Congenital/ Circulatory Disorders of the Liver Flashcards
(17 cards)
What are the three genetic disorders regarding liver ?
Crigler-Najjar Syndrome: absent UGT and un-conjugated bilirubin.
Gilbert Syndrome: mutated UGT and unconjugated bilirubin.
Dubin- Johnson Syndrome: mutations in MRP2/ABCC2 gene causing defective bile transport into bile canaliculi –> conjugated bilirubin.
What is chronic liver congestion?
It is when there is an increase in peripheral venous circulation that causes decreased liver outflow
What is liver infarction?
acute occlusion of hepatic artery
What is a zahn infarct?
It is when there is acute occlusion of portal vein along with increased
What are the causes of viral hepatitis?
They are viral causes, metabolic causes, toxins, or vascular tissue.
What are signs/sx of hepatitis?
abdominal pain, dark urine, jaundice, weight loss, fatigue, NV, fatigue
In virus infection, what happens in ALT, AST
They are both very elevated, ALT>AST. bilirubin may be also elevated.
Describe Hepatitis A:
- RNA virus
- fecal- oral transmission
- has 1 month incubation period, self limiting and No chronic form.
- Labs: occurs world wide and common in travelers, (fecal-oral transmission).
- tx is suportive mostly. Vaccination is the key
What is Hepatitis B:
it is commonly transmitted by vertical transmission or blood. Acute form is subclinical but 30% get reallysick.
Hepatitis B (DNA Virus)
vertical transmission or blood,. Acute form is subclinical but 30% get really sick.
What are the viral antigens involved in Hepatitis A:
Acute infection there is surface antigen, and core IgM antibody.
Resolved acute infection= surface antibody and core IgG antibody
Chronic antigen: surface antigen and core IgG antibody
Labs for Hep. B is that
core antigen doesn’t appear in blood
Hepatitis C virus
RNA virus
What does Hep. C virus transform into?
chronic infection
What is hospitalization indication for Hepatitis B
unable to tolerate PO fluids, evidence o liver dysfunction
Hospitalization indications: unable to tolerate PO fluids + evidence of liver dysfunction.
What is the Hepatitis C screening?
Anti-HCV ab –> HCV viral load test ( negative resolved, + chronic)
(- : resolved infection) ( + chronic infection)
If chronic, then fibrosis and US for cirrhosis and cancer)
Hep D and E are i —
india
