Colorectal Cancer 67

Question 1

Mode of inheritance of Peutz-Jegher’s syndrome

Answer 1

Autosomal dominant
STK11 gene on Ch.19p

Question 2

Mode of inheritance of Familial Adenomatous Polyposis (FAP)

Answer 2

AD
APC gene (5q21)

Question 3

Mode of inheritance of Lynch syndrome (HNPCC)

Answer 3

AD
(high frequency Microstaellite instability)

Question 4

When to screen for CRC in a patient with +ve family History (first degree relative at age 60 or older) ?

Answer 4

According to ACG Guidelines:
Begin at age 50 and repeat every 10 yrs

Question 5

When to screen for CRC in a patient with +ve family History (first degree relative at age 60 or two or more 1st degree relatives had CRC at any age) ?

Answer 5

At age 40 or 10 yrs before the youngest repative’s diagnosis
And repeat every 5 yrs

Question 6

When to screen for CRC in a patient with No family History (Average risk population)

Answer 6

. Start at age 50 or 60 depending on the guidelines.
. Repeat every 1-2 yrs

Question 7

Method of screening of CRC in average risk population(-ve FH)

Answer 7

Start with FOBT, then if +ve proceed with colonoscopy