CNS Tumors and Neuropsych Symptoms - Rothrock

Question 1

what is the most common met to the brain?

Answer 1

lung

Question 2

What are the most common mets to the brain in order?

Answer 2

lung
breast
melanoma
GI/GU

Question 3

GI/GU mets are typically (single/multiple)

Answer 3

single

Question 4

lung, melanoma and tumors of unknown origin typically have (single/mutliple) mets

Answer 4

mutliple

Question 5

Which two lobes are most commonly involved in mets?

Answer 5

frontal and parietal

Question 6

What are the two types of cranial nerve tumors?

Answer 6

Acoustic neuroma aka schwannoma

optic nerve glioma

Question 7

What is the hallmark of extradural mets to the spinal cord?

Answer 7

PAIN

Question 8

What type of primary tumors for intradurally/extramedullary in the spinal cord?

Answer 8

meningiomas

Question 9

What type of primary tumors form intramedullary in the spinal cord?

Answer 9

astrocytoma and ependyomas

Question 10

T/F: there is such a thing as cancerous meningitis

Answer 10

true: carcinomatous meningitis

Question 11

Subacute infectious meningitis is also known as…

Answer 11

tuberculous meningitis

Question 12

What are the common causes of fungal meningitis?

Answer 12

cryptococcus

coccidiomycosis

Question 13

What are the causes of acute bacterial meningitis?

Answer 13

bacterial and viral

Question 14

What are the CSF findings in bacterial meningitis?
Glucose
Protein
WBC

Answer 14

Glucose: low to zero
Protein: high (up to a gram)
WBCs: PMNs 100s-1000s

Question 15

What are the CSF findings in viral meningitis?
Glucose
Protein
WBCs

Answer 15

glucose: normal (>50)
protein: high (100-300)
WBCs: lymphs 50-500

Question 16

What are the CSF findings in tuberculous meningitis?
Glucose
Protein
WBCs

Answer 16

Glucose: low: (10-40)
protein: high (100-300)
WBCs: PMNs and lymphs 100-500

Question 17

What are the CSF findings fungal meningitis?
Glucose
protein
WBCs

Answer 17

glucose: low (20-40)
protein: high (50-150)
WBCs: lymphs 25-100

Question 18

encephalitis is typically (blank) in etiology

Answer 18

viral

Question 19

What causes sporadic enceph?

Answer 19

HSV1

Question 20

epidemic encephalitis is (blank)-borne

Answer 20

insect borne

Question 21

Describe the CSF in viral encephalitis?

Answer 21

low normal or normal; protein elevated; lymphs 10-100s

Question 22

How can you Dx encephalitis via CSF?

Answer 22

PCR viral DNA/RNA

brain imaging

Question 23

meningoencephalitis is what?

Answer 23

meningitis and encephalitis simultaneously

Question 24

Brain abcesses are normally (singular/mixed) in bacterial etiology

Answer 24

mixed

Question 25

What is an opportunistic infx causing brain abscesses in AIDS?

Answer 25

toxoplasma gondii

Question 26

What are the ranges of symptoms in brain abscesses?

Answer 26

asymptomatic to wildly sympotmatic

Question 27

What is the Tx for a brain abscess?

Answer 27

Abx or Abx plus surgery

Question 28

What is the major cause of spinal abscesses?

Answer 28

Staph aureus

Question 29

What is the hallmark of an epidural abscess of the spinal cord?

Answer 29

PAIN

Question 30

T/F: spinal abscesses can be treated with or without surgery

Answer 30

false; neurosurgical emergency

Question 31

How do you Dx toxoplasmosis?

Answer 31

1. Serological via blood or CSF | 2. Direct ID of the parasite from peripheral blood, amniotic fluid, or in tissue sections

Question 32

T/F: both oocysts and tissue cysts from toxoplasma transform into tachyzoites after ingestion

Answer 32

true

Question 33

Tachyzoites of toxoplasma localize to what type of tissue?

Answer 33

neural tissue and muscle

Question 34

The form of toxoplasma present in tissue cysts are...

Answer 34

bradyzoites

Question 35

T/F: tachyzoites can cross the placenta and infect the fetus

Answer 35

true

Question 36

Are humans with toxoplasma infectious?

Answer 36

no, only the animal reservoirs

Question 37

HIV can result in what two brain issues?

Answer 37

HIV dementia/encephalopathy | HIV myelopathy

Question 38

What are the opportunistic neuro infections post HIV infx?

Answer 38

``` syphilitic meningitis cryptococcal meningitis toxo abscess CMV myelitis progressive multifocal encephalopathy (PML)>JC virus ```