Connective tissue Flashcards
(16 cards)
main proteins in ECM
cell adhesion proteins
proteoglycans
cell adhesion proteins
acts as connective tissue glue
proteoglycans
protein core macromolecules for GAG attachment
- increases ECM viscosity
collagen
- cells for formation
- composition
- types
formed by fibroblasts
formed of 3 amino acid chains
- vit. C required for arrangement (scurvy)
in ECM triple helix collagen is modified to tropocollagen to assemble fibrils
collagen I, II, III
collagen I
found in ligaments and tendons
collagen II
found in cartilage
collagen III
reticular fibres component
loose connective tissues
areolar
adipose
reticular - spleen/lymph nodes
dense connective tissues
regular elastic - vocal chords
irregular elastic - vessels
regular collagen (I) - tendons/ligaments
irregular collagen (I and III) - skin
scurvy
lack of vit C
- cannot properly form collagen fibres
- results in opening of wounds and bursting of vessels
marfans syndrome
defective elastic fibres due to abnormal fibrilin-1 production
- weaker fibre attachment
pulmonary emphysema
defective elastic fibres due to increased elastase activity
- results in alveolar and bronchiole collapse
fluid connective tissue
blood/lymph
leukaemia
high levels of immature/abnormal white blood cells (cancerous maybe)
lymphoma
abnormal lymphocytes
myeloma
abnormal plasma cells
