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HEMATOLOGY (HARR) > Coagulation and Fibrinolytic systems > Flashcards

Coagulation and Fibrinolytic systems Flashcards

1
Q

Which of the following initiates in vivo
coagulation by activation of factor VII?
A. Protein C
B. Tissue factor
C. Plasmin activator
D. Thrombomodulin

A

B

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2
Q

Which of the following clotting factors plays a role
in clot formation in vitro, but not in vivo? in vitro
clot formation and not in vivo coagulation?
A. VIIa
B. IIa
C. XIIa
D. Xa

A

C

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3
Q

The anticoagulant of choice for most routine
coagulation studies is:
A. Sodium oxalate
B. Sodium citrate
C. Heparin
D. Ethylenediaminetetraacetic acid (EDTA)

A

B

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4
Q

Which ratio of anticoagulant-to-blood is correct
for coagulation procedures?
A. 1:4
B. 1:5
C. 1:9
D. 1:10

A

C

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5
Q

Which ratio of anticoagulant-to-blood is correct
for coagulation procedures?
A. 1:4
B. 1:5
C. 1:9
D. 1:10

A

C

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6
Q

Which results would be expected for the
prothrombin time (PT) and activated partial
thromboplastin time (APTT) in a patient with
polycythemia?
A. Both prolonged
B. Both shortened
C. Normal PT, prolonged APTT
D. Both normal

A

A

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7
Q

What reagents are used in the PT test?
A. Thromboplastin and sodium chloride
B. Thromboplastin and potassium chloride
C. Thromboplastin and calcium
D. Actin and calcium chloride

A

C

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8
Q

Which test would be abnormal in a patient with
factor X deficiency?
A. PT only
B. APTT only
C. PT and APTT
D. Thrombin time

A

C

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9
Q

Which clotting factor is not measured by PT
and APTT tests?
A. Factor VIII
B. Factor IX
C. Factor V
D. Factor XIII

A

D

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10
Q

A modification of which procedure can be used to
measure fibrinogen?
A. PT
B. APTT
C. Thrombin time
D. Fibrin degradation products

A

C

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11
Q

Which of the following characterizes vitamin K?
A. It is required for biological activity of fibrinolysis
B. Its activity is enhanced by heparin therapy
C. It is required for carboxylation of glutamate
residues of some coagulation factors
D. It is made by the endothelial cells

A

C

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12
Q

Which statement about the fibrinogen/fibrin
degradation product test is correct?
A. It detects early degradation products (X and Y)
B. It is decreased in disseminated intravascular
coagulation (DIC)
C. It evaluates the coagulation system
D. It detects late degradation products (D and E)

A

D

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13
Q

Which of the following clotting factors are
measured by the APTT test?
A. II, VII, IX, X
B. VII, X, V, II, I
C. XII, XI, IX, VIII, X, V, II, I
D. XII, VII, X, V, II, I

A

C

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14
Q

Which of the following clotting factors are
measured by the APTT test?
A. II, VII, IX, X
B. VII, X, V, II, I
C. XII, XI, IX, VIII, X, V, II, I
D. XII, VII, X, V, II, I

A

C

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15
Q

Which coagulation test(s) would be abnormal in a
vitamin K–deficient patient?
A. PT only
B. PT and APTT
C. Fibrinogen level
D. Thrombin time

A

B

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16
Q

Which coagulation test(s) would be abnormal in a
vitamin K–deficient patient?
A. PT only
B. PT and APTT
C. Fibrinogen level
D. Thrombin time

A

B

17
Q

Which of the following is correct regarding the
international normalized ratio (INR)?
A. It uses the International Sensitivity Ratio (ISR)
B. It standardizes PT results
C. It standardizes APTT results
D. It is used to monitor heparin therapy

A

B

18
Q

Which of the following is correct regarding the
international normalized ratio (INR)?
A. It uses the International Sensitivity Ratio (ISR)
B. It standardizes PT results
C. It standardizes APTT results
D. It is used to monitor heparin therapy

A

B

19
Q

Which of the following is referred to as an
endogenous activator of plasminogen?
A. Streptokinase
B. Transamidase
C. Tissue plasminogen activator
D. Tissue plasminogen activator inhibitor

A

C

20
Q

Which protein is the primary inhibitor of the
fibrinolytic system?
A. Protein C
B. Protein S
C. α2-Antiplasmin
D. α2-Macroglobulin

A

C

21
Q

Which of the following statements is correct
regarding the D-dimer test?
A. Levels are decreased in DIC
B. Test detects polypeptides A and B
C. Test detects fragments D and E
D. Test has a negative predictive value

A

D

22
Q

A protein that plays a role in both coagulation and
platelet aggregation is:
A. Factor I
B. Factor VIII
C. Factor IX
D. Factor XI

A

B

23
Q

A standard 4.5-mL blue-top tube filled with 3.0 mL
of blood was submitted to the laboratory for PT
and APTT tests. The sample is from a patient
undergoing surgery the following morning for a
tonsillectomy. Which of the following is the
necessary course of action by the technologist?
A. Run both tests in duplicate and report the
average result
B. Reject the sample and request a new sample
C. Report the PT result
D. Report the APTT result

A

B

24
Q

Which statement is correct regarding sample
storage for the prothrombin time test?
A. Stable for 24 hours if the sample is capped
B. Stable for 24 hours if the sample is refrigerated
at 4°C
C. Stable for 4 hours if the sample is stored at 4°C
D. Should be run within 8 hours

A

A

25
Q

Which statement is correct regarding sample
storage for the prothrombin time test?
A. Stable for 24 hours if the sample is capped
B. Stable for 24 hours if the sample is refrigerated
at 4°C
C. Stable for 4 hours if the sample is stored at 4°C
D. Should be run within 8 hours

A

A

26
Q

Plasminogen deficiency is associated with:
A. Bleeding
B. Thrombosis
C. Increased fibrinolysis
D. Increased coagulation

A

B

26
Q

In primary fibrinolysis, the fibrinolytic activity
results in response to:
A. Increased fibrin formation
B. Spontaneous activation of fibrinolysis
C. Increased fibrin monomers
D. DIC

A

B

27
Q

Which of the following clotting factors are
activated by thrombin that is generated by tissue
pathway (TF-VIIa)?
A. XII, XI
B. XII, I
C. I, II
D. V, VIII

A

D

28
Q

What substrate is used in a chromogenic factor
assay?
A. p-nitroanaline
B. Chloropheonol red
C. Prussian blue
D. Ferricyanide

A

A

29
Q

Which of the following antibodies is used in the
D-dimer assay?
A. Polyclonal directed against X and Y fragments
B. Polyclonal directed against D-dimer
C. Monoclonal against D and E fragments
D. Monoclonal against D-dimer

A

D

HEMATOLOGY (HARR) (11 decks)

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