Complement System Flashcards
What combination will take up an added complement ?
Ab Ag plus a fixed amount of pre-titrated complement where if the Ag and Ab are specific to one another they will combine
C1 and c4 are involved in ?
Neutralisation of viruses
Complement mediates the attack on invading microorganisms. True or False ?
True
What is the function of antibodies ?
1) identify the invading organisms as foreign
2) activate the attack of complements
C3 and C5 are involved in ?
Inflammation response
What is the most important thing in complement fixation test ?
The sequence of the reaction that leads to damage of cell membranes
For complement fixation test, what temp and time should serum be heated for ?
30 minutes at 56°C
What are the processes the complement system sets in motion to destroy foreign cells ?
1) cell lysis
2) opsonization
3) inflammation
What complement binds ro microbes where neutrophils and macrophages have specific binding sites for it ?
C3
Membrane dange that can cause destruction of bacteria by rupture, so that the cells release their contents is described as ?
Cell lysis
Activation of the complement system can lead to ?
1) Production of biologically active factors
2) pathological processes
3) Damage of cell membrane
Testing for the presence of free, unattended complements is done by ?
Addition of RBC’s sensitised with haemolysis
What 2 distinct reactions does complement fixation test depend on ?
1) Ag-Ag + a fixed amount of pre-titrated complement. Where if the Ag and Ab are specific to each other they will combine
2) testing for the presence of free, unattended components
Complement system is activated by ?
Ig-M and Ig-G
Explain cell lysis
The full complement system leading to membrane damge can cause the destruction of some bacteria by rupture, so that the cells release their contents
Explain inflammation
Chemotaxis of phagocytic cell towards the microbes and the increase in vascular permeability that is seen as a function of acute inflammation are products of the release of small fragments of complement components during the course of activation
Explain opsonization
The activated C3 molecules bond to microorganisms where neutrophils and macrophages have specific binding sites for C3, thus facililitating phagocytosis of the coated organisms
Tissue transplantation ?
The process of transferring tissues or organs from one site to another
