Connective Tissue Flashcards
(32 cards)
Connective tissue
3
- Originates from mesoderm
- Struct support, medium for exchange
- Defense protect fat storage
C.T extracellular matrix
(2 components)
Ground substance
Fibres
2 main type of fibres
Collagen, Elastin
Collagen features
3
- Structural
- Inelastic
- Triple twisted Tropocollagen alpha molecules
Ground substance
Fluid portion w/ glucoaminoglycans, proteoglycan, adhesive glycoproteins
4 categories of collagen types
Fibril forming collagen
Fibril assoc. collagen
Network forming collagen
Transmembrane collagen
Mesenchyme cells
Mesoderm cells
Multipotent then migrate
Fibril forming collagen
3
- Makes fibers for collagen
- Flexible strong fibers, white Tendons, ligaments (Tropocollagen)
- type: I II III V XI
Fibril assoc. collagen
3
- Stabilize collagen
- Molecular bridges, collagen to ground substance
- type: XII IX
Network forming collagen
3
- Formed by epithelial cells (prod by mesenchyme)
- using procollagen & Tropocollagen to form bridge
- type: IV VII
Transmembrane collagen
3
- collagen like protein
- hemidesmosomes
- type: XVII [epidermis to dermis]
Elastin fibers
2
- Elastic protein, and surrounded by myofibrils, fibers arranged in parallel bundles (collagen)
- Wavy, can be stretched and relaxed
Fixed cells (definition)
Resident population within connective tissue, dont migrate, long lived
6 categories of fixed cells
Myofibroblast, pericytes, adipose cell, mast cell, macrophages, transient
Myofibroblast (definition)
Fibroblast w/ contractile properties (actin, myosin) look like smooth muscle cells & function in wound healing in peridontal ligament
6 categories of fixed cells
Myofibroblast, pericytes, adipose cell, mast cell, macrophages, transient
Myofibroblast (definition)
Fibroblast w/ contractile properties (actin, myosin) look like smooth muscle cells & function in wound healing in peridontal ligament
6 categories of fixed cells
Myofibroblast, pericytes, adipose cell, mast cell, macrophages, transient
Myofibroblast (definition)
Fibroblast w/ contractile properties (actin, myosin) look like smooth muscle cells & function in wound healing in peridontal ligament
Pericytes (definition)
Peri-vascular cell,supportive role around blood vessels
Adipose cell (definition)
Fat cell have intracellular glob of fat
Mast cell
Largest of fixed cells and large cytoplasmic granules (heparin, histamine)
Macrophages (definition)
Fixed or transient, remove cellular debris & protect against invators
Dev. from bone bone marrow and move in C.T
Kupffer cells
Macrophage
Liver
