coagulation

Question 1

intrinsic factors consist of what

Answer 1

12, 11, 9. kallikrein

Question 2

extrinisc

Answer 2

activation of 7 by tissue factor. also consists of 5, 10 and 2

Question 3

Prothrombin time (PT)

Answer 3

time to form clot with thromboplastin

Question 4

which pathway does PT measure

Answer 4

extrinsic

Question 5

PT used in patients taking what

Answer 5

oral anticoagulants (warfarin)

Question 6

Partial thromboplastin time (PPT)

Answer 6

time for plasma to form clot in presence of added ground glass or kaolin

Question 7

which pathway does PPT measure

Answer 7

intrinsic

Question 8

prolongued PT or PPT time means what

Answer 8

decreased number or abnormal factors (each one measures different factors)

Question 9

PPT used in patients take what

Answer 9

heparin

Question 10

bleeding time measures ____ function

Answer 10

platelet

Question 11

prolonged bleeding time means abnormalities in what

Answer 11

platelets

Question 12

If the mixing study corrects the clotting time, a deficiency of some _____ is felt to be present

Answer 12

factor(s)

Question 13

If the mixing study does not correct the clotting time, an _____ is felt to be present,

Answer 13

inhibitor

Question 14

Disorders of the _______ may be suspected if screening laboratory tests are normal.

Answer 14

regulatory system

Question 15

mucosal bleeding is associated with ______ problem

Answer 15

platelet

Question 16

deep tissue hematomas are associated with _____ problmes

Answer 16

coagulation factor

Question 17

Disorders of Primary Hemostasis: clinical presentation and lab results

Answer 17

clincal- mucocutaneous bleeding

lab- prolonged bleeding time and thrombocytopenia

Question 18

Disorders of Secondary Hemostasis: clinical presentation and lab results

Answer 18

clinical- soft tissue bleeding

lab- prolonged PT and/or PTT and/or thrombin time.

Question 19

Most common inherited bleeding disorder

Answer 19

vonWillebrand diease

Question 20

The predominant clinical manifestation of vWF disease is….

Answer 20

The predominant clinical manifestation is mucocutaneous bleeding. also nosebleeds, bruises,

Question 21

what is von willebrand disease

Answer 21

abnormal funtion or number of vWF

Question 22

Because vWF is a carrier for Factor VIII, the measured level of Factor VIII also _______

Answer 22

decreases

Question 23

lab manifestations of vWF disease

Answer 23

prolonged bleeding time, prolonged PPT

Question 24

Therapeutic options for vWF disease include

Answer 24

desmopressin- releases vWF from endothelial cells

Question 25

hemophilia A is what kind of genetic disease

Answer 25

Sex-linked recessive

Question 26

hemophilia A is due to what

Answer 26

decreased production of factor Vlll

Question 27

hemophilia A clinical manifestations include

Answer 27

hemarthrosis, soft tissue bleeding, bleeding with trauma, intramuscular hematomas, intracranial hemorrhage, and generally excessive bleeding.

Question 28

only abnormal lab test in hemophilia A is what?

Answer 28

PTT time due to factor 8 depletion

Question 29

factor 8 is associated with which test

Answer 29

PTT

Question 30

Generally thrombocytopenia is present when the platelet count is < than _______

Answer 30

100,000/µL

Question 31

petechial hemorrhages in skin and mucous membranes type of bleeding is associated with what

Answer 31

thrombocytopenia

Question 32

Immune Thrombocytopenic Purpura (ITP) is simply causes

Answer 32

bleeding

Question 33

what happens in Immune thrombocytopenic purpura

Answer 33

auto antibodies made against platelets, platelets get destoryed by spleen

Question 34

acute form ITP

Answer 34

1. children 2. severe thrombocytopenia 3. self limiting

Question 35

chronic ITP

Answer 35

1. adults | 2. less thormbocytopenia

Question 36

Thrombotic Thrombocytopenic Purpura (TTP): simply causes

Answer 36

clots, coagulation (platelet activation) microthrombi

Question 37

TTP is caused by a deficiency in

Answer 37

metalloproteinase, ADAMTS 13

Question 38

deficiency in metalloproteinase, ADAMTS 13

Answer 38

results in accumulation of the abnormally large vWF in the plasma.

Question 39

Disseminated Intravascular Coagulation (DIC)

Answer 39

uncontrolled activation of the hemostatic system

Question 40

Clinical situations with increased risk of occurrence of DIC include infections....

Answer 40

(Gram negative sepsis),