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Flashcards in Concepts in rheumatology Deck (14):
1

what are the two main categories of arthritis?

Non-inflammatory arthritis (commonly osteoarthritis)

Inflammatory arthritis

2

What can inflammatory arthritis be further subdivided into?

Seropositive (autoantibodies in serum):
-RA
-lupus
-Scleroderma
-Vasculitis
-Sjogrens

Seronegative:
-Ankylosing spondylitis
-Psoriatic arthritis
-Reactive arthritis
-Inflammatory bowel disease arthritis

-infectious

-crystal induced

3

What is the assoc condition with anti-CCP antibody?

-rheumatoid arthritis

4

What are the assoc condition with anti-nuclear antibody?

SLE, Sjogrens syndrome, Systemic sclerosis, MCTD, autoimmune liver disease`

5

What antibodies are found in SLE?

-Anti-dsDNA abody
-Anti-Sm
-Anti-Ro
-Anti-RNP

6

What are the antibodies found in sjogrens syndrome?

-Anti-ro
-Anti-la

7

What antibody is found in limited systemic sclerosis?

-anti-centromere antibody

8

What antibody is found in diffus systemic sclerosis?

-Anti-Scl-70 abody

9

What antibody is found in mixed connective tissue disease?

Anti-RNP antibody and ANA

10

What antibody is found in myositis?

Anti-Jo 1

11

What antibodies are found in anti-phospholipid syndrome?

-anti-cardiolipin antibody
-lupus anti-coagulant

12

What differentials are included with ANCA (anti-neutrophil cytoplasmic antibody)

small vessel vasculitis (GPA, EGPA, MPA)

13

What are the features of inflammatory conditions:
-joint pain/stiffness?
-systemic involvement?
-blood tests?

Joint pain – effect of activity
- Diurnal variation

Morning stiffness (>30mins)

Soft tissue swelling (synovitis)

May have other systems affected

May have inc. : PV/ESR/CRP

PV- plasma viscosity
ESR – erythrocyte sedimentation rate
CRP – c-reactive protein

14

What are the features of non-inflammatory conditions
-joint pain/stiffness
-systemic involvement?
-blood tests?

Mechanical pain – worse with activity
- no diurnal variation

No early morning stiffness

Generally localized
(except fibromyalgia)

No systemic involvement

Normal blood tests