CNS Injury Flashcards
(36 cards)
Define concussion, or mild traumatic brain injury
An alteration in mental status, disturbance of equilibrium, etc. caused by biomechanical forces that may or may not cause loss of consciousness. The hallmarks of concussion are confusion and amnesia.
List the symptoms of concussion.
The most common symptoms of concussion include headache, dizziness, poor attention, inability to concentrate, memory problems, fatigue, irritability, depressed mood, intolerance of bright lights or loud noises, and sleep disturbances.
What are the peak age groups and mechanisms of concussions?
Peak age group: 24-35 years old. Most common mechanisms: Motor vehicle accident, Recreation, Violence, Falls, Bicycles, Shaken baby syndrome, motor vehicle violence.
What are examples of contact phenomena and what injuries commonly result?
Contact phenomena includes strikes from bats, clubs, pool cues, rocks, etc. Injuries include Scalp lacerations, subgaleal hematoma, skull fractures, epidural hematomas.
What is a cerebral contusion and what conditions may result from one?
A contusion is a brain bruise. Contusions may cause swelling, brain shift, increased intracranial pressure, and herniation, resulting in secondary brain injury. Low mortality rates.
What are the two types of acceleration injuries?
Translational (straight line motion) and Rotational (pivot around a point).
What injuries may result from a translational acceleration injury?
A translational injury may result in stretching/tearing of veins between the brain and dura (causing subdural hematomas), contusions, and coup-contracoup injuries. When combined, these have a high mortality rate.
What injuries may result from a rotational acceleration injury?
A rotational injury may result in microscopic tearing of nerve cells in the brain (diffuse axonal injury). No recognizable injury without a microscope. Presentation may be anything from concussion to life-long coma. White matter in brain stem, corpus callosum, and cerebral hemispheres (esp. at white matter-grey matter junctions) is most affected. Possible small bleeds in corpus callosum on MRI/CT.
What injuries may result from a penetrating injury?
Penetrating injuries may have direct damage or damage due to pressure/fluid waves from high velocity projectiles in GSW.
Name two types of secondary brain injuries
Hypoxia, hypotension
What are five types of skull fractures?
Linear, depressed, basilar, diastatic, growing
What does a linear or diastatic skull fracture indicate?
High velocity impact. Seen on radiological imagining. No independent importance, but suggested need for close examination of underlying brain structures via MRI/CT. Diastatic occur along skull suture lines, same significance.
What does a basilar skull fracture indicate?
Common with high-velocity, blunt injuries. May extend through the cribriform plate or petrous bone and result in CSF leaks (otorrhea/rhinorrhea), leading to risk of meningitis.
What does a depressed skull fracture indicate?
Depressed skull fractures may force bone fragments into skull interior or the brain itself. Surgical intervention may be required to remove fragments or correct cosmetic defects.
What does a growing fracture indicate?
Growing fractures occur during the first 18 months of infancy. The arachnoid herniates through the fracture line and pulsing CSF motion causes progressive bone loss.
What is a diffuse axonal injury?
DAI results from high velocity rotational acceleration injury. Shearing of axons, causes “retraction balls” on microscopic exam, typically at white/grey matter junctions due to difference in density. No sign on CT, MRI = tiny bleeds in CC or white matter tracts.
What is the process that leads to secondary injury in the brain?
The primary injury occurs at impact, directly damaging neurons, and is largely irreversible. Secondary injury results from inadequate resuscitation, leading to hypoxia, altered blood flow, and release of free radical mediators. Free radical mediators break down the BBB, leading to interstitial/vasogenic edema. Swelling, inc ICP, further hypoxia, dysautoregulation, and herniation result.
What is the goal of treatment of head injuries?
Many head injuries cause hypoxia, altered blood flow, and release of free radical mediators which then cause an increase in ICP which leads to reduced perfusion of the brain, causing greater hypoxia in a positive feedback loop. Treatment is focused on breaking this loop.
What are the signs and symptoms of increased Intracranial Pressure?
Frequently manifest as abrupt changes in neurological condition, including headache, nausea, vomiting, then progressive lethargy and eventual loss of consciousness.
What are four herniation syndromes?
Subfalcine, Central, Uncal, Tonsillar
What occurs in a subfalcine herniation?
A subfalcine herniation occurs when the cingulate gyrus herniates under the falx cerebri. The anterior cerebral artery is often kinked and may result in a stroke in its distribution.
What occurs in an Uncal (Transtentorial) herniation?
And Uncal herniation occurs when the uncus herniates across the tentorial edge and down into the posterior fossa. It compresses the midbrain and ipsilateral cerebral peduncle. Results in third nerve palsy (test pupillary light reaction) and contralateral hemiparesis or hemiplagia. May also cause Duret hemorrhage in brainstem, disrupting the ascending reticular activating system.
What occurs in a central herniation?
Central herniations occur when there is a downward pressure centrally and can result in bilateral uncle herniation. Results in loss of consciousness.
What occurs in a Tonsillar herniation?
The cerebellar tonsils herniate down into the foramen magnum (“coning”). The medulla is compressed, may produce abnormal cardiac and respiratory responses, including Cushing’s reflex (Bradycardia, Hypertension, high ICP). Assoc’d with mass lesions in posterior fossa.
