Compounding

Question 1

USP 795

Answer 1

Non-sterile compounding

Question 2

USP 797

Answer 2

Sterile compounding

Question 3

USP 800

Answer 3

Handling hazardous drugs

Question 4

NIOSH

Answer 4

Determines which drugs are hazardous

Question 5

ISO

Answer 5

Sets standards for air quality

Which is determined by the number of particles per volume of air of a specified particle size

Question 6

ISO for critical areas (inside the hood)

Answer 6

ISO 5

Question 7

ISO for buffer room or anteroom

Answer 7

ISO 7

Question 8

A graduate should not be used to measure volumes less than ____ of the graduate’s capacity

Answer 8

20%

Question 9

Surfactant

Answer 9

Lowers the Surface Tension between two ingredients to make then more miscible or easier to mix together

Question 10

Emulsion

Answer 10

Liquid dispersed in a different liquid

Question 11

Oxidation

Answer 11

Loses electrons

Question 12

Reduction

Answer 12

Gains of electrons

Question 13

Hydrolysis

Answer 13

Water causes the cleavage of a bond in a molecule

Question 14

What 3 functional groups are susceptible to hydrolysis

Answer 14

Esters

Amides

Lactams

Question 15

Photolysis

Answer 15

UV light exposure causes breakage of covalent bonds

Question 16

4 compounds sensitive to lights

Answer 16

Ascorbic acid (Vitamin C)

Folic acid (Vitamin B9)

Nitroprusside (a vasodilator like Nitrostat)

Phytonadione (Vitamin K1)

Question 17

Ointment, Cream or Lotion …… Which has more water?

Answer 17

Ointment: 80-100% oil 0-20% water

Cream: 50:50 oil and water

Lotion: most water

Question 18

Solution

Answer 18

A solute dissolved in a solvent

Question 19

Suspension

Answer 19

Solid dispersed in a liquid

Question 20

Eutectic mixture

Answer 20

The combination of the ingredients when mixed will melt at a lower temperature than either of their individual melting temperatures

Question 21

BUD for non-aqueous formulations

Answer 21

Earliest expiration date

or

6 months

Question 22

BUD for Water-containing oral formulations

Answer 22

14 days

Question 23

BUD for Water containing topical semisolid form

Answer 23

30 days

Question 24

Low-risk sterile compounding

Answer 24

Uses 1 - 3 additives that are supplied as sterile

Question 25

Medium-risk sterile compounding

Answer 25

Uses more than 3 additives that are sterile

Question 26

High-risk sterile compounding

Answer 26

Non-sterile ingredients and equipment

Question 27

Osmolarity

Answer 27

Express the solute concentration and includes all solutes

Question 28

Tonicity

Answer 28

Express the solute concentration and includes only the solutes that do not cross the vasculature

Question 29

What happens when you inject hypertonic saline in a peripheral vein

Answer 29

The high concentration of solutes relative to the concentration in blood will cause water to move out of the red blood cells, in an attempt to dilute the solute concentration

Question 30

What is the highest acceptable Osmolarity allowed for peripheral IV?

Answer 30

~900 mOsmol/L | anything higher than this should be administered in a central line

Question 31

What happens when a preparation has lower osmolarity than blood

Answer 31

RBC absorb fluid causing hemolysis

Question 32

What is the lowest osmolarity that should be administered IV

Answer 32

~154 mOsmol/L | this is the osmolarity of 1/2 normal saline