CNS Neurotransmission Flashcards Preview

Toxicology and Pharmacology > CNS Neurotransmission > Flashcards

Flashcards in CNS Neurotransmission Deck (15):
1

What are the types of cells in the brain?

Neurons
Astrocytes
Microglia
Endothelial cells
Pericytes
(scare t cells)
Fibroblast like cells

2

What are the parts of a neuron?

Nucleus
Soma (cell body)
Dendrites
Axon

3

What is a neurotransmission?

Neurotransmitter release from the presynaptic cleft, crosses synaptic cleft, acts on post synaptic receptors, propogates an AP

4

What does neurotransmitter acting on post synaptic receptors usually do?

Excite or inhibit a response using,
Ligand gated ion channels
GPCR - secondary messangers

5

How is neurotransmission terminated?

Metabolism
Transportation (re-uptake by neurons, astrocytes by specific transporters)

6

Where do drugs act on the brain?

Enzymes
Ion channels
Neurotransmitter transporters
Neurotransmitter Receptors
Transducer Proteins

7

What do must drugs in the brain commonly interact with?

Most drugs that act on the CNS do so by interacting in some way with chemical neurotransmission

8

What are the types of neurotransmitters and examples?

-Monoamines - 5HT, NE
-Aminoacids - GABA, Glutamate
-ACh
- Neuropeptides - cotransmitters

9

What do neuromodulators do?

Produce slower responses

10

What do neurotrophic factors do?

Work over long time-scales. Promote neuronal survival and synaptic plasticity

11

What is the difference between fast acting and slow acting neurotransmitters?

fast acting, act on ion channels e.g Glutamte, GABA
Slow acting, act via GPCRs, e.g Dopamine, neuropeptides

12

What is the function of astrocytes?

Inflammatory role
BBB maintenance
Maintain CNS health / neuronal health

Release and take up neurotransmitters
Express neurotransmitter receptors
Regulates synaptic transmission

13

What is gliotransmission?

Release of neurotransmitter from astrocytes that acts on neurons\

Might mean astrocytes provide complex brain function

14

What do microglia do?

immune role
monitors brains microenvironments

15

What is the function of pericytes?

Encase endothelial cells and help maintain BBB