Comprehensive Review

Question 1

Primary goal of immunolgy

Answer 1

Immunity

Question 2

Discovered cellular theory of immunity

Answer 2

Metchnikoff 1883 to 1905

Question 3

Prevents entry and establishment of pathogen in the body

Answer 3

External defence system

Question 4

Bridges innate and adaptive immunity

Largest lymphocyte

Answer 4

Nk cells

Question 5

Multicolony stimulating factor

Answer 5

IL 3

Question 6

Alpha 1 antirtrypsin deficiency

Answer 6

Premature emphysema/liver dse

Question 7

Most potent opsonin

Answer 7

CRP

Question 8

Location of MHC

Answer 8

Chromosome 6p

Question 9

Most potent APC

Answer 9

Dendritic cells

Question 10

Massive overproduction of cytokine leading to shock , multi organ failure

Answer 10

Cytokine storm

Question 11

Rearrangement of genes coding for heavy and light chains of antibody

Answer 11

Pro b cells

Question 12

Synthesis of heavy chain

Answer 12

Pre B cell

Question 13

Immunohlobulin present in mature B cells

Answer 13

Surface IgD and IgM

Question 14

Most efficient in fixing complement

Answer 14

IgG3

Question 15

who developed the side chain theory of anti-body?

Answer 15

Ehrlich

Question 16

steps in PCR

Answer 16

Denaturation- heat at 95
annealing-cool to 52
Elongation-72

Question 17

at which stage of syphilis does hard chancre be seen

Answer 17

Primary

Question 18

confirmatory test of HIV in the Philippines

Answer 18

RHIVDA

Question 19

what are the bands present in the confirmatory test of HIV

Answer 19

p24, GP 120/160, gp41

Question 20

screening test for HIV

Answer 20

ELISA

Question 21

A marker of hepatitis that shows immunity

Answer 21

Anti-HBs

Question 22

A marker of hepatitis that shows recovery

Answer 22

Anti-HBe

Question 23

A lifelong marker of hepatitis

Answer 23

IgG Anti-HBc

Question 24

A marker of hepatitis that shows current or recent infection “Core Window Period”

Answer 24

IgM Anti-HBc

Question 25

A marker of hepatitis that shows a high degree of infectivity

Answer 25

HBeAg

Question 26

A marker of hepatitis that shows active infection

Answer 26

HBsAg

Question 27

The most specific cells containing antigens that agglutinate with heterophile antibodies

Answer 27

Sheep erythrocytes

Question 28

Serologic test that differentiates Heterophile anti-bodies associated with infectious mononucleosis, serum sickness or Forssman Ag

Answer 28

Davidsohn differential test

Question 29

Largest cell in the peripheral Blood

Answer 29

Monocyte

Question 30

MHC CLASS 1

Answer 30

All nucleated cells CD8 Endogenous Ag structure 3 alpha; 1 beta

Question 31

Antigen in MHC CLASS 3

Answer 31

Benett Goodspeed

Question 32

Gold standard for identification of lymphocyte

Answer 32

Flow Cytometry

Question 33

Enzyme Digestion that cleaves an antibody molecule into 3 pieces = 2 Fab; 1 Fc

Answer 33

Papain; Rodney Porter

Question 34

Enzyme Digestion that cleaves an antibody molecule into 2 pieces = 1 Fab; 1 Fc

Answer 34

Pepsin; Alfred Nisonoff

Question 35

Variable Regions of immunoglobulins are found in what End of each chain

Answer 35

Amino-terminal End

Question 36

Constant region of immunoglobulins are found in what end of each chain

Answer 36

Carboxyl-terminal end

Question 37

a compound that enhances immune response, it is not immunogenic and cannot induce an antibody response

Answer 37

Adjuvant

Question 38

Formerly used as potentiator before PEG

Answer 38

Sendai Virus

Question 39

Medium for Hybridoma technique

Answer 39

Hypoxanthine-Aminopterine-Thymidine

Question 40

The structure formed by the fusion of engulfed materials and enzymatic granules within a phagocytic cell is called a

Answer 40

Phagolysosome

Question 41

IgM

Answer 41

Fixes Complement Has a J Chain Primary response antibody

Question 42

Bence Jones Protein is identical to

Answer 42

L chains

Question 43

soluble antibody combines with soluble antigen

Answer 43

Precipitation

Question 44

Antibody + particulate antigen

Answer 44

Agglutination

Question 45

unit of sedimentation rate of imunoglobulins

Answer 45

Svedberg

Question 46

antigens capable of inducing immune response

Answer 46

immunogens

Question 47

Complement system is inactivated at

Answer 47

56-degree celsius for 30 mins- use within 4 hours

Question 48

complement deficiency that has no known associated dse

Answer 48

C9

Question 49

most common complement deficiency

Answer 49

C2

Question 50

Most severecomplement deficiency

Answer 50

C3

Question 51

preferred method of screening type 1 (hypersensitivty reacton)

Answer 51

in vivo prick test

Question 52

Most immunogenic

Answer 52

Bone Marrow

Question 53

Least immunogenic

Answer 53

Cornea

Question 54

plays an important role as an external defense mechanism?

Answer 54

Phagocytosis

Question 55

Flagellar antigens are designated

Answer 55

H antigen

Question 56

A graft from a mother to her child would be a/an

Answer 56

Allograft

Question 57

A negative test for VDRL but positive for FTA-ABS correlate with

Answer 57

Early syphillis

Question 58

Serologic diagnosis for cryptococcus can be made by testing what specimen/s?

Answer 58

CSF

Question 59

In agglutination, if cells are not centrifuged long enough the results would be

Answer 59

False Negative

Question 60

exact binding type of an antigen

Answer 60

Epitope

Question 61

complement deficiency associated with Hereditary Angiodema

Answer 61

C1INH

Question 62

it measures the total serum IgE

Answer 62

Radioimmunosorbent test (RIST)

Question 63

it measures antigen specific IgE

Answer 63

Radioallergosorbent test (RAST)