Complicated Pregnancy: Pregnancy complications Flashcards

Life- threatening complications pre-eclampsia gestational diabetes Obstetric haemorrhage VTE Sepsis Maternal collapse (89 cards)

1
Q

What is obstetric cholestasis?

A

Disorder characterised by maternal pruritus, liver dysfunction in the absence of contributing liver disorders and restricted to pregnancy

Caused by hormonal, genetic and environmental factors

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2
Q

Risk of obstetric cholestasis for the baby?

A

Spontaneous preterm birth
Meconium stained amniotic fluid
Neonatal unit admission
Stillbirth )If the mothers serum bile acids raise > 100micromol/L)

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3
Q

Maternal risks/complications of obstetric cholestasis?

A

Increased risk of gestational diabetes
Pre-eclampsia
Impaired glucose tolerance
Dyslipidaemia

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4
Q

Presentation of patient with Obstetric Cholestasis?

A

Mild jaundice
Pruritus particularly on soles of feet and palms of hands

Fatigue, dark urine, greasy pale stools
No rash present

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5
Q

Investigations for pts with Obstetric Cholestasis?

A

LFTs- raised bilirubin

Do viral screen- Hep A, B, C
EBV and CMV
Liver autoimmune antibodies- chronic hepatitis
Cholesterol- acute fatty liver
RULE ABOVE OUT- if still high LFTs and higher bile acids— this is obstetric cholestasis

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6
Q

RF for obstetric cholestasis?

A

Family hx
Previous hx of obstetric cholestasis
Hx of Hep C infection
Cholelithiasis - when gallstones cause symptoms or complications
Multi-fetal pregnancy

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7
Q

DDx for obstetric cholestasis?

A

Acute viral hep
Fatty liver of pregnancy
Gallstones
Autoimmune hepatitis
HELLP syndrome

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8
Q

Physiology of normal placentation?

A

Trophoblast invades the myometrium and the spiral arteries of the uterus–> destroying the tunica muscularis media

Renders spiral arteries dilated–> unable to constrict–> pregnancy with a high flow and low resistance circulation

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9
Q

Pathophysiology of placentation in pre-eclampsia?

A

Remodelling of spiral arteries=incomplete

High resistance, low flow uteroplacental circulation develops, as the constrictive muscular walls of spiral arteries are maintained–> increased BP

Increased BP with hypoxia and oxidative stress from inadequate uteroplacental perfusion–> systemic inflammatory response and endothelial cell dysfunction

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10
Q

Moderate risk factors for pre-eclampsia?

A

Nuliparity
Maternal age> 40 years
Maternal BMI > 35 at inital presentation
Family hx of pre-eclampsia
Pregnancy interval > 10 years
Multiple pregnancy

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11
Q

High risk factors for Pre-eclampsia?

A

chronic hypertension
HTN, pre-eclampsia or eclampsia in previous pregnancy
Autoimmune disorder
Type 1 or Type 2 DM
CKD

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12
Q

How do you manage the risk of pre-eclampsia?

A

If a pt has one or more high RF or 2 or more moderate RF:
Aspirin 75mg-150mg daily from 12 weeks gestation until the birth

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13
Q

Triad of pre-eclampsia?

A

New onset hypertension
Oedema
Proteinuria

(POOH = Protein, Odema, (new)Onset Hypertension)

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14
Q

What is the definition of pre-eclampsia?

A

New onset BP greater than and equal to 140/90 after 20 weeks
AND, one or more of the following:
Proteinuria
Other organ involvement e.g. renal insufficiency, liver, neuro, haem or uteroplacental dysfunction

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15
Q

Features of Pre-eclampsia

i.e. what can it progress to? Fetal complications? any other organ involvement?

A

May progress to eclampsia: other neuro complications incl altered mental state, blindness, convulsions, severe headaches, clonus, stroke, persistent visual scotomata

Fetal complications (IUGR, prematurity)

Liver involvement

Haemorrhage: placental abruption, intra-abdominal, intra-cerebral, cardiac failure

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16
Q

Features of SEVERE pre-eclampsia?

A

Hypertension ( greater than or equal to 160/110)

Proteinuria: Dipstick ++/+++

Headache

Papilloedema

Visual disturbances

RUQ/epigastric pain

Hyperreflexia

Platelet count < 100 x 106, abnormal liver enzymes or HELLP

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17
Q

Classification of pre-eclampsia?

A

Mild: BP 140/90-149/99 mmHg
Moderate: BP 150/100 – 159/109 mmHg
Severe: BP > 160/110 + proteinuria > 0.5 g/ day
or
BP > 140/90 mmHg + proteinuria + symptoms.

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18
Q

Maternal complications of pre-eclampsia?

A

Eclampsia
AKI
HELLP syndrome
DIC
ARDS
HTN (post partum as well)
Death

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19
Q

Ddx of pre-eclampsia?

A

Chronic HTN
Gestational HTN
Epilepsy
Liver disease

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20
Q

What is HELLP syndrome

A

Complication of pre-eclampsia

Patient has haemolysis, elevated liver enzymes and low platelets

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21
Q

Investigations in pre-eclampsia?

A

Urinalysis- first dipstick and then 24 hour collection ( > or equal to 300mg of protein in 24 hours is diagnostic)
BP

FBC- may see reduced Hb, reduced platelets
U&Es- may see increased urea and creatinine and reduced output due to renal involvement
LFTS- may see elevated enzymes due to hepatic involvement

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22
Q

Management of pre-eclampsia

A

Frequent monitoring via regular blood pressure measurements, urinalysis, blood tests, fetal growth scans and cardiotocography

VTE prevention: most women are managed as an inpatient and given LMWH

Anti-hypertensives: Labetalol first line, Nifedipine is 2nd line (e.g. asthma)

Delivery is the only definite cure:

**Where a woman is less than 35 weeks’ gestation, and delivery is considered, intramuscular steroids should be administered to aid development of the fetal lungs.

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23
Q

Management of eclampsia?

A
  1. DRABCDE
  2. Magnesium sulfate 4g bolus over 10 minutes followed by 1g/hour for 24 hours
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24
Q

What is eclampsia?

A

Eclampsia may be defined as the development of seizures in association pre-eclampsia.

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25
1. Use of magnesium sulphate in eclampsia? 2. what should you monitor after giving woman magnesium sulfate?
1. prevent seizures in patients with severe pre-eclampsia and treat seizures once they develop. 2. monitor reflexes and respiratory rate
26
How to do you treat eclampsia?
Magnesium sulphate should be given as soon as the decision to deliver has been made IV bolus of 4g over 5-10 minutes should be given followed by an infusion of 1g / hour urine output, reflexes, respiratory rate and oxygen saturations should be monitored during treatment respiratory depression can occur: calcium gluconate is the first-line treatment for magnesium sulphate induced respiratory depression treatment should continue for 24 hours after last seizure or delivery (around 40% of seizures occur post-partum)
27
What is placenta praevia?
Placenta fully or partially attached to the lower uterine segment Cause of antepartum haemorrhage
28
What is antepartum haemorrhage?
Vaginal bleeding from week 24 gestation until delivery
29
What are the 2 main types of placenta praevia?
Minor placenta praevia- placenta is low but does not cover the internal cervical os Major placenta praevia- placenta lies over the internal cervical os.
30
What can trigger haemorrhage in placenta praevia?
Spontaneous Mild trauma e.g. vaginal examination May get damaged as the presenting part of the fetus moves into lower uterine segment
31
RF for placenta praevia?
Multiparity Multiple pregnancy Maternal age>40 Previous placenta praevia Lower segment scar History of uterine infection (endometriosis)
32
Clinical features of placenta praevia?
Shock in proportion to visible loss no pain uterus NOT tender lie and presentation may be abnormal Fetal HR usually normal Coagulation problems rare Small bleeds before large
33
When should you be suspicious of ?placenta praevia
Any women presenting with painless vaginal bleeding May be spotting to massive haemorrhage
34
Questions to ask a woman who presents with antepartum haemorrhage?
How much bleeding was there and when did is start? Was it fresh red or old brown blood, or was it mixed with mucus? Could the waters have broken (membranes ruptured?) Was it provoked (post-coital) or not? Is there any abdominal pain? Are the fetal movements normal? Are there any risk factors for abruption? e.g. smoking/drug use/trauma – domestic violence is an important cause. IF bleed is ongoing or there is a significant vaginal bleed- A-E if the woman is clinically stable proceed to examination
35
How to exam a woman with antepartum haemorrhage?
Pallor, distress, check capillary refill, are peripheries cool? Is the abdomen tender? Does the uterus feel ‘woody’ or ‘tense’ (which may indicate placental abruption)? Are there palpable contractions? Check the lie and presentation of the fetus/fetuses. Ultrasound can be used to help. Check fetal wellbeing with a cardiotocograph (CTG) at 26 weeks gestation or above: (otherwise auscultate the fetal heart only). Read the hand-held pregnancy notes: are there scan reports? This will be helpful in establishing whether there could be placenta praevia
36
How do you diagnose placenta praevia?
Digital vaginal exam should NOT be performed before an USS as it may provoke severe haemorrhage Often picked up on the 20 week abdominal USS Use of transvaginal USS improves accuracy and is considered safe
37
Classical grading of placental praevia?
I- placenta reached lower segment but not the internal os II- placenta reaches internal os but doesn't cover it III- placenta covers the internal os before dilation but not when dilated IV (major)- placenta cover the internal os
38
Ddx of placenta praevia?
Placental abruption Vasa praevia Uterine rupture Benign or malignant lesions e.g. polyps, carcinoma, cervical ectropion Infections e.g. candida, BV and chlamydia
39
Investigations of placenta praevia/ any major bleeding?
FBC- assess any maternal anaemia Clotting profile Kleinbauer test- if women is Rhesus Negative ( to determine the amount of feto-maternal haemorrhage and thus the dose of anti-D required Group and Save Crossmatch- if we need to transfuse U&Es and LFTs to exclude any pre-eclampsia or HELLP syndrome Assess fatal wellbeing using CTG Definitive diagnosis is via USS
40
Management of placenta praevia?
Usually identified in an asymptomatic patient at their 20 week USS Placenta praevia minor- repeat scan at 36 weeks is recommended as the placenta is likely to have moved superiorly Placenta praevia major- repeat scan at 32 weeks is recommended and a plan for delivery should be made at this point Placenta praevia usually warrants an elective C-section- usually at 38 weeks
41
Management of obstetric cholestasis?
Induction of labour at 37-38 weeks Ursodeoxycholic acid Vit K supplementation
42
What is placental abruption?
Seperation of a normally sited placenta from the uterine wall resulting in maternal haemorrhage into the intervening space
43
Risk factors for placental abruption?
Proteinuric hypertension Cocaine use Multiparity Maternal trauma Increasing maternal age
44
Clincal features of placental abruption?
* Shock out of keeping with visible loss * pain constant * tender, tense uterus * normal lie and presentation * fetal heart: absent/distressed * coagulation problems * BEWARE pre-eclampsia, DIC, anuria
45
Managment of placental abruption?
Fetus alive < 36 weeks * fetal distress: immediate caesarean * no fetal distress: observe closely, steroids, no tocolysis, threshold to deliver depends on gestation Fetus alive > 36 weeks * Fetal distress: immediate caesarean * no fetal distress: deliver vaginally Fetus dead * Induce vaginal delivery *
46
Complictions of placental abruption?
Maternal: * shock * DIC * renal failure * PPH Fetal * IUGR * hypoxia * death
47
Prognosis of placental abruption?
* associated with high perinatal mortality rate * responsible for 15% of perinatal deaths
48
How may someone with placental abruption present?
Painful vaginal bleeding Woody uterus and painful on palpation
49
Types of Placental abruption?
* Revealed: bleeding tacks down from the site of placental separation and drains through the cervix. This results in vaginal bleeding * Concealed: bleeding remains within the uterus and typically forms a clot retroplacentally. This bleeding is not visible but usually enough to cause systemic shock
50
DDx for placental abruption?
* Placenta praevia * Marginal placental bleed * Vasa praevia * Uterine rupture * Local genital causes e.g. polyps or infections
51
What is vasa praevia?
Where fetal blood vessels run near the internal cervical os. Triad of: * vaginal bleeding * Rupture of membranes * Fetal compromise
52
What is gestational diabetes?
Any degree of glucose intolerance with onset or first recognition during pregnancy
53
Pathophysiology of gestational diabetes?
Progressive insulin resistance in pregnancy Woman with borderline pancreatic reserve is unable to respond to the increased insulin requirements, resulting in transient hyperglycaemia.
54
RF for gestational DM?
* BMI>30kg/m2 * previous macrosomic baby weighing 4.5kg or above * previous gestational DM * first degree relative with DM * South asian/black caribbean/Middle eastern
55
Clinical features of gestational DM?
may be asymptomatic polyuria polydipsia fatigue
56
Fetal complications of gestational DM?
Fetus has hyperinsulinaemia due to increased glucose. Insulin is similar structure to growth hormones so: * Macrosomia-> lead to labour complications e.g. shoulder dsytocia * Organomegaly * Erythropoiesis * Polyhydramnios * Increased rates of pre-term delivery After delivery, baby has been used to high glucose, risk of becoming hypoglycaemic- needs regular feeding High insulin can cause reduction in pulmonary phospholipids--> high risk of transient tachypnoea of the newborn
57
Investigations for gestational diabetes?
Oral glucose tolerance test: fasting plasma glucose is measured, then 75g glucose drink is given- with a repeat plasma glucose measurement after 2 hours Fasting glucose > 5.6mmol/L 2hrs postprandial glucose > 7.8 mmol/L
58
When is the oral glucose tolerance test offered?
Booking- if previous gestational diabetes 24-28 weeks gestation- if RF are present, or if previous gestational DM Any point during pregnancy- if 2+ glycosuria on one occasion, or 1+ on 2 occasions
59
Managemnt of gestation DM?
* newly diagnosed women should be seen in a joint diabetes and antenatal clinic within a week * women should be taught about self-monitoring of blood glucose * advice about diet and exercise should be given if the fasting plasma glucose level is < 7 mmol/l a trial of diet and exercise should be offered * if glucose targets are not met within 1-2 weeks of altering diet/exercise metformin should be started * if glucose targets are still not met insulin should be added to diet/exercise/metformin * gestational diabetes is treated with short-acting, not long-acting, insulin * if at the time of diagnosis the fasting glucose level is >= 7 mmol/l insulin should be started * if the plasma glucose level is between 6-6.9 mmol/l, and there is evidence of complications such as macrosomia or hydramnios, insulin should be offered * glibenclamide should only be offered for women who cannot tolerate metformin or those who fail to meet the glucose targets with metformin but decline insulin treatment
60
What are the self-monitoring glucose targets for women with GDM or DM?
Fasting: 5.3mmol/L 1 hour after meals: 7.8 mmol/L 2 hour after meal: 6.4 mmol/L
61
Post-partum management of GDM?
All diabetic medication stopped immediately after delivery. Blood glucose checked and ensured it has returned to normal before discharge 6-13 week post partum, fasting glucose test is recommended, if normal, tests should be offered yearly
62
Why is pregnancy a RF for VTE?
As you are hypercoaguable
63
When is pregnant lady considered high risk for VTE?
If had previous VTE
64
When is a pregant lady considered intermediate risk of developing VTE?
Hospitalisation Surgery Co-morbities Thrombophilia
65
Other RF for VTE?
Age > 35 Body mass index > 30 Parity > 3 Smoker Gross varicose veins Current pre-eclampsia Immobility Family history of unprovoked VTE Low risk thrombophilia Multiple pregnancy IVF pregnancy
66
When do you treat a pregnant lady for VTE?
4 or more risk factors: immediate treatment with LMWH until 6 weeks postnatally 3 risk factors LMWH should be initaited from 28 weeks and continued until 6 weeks postnatally
67
Management for a pregnant patient with a DVT?
Continue anticoagulation treatment for at least 3 months
68
Clinical features of DVT?
Unilateral leg swelling and leg pain Pyrexia Pitting oedma Tenderness Prominent superficial veins
69
Clincial features of PE?
Sudden onset dyspnoea Pleuritic chest pain Cough Haemoptysis Signs: tachycardia, tachypnoea, pyrexia, raised JVP or pleural rub or pleural effusion
70
DDx DVT
Cellulitis ruptured Baker's cyst Superficial vein thrombophlebitis
71
PE Ddx?
ACS Aortic dissection Pneumonia Pneumothorax
72
Do you do a D-dimer in a pregnant woman with a suspected DVT?
NO! D-dimer will normally be raised in pregnancy
73
Women who are on LMWH due to DVT prophylaxis should stop their dose before induction/c-section. True or false?
TRUE- omit the dose 24 hours before any planned induction of labour or C-section. They should not take their dose if they think they are going into labour
74
How assess bleeding in a pregnant lady?
Externally- look at pads Cusco speculum exam- avoid until placenta praevia has been excluded by USS. Look for whether blood is fresh or dark, how much blood, are they are clots, are there any cervical lesions, is there any cervical dilatation, or any chance have membranes ruptured Take triple genital swabs to exclude infection if the bleeding is minimal DVE: contraindicated in PLACENTA PRAEVIA, if excluded- can help to see whether cervix if dilated, avoid if membranes have ruptured
75
Causes of bleeding in 1st trimester of pregnancy?
Spontaneous abortion Ectopic pregnancy Hydatidiform mole
76
Cause of bleeding 2nd trimester pregnancy?
Spontaneous abortion Hydatidiform mole Placental abruption
77
Cause of bleeding 3rd trimester
Bloody show Placental abruption Placenta praevia Vasa praevia
78
What is hydatiform mole?
Typically bleeding in first or early second trimester associated with exaggerated symptoms of pregnancy e.g. hyperemesis. The uterus may be large for dates and serum hCG is very high
79
How does BP change in pregnancy?
BP usually falls during the 1st trimester and continues to fall until 20-24 weeks After this time the BP usually increases to pre-pregnancy levels by term
80
Prophylaxis for women at risk of developing pre-eclapmsia?
75mg aspirin od from 12 weeks until babys birth
81
Criteria for HTN in pregnancy?
systolic > 140 mmHg or diastolic > 90 mmHg or an increase above booking readings of > 30 mmHg systolic or > 15 mmHg diastolic
82
Mangement of HTN in pregnancy?
Oral labetalol Oral nifedipine and hydralazine (2nd line)
83
HTN in pregnancy vs pre-eclampsia?
HTN: hypertension after 20 weeks in pregnancy Pre-eclampsia: hypertension associated with proteinuria (>0.3g/24 hrs)
84
What is maternal collapse?
acute event involving the cardiorespiratory systems and/or central nervous system resulting in a reduced or absent conscious level (and potentially cardiac arrest and death), at any stage in pregnancy and up to 6 weeks after birth
85
Causes of Maternal collapse?
5H's Hypovolaemia Hypoxia Hypo/hyperkalaemia Hypo/hypernatraemia Hypothermia 4T's Thromboembolism Toxicity Tension pneumothorax Tamponade Eclampia and pre-eclampsia Intracranial haemorrhage
86
Mangement of maternal collapse?
ABCDE approach If pt RESPONDS: 2222- obstetric emergency call Place in left lateral position if TILTED in theatres or if outside this environment, manually and generally displace the uterus to relieve aortocaval compression Give high flow oxygen- SATS of at least 94% Commence MEOWS chart if not already in use and escalate appropriately Assess fetal wellbeing Check blood glucose level Insert 16G IV cannula Take bloods for: FBC, G&S or crossmatch 4 units U&Es Clotting studies ABG/VBG and lactate Blood cultures should be obtained by separate venous stab as per trust guidelines NO RESPONSE 2222 Maternal cardiac arrest Ensure manual uterine displacement in women above 20 weeks gestation or where the uterus is palpable at or above the level of the umbilicus.
87
When is perimorten c-section (PMCS) indicated in maternal collapse?
Interests of maternal survival In women over 20 weeks gestation, if not response to CPR within 4 mins of maternal collapse or resuscitation is continued beyond this, the PMCS should be undertaken. Should be achieved within 5 mins of collapse
88
Pt with suspected ?PE
Baseline bloods- LFTS, U&Es for how LMWH will be metabolised Treat with LMWH Arrange imaging- V/Q scan or CTPA CTPA- increase risk of childhood leukaemia V/Q- small risk of breast cancer Counsel pts on risk
89
How does eclampsia impact management of the third stage of labour?
In eclamptic patients, management of the third stage of labour should be with oxytocin and not syntometrine/ergometrine because of the risk of increased BP. | quesmed