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Hugh's MD2 Pathology > CNS Pathology > Flashcards

Flashcards in CNS Pathology Deck (13)
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1
Q

What is a Pittsburgh B scan for?

A

Lights up amyloid protein in investigation of AD

2
Q

What are MRI finding in brain atropy?

A

Enlarged ventricles

Reduced size of gyri

Increased relative size of sulci

3
Q

What is amyloid?

A

Insoluble protein deposited in extracellular space that has a tightly folded beta-pleated structure

4
Q

What stains are specific for amyloid?

A

Congo red (formalin)

Thioflavin T stains (frozen sections)

5
Q

What are some histopath feature of GBM?

A

Hypercellularity with mitoses

Nuclear processes

No defined cellular membrane

Endothelial cell hyperplasia

6
Q

What does the presence of a IDH-1 mutation in a GBM predict?

A

Better response to chemotherapy - temozolamide

7
Q

How do meningomas appear histopathologically?

A

Whirl bodies

8
Q

How do pituitary adenoma present?

A

Headache

Visual changes

Acromegaly

Cushing’s

Hyperprolactinaemia

9
Q

Which

A

Lung

Breast

Melanoma

Renal cell cancer

Colonic

10
Q

When are brain abscess seen?

A

First 4 decades of life

11
Q

What is the etiology of brain abscesses?

A

Direct extension

Haematological spread

Trauma

Unknown

12
Q

What are the major pathiological findings in PD?

A

Loss of pigmentation in the substantia nigra

Lewy bodies and lewy neurites

13
Q

What is primary angiitis?

A

Rare disorder of CNS

Vasculitis of the CNS only