Conditions from severe drug reactions Flashcards
1
Q
What are 3 conditions that can arise due to a severe drug reaction?
A
- Stevens Johnson Syndrome (SJS)
- DRESS
- Toxic Epidermal Necrolysis (TEN)
2
Q
What are Stevens Johnson Syndrome/ Toxic Epidermal Necrolysis?
A
rare, severe reactions secondary to drugs
3
Q
What is the clinical assessment of SJS?
A
- fever
- malaise
- athralgia
- rash
- mouth ulceration
- ulceration of other mucous membranes
4
Q
although TEN & SJS are variants of the same condition, what is the main difference between SJS & TEN?
A
- TEN has more epidermal detachment (30% vs 10% of SJS)
5
Q
what percenatge of epidermal detachment is deemed a SJS/TEN overlap?
A
15-30%
6
Q
what is the treatment for SJS?
A
supportive care
7
Q
what is the clinical assessment of TEN?
A
- often presents with prodromal febrile illness
- ulceration of mucous membranes
- rash ( may be macular, purpuric or blistering)
8
Q
what is treatment for TEN?
A
- identify & stop culprit drug asap
- supprtive therapy
9
Q
What is DRESS?
A
Dermal Reaction with Easinophilia & Systemic Symptoms
10
Q
what is the typical onset for DRESS?
A
2-8weeks after drug exposure
11
Q
what is the clinical assessment of DRESS?
A
- fever
- widespread rash
- easinophilia
- lymphadenopathy
- deranged liver function
12
Q
what is treatment for DRESS?
A
- stop causative drugs
- systemic drugs +/- immuno-suppression
13
Q
what is erythroderma?
A
- Any inflammatory skin disease affecting >90% of skin surface
- can be caused by severe drug reactions
- not a diagnosis, but rather a description
