Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

MSK > connective tissue disease -rheumatology > Flashcards

connective tissue disease -rheumatology Flashcards

(79 cards)

Start Studying
1
Q

what is SLE?

A

chronic autoimmune disease mainly involving skin, joints, kidneys, white blood cells and nervous system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

who gets lupus?

A

more common in woman and black people

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q 
fever
weight loss
fatigue
swan neck fingers
poor appetite
malaise
A

SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

muco-cutaneous things of SLE?

A

malar rash, photosensitivity, discoid lupus, oral/nasal ulcer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

msk things for SLE?

A

myalgia
arthralgia
inflam arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

resp thing for SLE?

A

pleural effusion
pleurisy

PE
pulmonary hypertension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

haem things for lupus?

A

anaemia
leukopenia
thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

neuro things for lupus/

A

seizures, headaches, depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

heart things for SLE?

A

pericarditis

ischaemic heart disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

are complement levels high or low in active lupus?

A

LOW

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How do you manage the skin and joint damage in SLE?

A

DMARDs( hydroxychloroquine)
topical steroids
NSAIDS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what must you do in suspected lupus and why?

A

urinalysis to check for bloods on urine to check for renal involvement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is Sjogrens syndrome?

A

autoimmune condition characterized by lymphocytic infiltrates in exocrine glands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

dry eyes
dry mouth
dry vagina

A

Sjogrens syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

increased risk if lymphoma

A

sjogrens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

positive ant-Ro and anti-LA and schirmers test

A

sjogrens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

treatment for Sjorgens

A

saliva replacement
lubricating eye drops
hydroxychloroquine can help with joint pain and fatigue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what causes systemic sclerosis?

A

excessive collagen deposition

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what can systemic sclerosis be divided into?

A

limited and diffuse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

what is the difference between limited and diffuse sclerosis?

A

limited- tends to be confined to face, hands, forearms and feet

diffuse-changes devlop more rapidly and trunk is involved. early organ involvement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

positive anti-centromere antibody and anti SCL-70

A

systemic sclerosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

management for systemic sclerosis?

A

digital ulcer/Raynauds- iloprost, calcium channel blockers

renal involvement-ACEi

GI involvement-proton pump inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

how do manage mixed connective tissue disease?

A

treat the problem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

what is anti-phospolipid syndrome?

A

a disorder where there is recurrent venous/arterial thrombosis and/or fetal loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
who is usually affected by anti-phospolipid syndrome?
young women
26
livedo reticularis
anti-phospolipid syndrome
27
management of anti-phospolipid syndrome?
life long anti-coagulation (low weight heparin if pregnant)
28
what is gout?
deposition of urate crystals within a joint
29
who is more likely to get gout?
males
30
what causes gout/
high serum uric acid levels- caused by too much alcohol, red meat and seafood and being on diuretics
31
deposition of crystals in a joint is triggered by what?
trauma surgery dehydration
32
what body part is mainly affected in joint?
big toe (first metatarsophalangeal joint)
33
can gout mimic septic arthritis?
yes
34
symptoms of gout?
``` intense pain red hot swollen can happen overnight very sudden onset ```
35
what is gouty tophi?
painless white accumulations of uric acid which can occur in soft tissue and can erupt through skin
36
crystals changing from yellow to blue
gout
37
prophylaxis for gout?
allopurinol | febuxostat
38
acute treatment for gout
NAIDS colchicine analgesics steroids
39
what is pseudogout?
deposition of calcium phyrophosphate crystals in joint
40
what is pseudogout associated with?
OA
41
treatment for acute attack pseudogout/
NSAIDS corticosteroids occasionally colchicine
42
Milwaukee shoulder
hydroxyapatite
43
what is hydroxyapatite?
hydroxyapatite crystal deposition in joint. very rapid deterioration
44
treatment for hydroxyapatite?
NSAIDS | steroid injection
45
what is this? ``` it is often misdiagnosed as polymyositis patients tend to be>50 more common in men insidious onset distal muscle weakness weak wrist, finger flexors quads and anterior tibial CK levels lower than polymyositis ```
inclusion body myositis
46
inclusion bodies on muscle biopsy?
inclusion body myositis
47
what is polymalgia Rheumatica?
chronic inflammatory condition of unknown cause. | proximal myalgia of hip and shoulder girdles
48
headache tender jaw claudication visual loss
temporal/giant cell arteritis
49
what is polymyalgia rheumatica associated with>
temporal/giant cell arteritis
50
tests for polymyalgia rheumatica ?
CRP/ESR/PV temporal artery biospy
51
treatment for polymyalgia rheumatica
prednisolone 15mg daily (can use this a diagnostic tool as symptoms respond very fast!)
52
what is polymyositis?
inflammatory myopathy that causes symmetrical, proximal weakness
53
is there an increased malignancy risk with polymyositis?
yes
54
symmeterical, proximal muscle weakness in upper and lower extremities ``` insidious onset worsening over months difficulty with certain activities myalgia dysphagia may have diabetes or thyroid disease might be on steroids/statins alcohol/illicit drug abuser ```
polymyositis
55
definitive test for polymyositis?
muscle biopsy
56
management for polymyositis?
prednisolone 40mg and maybe methotrexate
57
what is dermatomyositis?
same as polymyositis but there is skin involvement e.f rashes
58
``` Grotten's sign (red joints in hand) Heliotrope rash (red circle around eye) ```
dermatomyositis
59
common cancers associated with dermatomyositis?
``` breast lung colon oesophagus bladder ```
60
what is fibromyalgia?
widespread muscle pain and fatigue
61
is there inflammation in fibromayalgia?
no
62
associated with IBS, depression and migraine?
Fibromyalgia
63
what is this? ``` persistent widespread pain and tenderness worse on exertion fatigue disrupted /shitty sleep pins and needles cognitive difficulties anxiety/depression ```
fibromyalgia
64
management for fibromyalgia?
graded exercise programme | antypical analgesia
65
what is vasculitis?
inflammation of blood vessels
66
2 main causes of large vessel vasculitis?
``` temporal (giant cell) arteritis Takayasu arteritis (TA) ```
67
who does TA mostly affect?
young women in 20's/30's
68
when might you hear carotid bruits?
giant cell arteritis
69
how to treat large vessel vasculitis?
prednisolone 40-60mg | methotrexate nay be added
70
features of small and medium vasculitis?
``` fever weight loss a raised , non blanching purpuric rash arthralgia/arthritis lung opacities on x ray ```
71
which type of small/medium vessel vasculitis involves this? ENT symptoms- nose bleeds, deafness, recurrent sinusitis and nasal crusting
Granulomatosis with polyangitis (GPA)/ Wegeners
72
associated with cANCA and PR3
Granulomatosis with polyangitis (GPA)/ Wegeners
73
which type of small/medium vessel vasculitis involves this? late onset asthma , rhinitis and raised eosinophil count and some neurological symptoms
Eosinophilic Granulomatosis with polyangitis (EGPA)
74
most important complication of microscopic polyangiitis?
glomerulonephritis
75
necrotizing vasculitis
microscopic polyangiitis
76
management for microscopic polyangiitis?
Iv steroids and cyclophosphamide
77
what is Henoch-Schonlein purpura?
IgA mediated disorder
78
who is commonly affected by Henoch-Schonlein purpura
children
79
what type of small/medium vessel vasculitis is this? ``` purpuric rash over buttocks and lower limb a history of upper resp tract infection abdominal pain bloody diarrhoea vomiting joint pain without swelling ```
Henoch-Schonlein purpura

MSK (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions