Connective Tissue Diseases

Question 1

CT are any biological tissues with an extensive matrix that do what 3 things?

Answer 1

1. provide structure, support and defense
2. transport material
3. bind organs together

Question 2

CT consists of what 2 things?

Answer 2

1. cell fibers

2. ground substance

Question 3

Cell fibers consist of?

Answer 3

1. collagen

2. elastin

Question 4

What 3 things make up ground substance?

Answer 4

1. water
2. fluid
3. protein

Question 5

6 types of CT?

Answer 5

1. loose tissue
2. fibrous tissue
3. adipose tissue
4. blood
5. cartilage
6. bone

Question 6

Loose tissue is composed of _____ and _____.

Answer 6

collagen; elastin

Question 7

2 examples of loose tissue?

Answer 7

1. blood vessels

2. internal organs

Question 8

_____ tissue = mostly collagen, few elastin

Answer 8

fibrous

Question 9

2 examples of fibrous tissue?

Answer 9

1. tendons

2. ligaments

Question 10

Many T diseases feature abnormal _____ system activity.

Answer 10

immune

Question 11

Is the cause of CT diseases known?

Answer 11

No

Question 12

3 potential causes of autoimmune diseases?

Answer 12

1. genes
2. environment
3. behavious

Question 13

___-___% of SLE pt’s have 1st or 2nd degree relative with SLE

Answer 13

10-12

Question 14

3 diseases in family of CT diseases that overlap and cause mixed CT disorder?

Answer 14

1. systemic lupus erthematosus
2. scleroderma
3. polymyositis/dermatomyositis

Question 15

SLE = a _____-_____ disease

Answer 15

multi-system

Question 16

9 body systems affected in SLE?

Answer 16

1. skin
2. lungs
3. kidney
4. CNS
5. circulatory system
6. heart
7. GI system
8. muscle and joints
9. oral and nasal ulcers

Question 17

Highest at risk of SLE?

Answer 17

women during reproductive years

Question 18

SLE female:male ratio?

Answer 18

9:1

Question 19

11 criteria for SLE classification?

Answer 19

1. malar rash
2. discoid rash
3. photosensitivity
4. oral ulcers
5. non-erosive arthritis
6. pleurites or pericarditis
7. renal disorder
8. neurological disorder
9. hematologic disorder
10. immunologic disorder
11. • antinuclear antibody test

Question 20

5 features of non-erosive arthritis?

Answer 20

1. transient
2. symmetrical
3. affecting small joints
4. less severe than RA
5. when arthritis is present, 5-40 % of pt’s develop a non-erosive arthropathy due to ligamentous laxity and muscle contracture

Question 21

8 clinical features of SLE neurologic disorder?

Answer 21

1. seizures
2. psychosis
3. behaviour/personality changes, depression
4. cognitive dysfunction
5. stroke
6. peripheral neuropathy
7. chorea
8. transverse myelitis

Question 22

Up to ___% of pt’s with SLE develop lupus nephritis

Answer 22

50

Question 23

__% of pt’s with SLE require kidney dialysis or transplant

Answer 23

10

Question 24

Renal clinical features of SLE usually (symptomatic/asymptomatic)

Answer 24

asymptomatic

Question 25

Hallmark clinical finding in regard to renal aspect of SLE?

Answer 25

proteinuria

Question 26

_____ clinical features of SLE most frequent cause of disease-related death

Answer 26

renal

Question 27

___-___% of pt's w/ SLE will experience the GI clinical features of SLE.

Answer 27

15-75

Question 28

6 clinical features of GI aspect of SLE?

Answer 28

1. oral ulcers 2. nausea 3. vomiting 4. pancreatitis 5. hepatitis 6. mesenteric vasculitis

Question 29

4 other symptoms experienced with SLE?

Answer 29

1. pain (fibromyalgia) 2. severe fatigue 3. memory loss 4. depression

Question 30

3 aspects of PT management of pt's with SLE?

Answer 30

1. pain management 2. therapeutic exercise and PA 3. pt education

Question 31

3 things to educate pt's with SLE on?

Answer 31

1. energy conservation principles 2. joint protection principles 3. sun protection

Question 32

Exercise has ___ adverse effect on SLE disease activity

Answer 32

no

Question 33

Exercise can lead to (more/less) fatigue in pt's with SLE.

Answer 33

less

Question 34

Exercise has a _____ effect on CR capacity in pt's with SLE.

Answer 34

positive

Question 35

4 p's of energy conservation principles?

Answer 35

1. prioritize 2. plan 3. pace 4. posture

Question 36

8 joint protection principles?

Answer 36

1. respect for pain 2. balance activity and rest 3. avoid repetitive activities 4. use large, stronger joints for activities 5. avoid staying in 1 position for a prolonged period of time 6. maintain use of joints in good alignment 7. maintain healthy body weight 8. maintain good posture during daily activities

Question 37

Exercise and PA are safe and effective treatments for people with SLE (T/F).

Answer 37

TRUE

Question 38

3 main non-pharmalogic interventions in the management of CT disease, such as SLE?

Answer 38

1. pain control 2. PA 3. pt education