SSRI (5 weeks for fluxteine 2 weeks if sertaline switching with one to 2 weeks before switching - TCA -3 weeks if imipramine or clomipramine
42
Which drugs has the highest risk of withdrawal reaction?
Paroxetine and venlafaxine
43
Interaction between trancypromine clomipramine with pseudoephedrine adrenaline noradrenaline
Hypertensive crisis
44
Patient counselling for Moa
Avoid food containing tyramine mature cheese, wine eat only Fresh Food, the dangers of food and drug interactions exist two weeks after stopping 
45
Four: the pain, when would you assess effectiveness?
Try for at least 8 to 10 weeks, if two or more doses are missed then re- assistant reinitiate by specialist
46
What anti-sickness is used in palliative care
Haloperidol, levomeppromazine
47
Anti-sickness in chemotherapy or post operative, nausea and vomiting
Granistron ondasteron palonosetron
48
Anti emetic prevention
Driperidol dexamethasone phenothiazine
49
5HT receptor antagonist interaction
Increased risk of torsade de pointes with hypokalemia - loop diuretics, corticosteroids Increased risk of QT prolongnation - amirodaone claithrymycin quinine sumatriptan lithium Serotonin syndrome - 5ht1 agonist - moa ssri
50
Breakthrough dose
1-10 or 1/6th of the total daily dose

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