Complicated Pregnancy: Pregnancy complications Flashcards
Life- threatening complications pre-eclampsia gestational diabetes Obstetric haemorrhage VTE Sepsis Maternal collapse (89 cards)
What is obstetric cholestasis?
Disorder characterised by maternal pruritus, liver dysfunction in the absence of contributing liver disorders and restricted to pregnancy
Caused by hormonal, genetic and environmental factors
Risk of obstetric cholestasis for the baby?
Spontaneous preterm birth
Meconium stained amniotic fluid
Neonatal unit admission
Stillbirth )If the mothers serum bile acids raise > 100micromol/L)
Maternal risks/complications of obstetric cholestasis?
Increased risk of gestational diabetes
Pre-eclampsia
Impaired glucose tolerance
Dyslipidaemia
Presentation of patient with Obstetric Cholestasis?
Mild jaundice
Pruritus particularly on soles of feet and palms of hands
Fatigue, dark urine, greasy pale stools
No rash present
Investigations for pts with Obstetric Cholestasis?
LFTs- raised bilirubin
Do viral screen- Hep A, B, C
EBV and CMV
Liver autoimmune antibodies- chronic hepatitis
Cholesterol- acute fatty liver
RULE ABOVE OUT- if still high LFTs and higher bile acids— this is obstetric cholestasis
RF for obstetric cholestasis?
Family hx
Previous hx of obstetric cholestasis
Hx of Hep C infection
Cholelithiasis - when gallstones cause symptoms or complications
Multi-fetal pregnancy
DDx for obstetric cholestasis?
Acute viral hep
Fatty liver of pregnancy
Gallstones
Autoimmune hepatitis
HELLP syndrome
Physiology of normal placentation?
Trophoblast invades the myometrium and the spiral arteries of the uterus–> destroying the tunica muscularis media
Renders spiral arteries dilated–> unable to constrict–> pregnancy with a high flow and low resistance circulation
Pathophysiology of placentation in pre-eclampsia?
Remodelling of spiral arteries=incomplete
High resistance, low flow uteroplacental circulation develops, as the constrictive muscular walls of spiral arteries are maintained–> increased BP
Increased BP with hypoxia and oxidative stress from inadequate uteroplacental perfusion–> systemic inflammatory response and endothelial cell dysfunction
Moderate risk factors for pre-eclampsia?
Nuliparity
Maternal age> 40 years
Maternal BMI > 35 at inital presentation
Family hx of pre-eclampsia
Pregnancy interval > 10 years
Multiple pregnancy
High risk factors for Pre-eclampsia?
chronic hypertension
HTN, pre-eclampsia or eclampsia in previous pregnancy
Autoimmune disorder
Type 1 or Type 2 DM
CKD
How do you manage the risk of pre-eclampsia?
If a pt has one or more high RF or 2 or more moderate RF:
Aspirin 75mg-150mg daily from 12 weeks gestation until the birth
Triad of pre-eclampsia?
New onset hypertension
Oedema
Proteinuria
(POOH = Protein, Odema, (new)Onset Hypertension)
What is the definition of pre-eclampsia?
New onset BP greater than and equal to 140/90 after 20 weeks
AND, one or more of the following:
Proteinuria
Other organ involvement e.g. renal insufficiency, liver, neuro, haem or uteroplacental dysfunction
Features of Pre-eclampsia
i.e. what can it progress to? Fetal complications? any other organ involvement?
May progress to eclampsia: other neuro complications incl altered mental state, blindness, convulsions, severe headaches, clonus, stroke, persistent visual scotomata
Fetal complications (IUGR, prematurity)
Liver involvement
Haemorrhage: placental abruption, intra-abdominal, intra-cerebral, cardiac failure
Features of SEVERE pre-eclampsia?
Hypertension ( greater than or equal to 160/110)
Proteinuria: Dipstick ++/+++
Headache
Papilloedema
Visual disturbances
RUQ/epigastric pain
Hyperreflexia
Platelet count < 100 x 106, abnormal liver enzymes or HELLP
Classification of pre-eclampsia?
Mild: BP 140/90-149/99 mmHg
Moderate: BP 150/100 – 159/109 mmHg
Severe: BP > 160/110 + proteinuria > 0.5 g/ day
or
BP > 140/90 mmHg + proteinuria + symptoms.
Maternal complications of pre-eclampsia?
Eclampsia
AKI
HELLP syndrome
DIC
ARDS
HTN (post partum as well)
Death
Ddx of pre-eclampsia?
Chronic HTN
Gestational HTN
Epilepsy
Liver disease
What is HELLP syndrome
Complication of pre-eclampsia
Patient has haemolysis, elevated liver enzymes and low platelets
Investigations in pre-eclampsia?
Urinalysis- first dipstick and then 24 hour collection ( > or equal to 300mg of protein in 24 hours is diagnostic)
BP
FBC- may see reduced Hb, reduced platelets
U&Es- may see increased urea and creatinine and reduced output due to renal involvement
LFTS- may see elevated enzymes due to hepatic involvement
Management of pre-eclampsia
Frequent monitoring via regular blood pressure measurements, urinalysis, blood tests, fetal growth scans and cardiotocography
VTE prevention: most women are managed as an inpatient and given LMWH
Anti-hypertensives: Labetalol first line, Nifedipine is 2nd line (e.g. asthma)
Delivery is the only definite cure:
**Where a woman is less than 35 weeks’ gestation, and delivery is considered, intramuscular steroids should be administered to aid development of the fetal lungs.
Management of eclampsia?
- DRABCDE
- Magnesium sulfate 4g bolus over 10 minutes followed by 1g/hour for 24 hours
What is eclampsia?
Eclampsia may be defined as the development of seizures in association pre-eclampsia.