Constant Rate Regimen Flashcards
(17 cards)
What does the term “constant-rate regimen” signify?
The drug is administered at a constant or zero-order rate.
How can a constant plasma concentration be best accomplished?
By infusing the drug at a constant rate.
Examples
* IV infusion via infusion pump
* Orally administered drugs: slow-release tablets
* Transdermal patches
What is Ro?
The infusion rate
What is k x A?
The rate of elimination
What does Cp mean?
plasma concentration
What is the steady-state concentration?
The point where Cp becomes constant, indicating a balance between drug infusion and elimination.
What is the tss?
The time required to reach at least 95% of the Css, typically after 4-5 half lives.
What is the infusion phase?
The period during which the drug is continuously administered.
What is the post-infusion phase?
The period after infusion stops, where drug elimination occurs.
Css=
Ro/CL
Ro=
k x Ass
What is Ass?
The drug amount in the body at steady state
Ass=
Ro/k
C=
Css(1-e^-kt)
What are the benefits of combining IV infusion with an IV bolus?
- Combining IV infusion with an IV bulis loading dose can maintain Cp near Css from the beginning of drug administration.
Ccombined=
Cinfusion + Cbolus
Ro=
Css x CL
