Comprehensive Study Guide Flashcards
(275 cards)
Label whether the following ions are intra- or extra-cellular:
- K+
- Na+
- Cl-
- Proteins
- HCO3-
- ICF
- ECF
- ECF
- ICF
- ECF
Intracellular ions=
K+ and proteins (more negative)
Extracellular ions=
Na+, Cl-, HCO3- (more positive)
Where do local anesthetics exert their pharmacological action on the nerve?
Nerve membrane
How do local anesthetics work?
Specific receptor theory- local anesthetic binds to specific receptor on the Na+ channel
What does the specific receptor theory state?
States that the local anesthetic binds to a specific receptor on the Na+ channel to prevent the channel from opening (therefore no action potential and no pain)
Which ion channel does the local anesthetics bind to ?
specific receptors of the na+ channel
Speed of conduction of a myelinated nerve:
Speed of conduction of an unmyelinated nerve:
myelinated: 120 m/sec
unmyelinated: 1.2 m/sec
Where do local anesthetics work at the myelinated nerve?
local anesthetics work at the nodes of ranvier (an abundance of sodium channels here)
In order for local anesthetic to work on a myelinated nerve, it needs to block:
2-3 nodes (8-10mm of nerve)
Drug: Lidocaine
Onset:
Half-Life:
Mg/Kg of max dose:
onset: 2-3 min
half-life: 1.6 hrs
(1hr of pulpal and 3-5 hrs of soft tissue for 2% solution)
Mg/Kg of max dose: 4.4 mg/kg (300mg)
Drug: Prilocaine
Onset:
Half-Life:
Mg/Kg of max dose:
Drug: Prilocaine
Onset: 2-4 min (slightly slower)
Half-Life: 1.6 hrs
Mg/Kg of max dose: 6 mg/kg (400 mg)
Drug: Mepivacaine
Onset:
Half-Life:
Mg/Kg of max dose:
Drug: Mepivicaine
Onset: 1.5-2 min (rapid!)
Half-Life: 1.9 hrs
(20-40 minutes of pulpal and 2-3 hrs of soft tissue)
Mg/Kg of max dose: 4.4mg/kg
Drug: Bupivacaine
Onset:
Half-Life:
Mg/Kg of max dose:
Drug: Bupivacaine
Onset: 6-10 min (longer)
Half-Life: 2.7 hours (long!)
Mg/Kg of max dose: 1.3 mg/kg (90mg)
What drug would be used when more than 90 minutes of pulpal anesthesia is needed and is also used to reduce post-op pain?
Bupivacaine
Drug: Articaine
Onset:
Half-Life:
Mg/Kg of max dose:
Drug: Articaine
Onset: 1-2 min (rapid)
Half-Life: 0.5 hours (short!!)
(0.5hrs of pulpal and 3-5 hours of soft tissue for 4%)
Mg/Kg of max dose: 7mg/kg (500mg)
Drug: Cocaine
Onset:
Half-life:
Drug: Cocaine
Onset: immediate- 1 min
Half-life: 1-1.5 hrs
What is the onset of Procaine?
6-10 min (a little slower than lidocaine)
List the following anesthetics in order of fastest to slowest onset:
- Bupivacaine
- Articaine
- Prilocaine
- Procaine
- Cocaine
- Mepiivocaine
- Lidocaine
(Fastest)
1. Cocaine
2. Articaine
3. Mepivacaine
4. Lidocaine
5. Prilocaine
6. Bupivacaine
7. Procaine
(Slowest)
List the following anesthetics in order of longest to shortest duration:
- Bupivacaine
- Articaine
- Prilocaine
- Procaine
- Cocaine
- Mepiivocaine
- Lidocaine
(Longest)
1. Bupivacaine
2. Mepivacaine
3. Lidocaine & Prilocaine (equal)
4. Cocaine
5. Articaine
For maximum recommended dose (MRD) what guidelines do we follow?
ADA & USPC guidelines (NOT manufacturer)
How does low tissue pH influence local anesthesia?
Low tissue pH (high acidity/H+) is HARDER to anesthetize (usually associated with inflamed tissues)
How does low anesthetic pH lead influence local anesthesia?
Low anesthetic pH leads to higher effective shelf life
is the average pH of local anesthetics?
5.5-7.0