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FRCR 2B > CNS > Flashcards

CNS Flashcards

1
Q

Key differences of lymphoma vs toxoplasmosis?

A

Lymphoma -
Solitary lesion
Subependymal spread/corpus callosum
Restricts DWI
Hyperdense on CT
HOT Thallium SPECT

Toxoplasmosis -
Multiple lesions.
Significant oedema - target sign
Basal ganglia
No restriction DWI
COLD Thallium SPECT

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2
Q

Paediatric brain tumour with asymtetical ventricular dilatation?

A

Choroid plexus papilloma

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3
Q

Large, mixed solid/cystic mass in child < 2 years of age with increasing head circumference and bulging Fontelle’s ?

A

Desmoplastic infantile ganglioglioma/Astrocytoma (DIG)

Is always SUPRTENTORIAL

Good prognosis vs the INFRATENTORIAL Atypical teratoma/rhabdoid

Giant hemispheric tumor of superficial cortex & leptomeninges, often attached to dura
Large, mixed solid/cystic mass in child < 2 years of age
Cortically based, enhancing solid nodule/plaque, adjacent pia + reactive dural thickening

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4
Q

Imaging features of Dandy-walker malformation?

A

Cystic dilatation of the 4th ventricle

Enlarged posterior fossa with elevated tentorium - ‘Torcular-lamboid inversion’

Cerebellar vermis agenesis - superior rotated vermain remnant

Small and widely spaced cerebellar hemispheres

Hydrocephalous

addition-
dysgenesis or agenesis of the corpus callosum
occipital encephalocele
polymicrogyria and grey matter heterotopia

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5
Q

What defines persistent Blacke pouch?

A

Cyst posterior and inferior to the vermis, that communicates with the 4th ventricle but not the cisterna magna

Structurally normal vermis that is rotated

Posterior fossa is not expanded

Tentorium is elevated

Mega cisterna magna =

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6
Q

Increases T2 signal in bilateral medial thalamus and periaqueductal gray and enhancement of the mammillary bodies?

A

Wernicke

WW1

Remember wernickes is Thiamine deficency - T for thalmus

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7
Q

T2 bright globus pallidus?

A

Carbon monoxide poisoning

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8
Q

Swelling and T2 bright corpus callosum in alcoholic ?

A

Marchiafava-Bignami

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9
Q

Optic nerve atrophy, haemorrhagic putaminal and subcortical white matter necrosis?

A

Methanol poisoning

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10
Q

Appearances of acute hepatic encephalopathy?

A

AHE: Bilateral swollen T2-/FLAIR-hyperintense gyri (most severe insular cortex, cingulate gyri) with diffusion restriction

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11
Q

Appearances of chronic hepatic encephalopathy?

A

CHE: Bilateral T1WI hyperintensity in basal ganglia (BG), particularly globus pallidus (GP)

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12
Q

Neonatal CNS infection with periventricular calcifications and polymicrogyria?

A

CMV

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13
Q

Neonatal CNS infection with basal ganglia calcifications and hydrocephalus ?

A

Toxoplasmosis

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14
Q

Neonatal CNS infection with Haemorrhagic infarcts resulting in encephalomalacia and atrophy?

A

HSV

nb - 90% HSV-2

Unlike HSV-1 in adults doesnt involve limbic system

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15
Q

Neonatal CNS infection with predominant frontal lobe atrophy?

A

HIV

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16
Q

Key difference between HIV encephalitis and progressive multifocal leukoencepalopathy?

A

HIV = Symmetric T2 hyperintensities deep WM that spare the subcortical U fibres. T1 signal is normal

PML - Asymmetric scattered T1 hypointensities and T2 hyperintensities out of proportion to mass effect. U fibres involved.

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17
Q

HIV with brain atrophy, periventricular hypodensities and ependymal enhancement?

A

CMV

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18
Q

Imaging patterns of Cryptococcus

A

-Cryptococcomas are typically non-enhancing low density lesions in the basal ganglia/dilated perivascular (Virchow-Robin) spaces filled with fungi, mucoid material.

Differentiated from VR spaces on FLAIR - VR spaces will suppress (being CSF in content)

-Leptomeningeal enhancement - Basilar meningitis

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19
Q

Features of HSV encephalitis in adult?

A

-Swollen medial temporal lobe and T2 hyperintense
- ***Diffusion restriction is the earliest sign
- Spares basal ganglia (distinguish from MCA stroke)

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20
Q

High T2/FLAIR on the dorsal medial thalamus, caudate lobe and putamina bilaterally with diffusion restriction?

A

CJD

Nb - called ‘ hockey stick’ sign

Also look for cortical gyriform restriction

WW3

C = caudate nuclei

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21
Q

4 stages of Neurocysticercosis (VCGN) ?

A

Vesicular -
Thin walled cyst - CSF pattern. No pericystic oedema. (Low T1/T2)
scolex (hole with dot appearance)

Colloidal -
Hyperdense cyst - proteinaceous fluid) (High T1/T2) . **pericystic oedema and enhancement **
scolex (hole with dot appearance) can persist

Granular -
Cyst shrinks, small ring-enhancing or solid nodule enhancement. less pericysitc oedema

Nodular -
Small calcified lesion. no oedema or enhancement. hypointense on all sequences due to calcification

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22
Q

Signs of extra-axial location ?

A

CSF Cleft
Displaced subarachnoid vessels
Displaced and expanded subarachnoid spaces
Cortical gray matter between the mass and white matter
Borad dural base/tail
Bony reaction

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23
Q

MRCT is mnemonic for haemorrhagic/hyperdense brain Mets?

A

Melanoma
Renal Cell
Carcinoid/Choriocarcinoma
Thyroid

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24
Q

Cortically based tumours ( P- DOG) ?

A

Pleomorphic Xanthoastrocytoma (PXA)
Dysembryoblastic neuroepithelial tumour (DNET)
Oligodendroglioma
Ganglioglioma

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25
Q

Adult (40-50s) temporal lobe mass cortical mass ± adjacent enhancing leptomeninges . Often cystic with enhancing mural nodule

A

PXA

Peripheral based cortical tumour that abuts the meninges and history of seizures!!

**Can have Dural tail sign **

Cystic and mural enhancing nodule

Can be very similar to ganglioglioma

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26
Q

Adult (40-50s) frontal lobe mass with calcificaiton, that expands the cortex?

A

Oligodendroglioma

CALCIFICATION

1p/19Q deletion = Great prognosis

Can enhance. Calcification is Key!!

Temporal lobe too!!

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27
Q

Teenager with seizures, Temporal lobe mass that is cystic and solid with focal calcifications?

A

Ganglioglioma

MURAL nodule typical

WELL-CIRCUMSRIBED.

It is low grade but can enhance. Can look lie ANY cancer.

Commonest cause for temporal epilepsy

28
Q

Teenager with drug resistant epilepsy, temporal lobe lesion. High T2 signal ‘bubbly lesion’ ?

A

DNET

MULTICYSTIC

Doesn’t enhanced and little if any surrounding oedema

FLAIR the lesions show a hyperintense ring

29
Q

Tumours that ordinate from the ventricular wall?

A

Ependymoma
Medulloblastoma
Subependymal giant cell astrocytoma - (SEGA)
Subependymoma
Central neurocytoma

Nb Meningioma can be intraventricular

30
Q

Medulloblastoma and Ependymoma are causes of posterior fossa paediatric tumours, what are the key differences?

A

Medulloblastoma
-Most common infratentorial paediatric tumour
-Originate cerebellar vermis/roof of 4th ventricle
-Do not extend in the basal cisterns
-Drop met - ‘Zuckerguss’
- **Homogenous enhancement **
- Ca2+ (10%)

Ependymoma
-Less common
-Originate floor of 4th ventricle
- Extend into the basal cisterns ‘tooth paste’ through foramen luschka and magendie
-Calcify more (50 %)
- Heterogenous enhancement

31
Q

Child with seizures, mental retardation, AMLs. What is the paediatric intraventricular lesion?

A

Subependymal giant cell astrocytoma - (SEGA)

Arises from the lateral wall of the ventricle near foramen of monro, and often causes hydrocephalus

Linked with TS - Differentiated Subependymal Nodules (SEN) - stay stable in size and occur anywhere along the ventricle

32
Q

Two adult intraventricular tumours and their key differences?

A

Subependymoma
-Well circumscribed at inferior 4th ventricle typical (60%)
Other locations: Lateral > 3rd ventricle > spinal cord
-Dont enhance, Benign
-Typically asymptomatic but can cause hydrocephalus

Central neurocytoma
- Most common IV mass in adult = **Lateral ventricle attached to the septum pellucidum **
- ‘Swiss cheese’ **‘bubbly’ **appearances - numerous cystic spaces on T2
- Calcify

33
Q

Origin of Choroid plexus papilloma in Children and adults ?

A

Children = TRIGONE of the later ventricle.
Adults = 4th Ventricle

Much more common type of tumour in children.
**Present lobulated (cauliflower) enhancing mass in lateral ventricle with hydrocephalus.

Cant differentiate radiologically between choroid plexus carcinomas.
10:1 CPP vs CPC

34
Q

Despite CPP and CPA name another choroid plexus tumour?

A

Xanthogranuloma

Benign although restricts diffusion. Usually, bilateral.

35
Q

Hyperdense round well circumscribed lesion in the anterior 3rd ventricle?

A

Colloid cyst

Although benign can cause death via sudden acute hydrocephalus.

If contain cholesterol with be T1 and T2 bright

36
Q

Differential for CPA lesions?

A

Vestibular schwannomna (75%)
Meningioma (10%)
Epidermoid (5%)
Dermoid cyst
IAC lipoma
Arachnoid cyst

37
Q

Key differences between vestibular schwannoma and meningioma ?

A

Vestibular schwannoma
-Invade the IAC
-IAC can have ‘trumpet’ apperance

Meningioma
-Homogenous enhancement
-Dont usually invade the IAC
-often calcifiy

38
Q

Distinguish between epidermoid and arachnoid cyst?

A

Epidermoid are bright on FLAIR and will restrict diffusion.

Arachnoid follows CSF so is dark on FLAIR and doesn’t restrict

Epidermoid can be congenital or acquired (after trauma)

39
Q

Epidermoid vs dermoid?

A

Dermoid behaves like fat bright on T1 and hypodense on CT
Dermoid is more central and epidermoid off midline
Dermoid can rupture

40
Q

Posterior fossa tumour in child which is cystic and enhancing nodule?

A

Juvenile pilocytic astrocytoma

**Commonly from vermis **

very similar to hemangioblastoma but PCA more likely to be larger than 5 cm, contain calcification, have a larger mural nodule, are thick-walled

In adult
Hemangioblastoma

**Floor of the 4th ventricle
**
Associated with VHL, esp if multiple.

Vs PCA
Hemangioblastoma show angiographic contrast blush to the mural nodule and associated with erythrocythaemia

41
Q

Key difference between skull base chordoma and chondrosarcoma?

A

Chordoma
-Locally aggressive MIDLINE clivus
-Most commonly located in the pelvis
-thumbprinting of the pons

Chondrosarcoma
- LATERAL to midline
-‘Rings and arcs’ matrix
-Also favours the TMJ
- cranial nerve palsy- abducens (CN VI) nerve is most often affected and CN III, V, VII and VIII may also be involved

42
Q

Dural lesion that mimics an aggressive meningioma?

A

Haemangiopericytoma

Soft tissue sarcoma.

Like meningioma but no calcification and will invade the skull.

43
Q

Two types of craniopharyngioma in suprasellar/sellar ?

A

Papillary
- Adults (Papi)
- Solid and less Ca2+

Adamantinomatous
-Children
-**Calcified **
-Can recur

44
Q

Features of Hypothalamus Haemartoma?

A

In between the optic chiasm and the mamillary bodies - Tuber cinereum

Occur in children and T1 and T2 low and do not enhance.

Gelastic seizures

45
Q

Pineal mass in young boy with precocious puberty, heterogenous in T1 and T2?

A

Germinoma

Engulfed Caclification

Heterogenous as mixed fat and Ca2+

Secretes hcg = precocious puberty

46
Q

Childhood highly invasive pineal mass, hetergennous and avidly enhancing?

A

Pineoblastoma

Exploding popcorn calcification

Associated with retinoblastoma

Nb Popcorm calcification also in the rare pineocytoma - non-invasive well circumscribed

47
Q

Fracture through lateral nasal aperture ?

A

Le Fort 1

Palate is separated from the maxilla = Floating palate

Pyriform rim + medial & lateral walls of maxillary sinus or alveolus + nasal septum

48
Q

Fracture of inferior orbital rim and orbital floor ?

A

Le Fort 2

Maxilla separated from the face = Pyramidal

Medial orbital wall, inferior orbital wall + inferior rim

49
Q

Fracuture of Medial orbital wall, lateral orbital wall, including zygomaticofrontal suture + zygomatic arch

A

Le fort 3

Craniofacial dissociation

50
Q

Vascular malformation causing pulsatile tinnitus?

A

Dural AVF

Acquired secondary to dural venous sinus thrombosis (sigmoid sinus = pulsatile tinnitus).
Visual symptoms if cavernous sinus is involved.

No nidus

DDx for pulsatile tinnitus
Persistent stapedial artery

51
Q

Low flow vascular malformation without intervening normal brain tissue ?

A

Cavernous malformation

Popcorn ball appearance with complete peripheral hypointense hemosiderin rim on T2 MR

gradient echo.

Nb - Normal intervening brain tissue that developed compilation from radiation therapy = Capillary telangiectasia

52
Q

What is crescent sign ?

A

Vascular dissection

T1 bright intramural blood surrounding the lumen on Axial T1WI FS

53
Q

40 year old with migrane headaches, diffuse WM Disease and dementia?

A

CADASIL

Cerebral autosomal dominant arteriopathy and subcortical infarcts and leukoencephalopathy

54
Q

Appearances of the ventricles in corpus callosum agenesis?

A

-Colpocephaly = Dilatation of the occipital horns of the lateral ventricles
- ‘Vertical ventricles ‘ lateral ventricles widely spaced
-‘Steer horn’ - shape of anterior horns of the lateral ventricles on coronal

DDX with Lobar holoprosencephaly - Absent CSP too

Nb Callosal agenesis/dysgenesis is associated with pericallosal lipoma. Found typically in the interhemispheric fiisure

55
Q

Enlargement of all parts of cerebral hemisphere with large ventricle ?

A

Hemimegalencephaly

The grey matter is disorganised and thickened, consistent with migration arrest
expanded cranial vault

Nb other malformations from arrested migration of neurones

Band heterotopia = form grey matter layer within the centrum semiovale or subcortical white matter.

**Lissencephaly **(smooth brain) is a severe malformation of the cerebral cortex that results .
absence or a paucity of gyri (agyria or pachygyria, respectively). Hx multiple seizures and hypotonia all limbs

56
Q

Define Chiari 1 malformation?

A

One cerebellar tonsil more than 5mm below the foramen of magnum

Look for Syrinx (50%)

57
Q

Features of Chiari 2 malformation?

A

= **Small posterior fossa with cerebellar compression and hindbrain herniation through foramen magnum
**
-cerebellar herniation
-4th ventricle compression = hydrocephalus
-obliteration of the cisterna magna
-lumbar myelomengiocele

Other findings include
callosal dysgenesis
tectal beaking
enlarged massa intermedia
cervical medullary spUR

Foetal US
-Banana sign if cerebellum wraps around midbrain
-Frontal bone concavity (lemon sign)

CT and MRI
-colpocephaly (enlarged occipital horn and atria)
‘batwing’ configuration of frontal horns on coronal view (pointing inferiorly secondary to enlarged caudate nucleus),
-‘hourglass ventricle’
- excessive cortical gyration (stenogyria)

58
Q

Featutes of Chiari 3?

A

Chiari 2 + Encephalocele (either high cervical or low occipital)

59
Q

Non enhancing, noncalcified, small suprasellar cyst with intracystic nodule which is hyper bright on T2. kidney shaped on axial.

A

Rathe cleft cyst

Can be homogenously high on T1WI (depending on protein content)

“claw” of enhancing pituitary gland wrapped around cyst

between the anterior and posterior pituitary

60
Q

2cm Pituitary lesion that displaces the ICA. T1 Low and T2 bright. No calcification

A

Pituitary adenoma

most common seller lesion. Figure 8

Can have cyst and haemorrhagic components

> 1cm macro < 1cm micro

Can’t distinguish the mass from pituitary. if you can = MENINGIOMA.

61
Q

Partially Ca⁺⁺ mixed solid/cystic suprasellar mass in child with avid enhancement?

A

Craniopharyngioma

Children - adamantinomatous type -

Small intrasellar component and fluid-fluid level.

Craniopharyngiomas are the 90% tumors (90% cystic, 90% Ca⁺⁺, and 90% enhancing).
Mass effect can cause DI or growth retardation due to compression of the hypothalamus.

DDX
Thickened infundibulum, absence of normal posterior bright T1, and DI = LCH or germinoma

Papillary = adults.
Solid, less ca2+

62
Q

Appearances of acute hepatic encephalopathy?

A

Bilateral swollen T2-/FLAIR-hyperintense gyri (most severe insular cortex, cingulate gyri) with diffusion restriction

Remember in Chronic
Bilateral T1 hyperintensity in globus pallidus (GP)

63
Q

CNS features of tuberous sclerosis

A

Cerebral tubers
Cortical/subcortical lesion expanding overlying gyri
T2/FLAIR hyperintense, T1 hypointense after myelination
T1 hyperintense prior to myelination

Cerebellar tubers
Wedge-shaped foci of volume loss
Often enhance & calcify

Subependymal nodules (SENs)
Elongated nodules in locations of fetal germinal matrix
↑ Ca⁺⁺ over time
30-80% enhance

Subependymal giant cell astrocytoma (SEGA)
Growing nodule at caudothalamic groove
WHO grade 1 neoplasm

64
Q

Blood on MRI

A

Hyperacute (hours) - T1 iso, T2 bright

Acute (0-2 days) Intracellular deoxyHb - T1 iso T2 dark

Early subacute (3-7 days) Intracellular metHb - T1 bright, T2 dark

Late subacute (8-30 days) Extracellular metHb - T1 and T2 bright

Chronic (> 30 days) Intracellular haemosiderin - T1 and T2 dark (dark rim)

65
Q

Cavum Velum interpositium, Cavum vergae, Cavum septum pellucidum

A

Cavum Velum interpositium
-Triangular-shaped CSF space
-Between lateral ventricles, over thalami
-Apex points toward but does not extend anteriorly beyond foramen of Monro
-Base contiguous with quadrigeminal cistern

Cavum vergae
-Elongated finger-shaped CSF collection between lateral ventricles
- continuation from cavum septum pellucidum

Cavum septum pellucidum
-normal finding in all preterm infants
-known as the 5th ventricle.
-triangular shaped CSF space in between the anterior horns of the lateral ventricles.

66
Q

Key difference between Epidural and subdural haematomas?

A

Epidural - cross midline but not sutures

Subdural - DONT cross midline but can cross sutures and dip into the flax cerebri

67
Q

Features of MS

A

Optic neuritis (infraorbital portion)
Signal changes Corpus callosum, periventricular, middle cerebellar peduncle

FRCR 2B (8 decks)

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