Comprehensive Study Guide Flashcards
(274 cards)
Label water the following ions are intra- or extra-cellular:
- K+
- Na+
- Cl-
- proteins
- HCO3-
- ICF
- ECF
- ECF
- ICF
- ECF
Intracellular ions=
K+ & proteins (More negative)
Extracellular ions=
Na+, Cl-, HCO3-
Where do local anesthetics exert their pharmacological action on the nerve?
nerve membrane
How do local anesthetics work?
Specific receptor theory- local anesthetic binds to specific receptors on the Na+ channel
What does the specific receptor theory state?
The local anesthetic binds to a specific receptor on the Na+ channel to prevent the channel from opening (therefore no action potential & no pain)
Which ion channel do local anesthetics bind to?
Specific receptors on the Na+ channel
Speed of conduction of a myelinated nerve:
Speed of conduction of an unmyelinated nerve:
myelinated: 120 m/s
unmyelinated: 1.2 m/s
Where do local anesthetics work at the myelinated nerve?
Local anesthetics work at the nodes of ranvier (abundance of sodium channels here)
In order for local anesthetic to work on a myelinated nerve it needs to block:
2-3 nodes (8-10mm of the nerve)
Drug: Lidocaine
Onset:
Half-Life:
Mg/Kg of max dose:
Onset: 2-3 min
Half-life: 1.6 hrs
(1 hr of pulpal, 3-5 hrs of soft tissue for 2% solution)
Mg/Kg of max dose: 4.4 mg/kg (300mg)
Drug: Prilocaine
Onset:
Half-Life:
Mg/Kg of max dose:
Onset: 2-4 min (slightly slower)
Half-Life: 1.6 hrs
Mg/Kg of max dose:6.0 mg/kg (400mg)
Drug: Mepivacaine
Onset:
Half-Life:
Mg/Kg of max dose:
Onset: 1.5-2 min (rapid!)
Half-Life:1.9 hr
(20-40 min of pulpal. 2-3 hrs of soft tissue anesthesia)
Mg/Kg of max dose: 4.4mg/kg (300 mg)
Bupivacaine:
Onset:
Half-Life:
Mg/Kg of max dose:
Onset: 6-10 min (longer)
Half-Life:2.7 hrs (long!)
Mg/Kg of max dose: 1.3 mg/kg (90 mg)
What drug would be used when more than 90 min of pulpal anesthesia is needed and is also used to reduce post-op pain?
Bupivacaine
Drug: Articaine
Onset:
Half-Life:
Mg/Kg of max dose:
Onset: 1-2 min (rapid!)
Half-Life: 0.5 hrs (short!)
(0.5 hrs of pulpal and 3-5 hrs of soft tissue for 4%)
Mg/Kg of max dose: 7 mg/kg (500 mg)
Drug: Cocaine
Onset:
Half-Life:
Onset: immediate-1 min
Half-Life: 1-1.5 hours
Drug: Procaine
Onset:
Onset: 6-10 min
List the following anesthetics in order of fastest to slowest onset:
-Bupivacaine
-Articaine
-Prilocaine
-Procaine
-Cocaine
-Mepivacaine
-Lidocaine
(Fastest)
1. Cocaine
2. Articaine
3. Mepivacaine
4. Lidocaine
5. Prilocaine
6. Bupivacaine
7. Procaine
(Slowest)
List the following anesthetics in order of longest to shortest duration:
-Bupivacaine
-Articaine
-Prilocaine
-Procaine
-Cocaine
-Mepivacaine
-Lidocaine
(Longest)
1. Bupivacaine
2. Mepivacaine
3. Lidocaine = Prilocaine
4. Cocaine
5. Articaine
For maximum recommended dose (MRD) what guidelines do we follow?
ADA & USPC guidelines (NOT manufacturer)
How does low tissue pH influence local anesthesia?
Low tissue pH (high acidity (H+) is harder to anesthetize (usually associated with inflamed or infected tissues)
How does low anesthetic pH influence local anesthesia?
Low anesthetic pH leads to higher effective shelf life
What is the average pH of local anesthetics?
5.5-7.0