Contraindications Flashcards

Question

Antimuscarinics - GU uses | oxybutynin, tolterodine, solifenacin

Answer 1

``` ⚠️ Angle-closure glaucoma ⚠️ Arrhythmias ⚠️ Urinary retention ⚠️ Elderly ⚠️ Dementia ``` ❌ Urinary tract infection 💊 Tricyclic antidepressants

Answer 2

⚠️ Elderly ⚠️ Dementia ⚠️ Parkinson's 💊 Drugs that prolong the QT interval

Answer 3

⚠️ Cardiovascular diseases ❌ Severe heart disease ❌ Neutropenia 💊 Dopamine-blocking antiemetics 💊 Drugs that prolong the QT interval

Answer 4

⚠️ Pregnant women ⚠️ Breastfeeding ⚠️ Severe renal impairment

Answer 5

⚠️ Elective surgery ⚠️ Renal and hepatic impairment ❌ Active bleeding 💊 CYP inhibitors and inducers 💊 Antiplatelet drugs 💊 Anticoagulants 💊 NSAIDs

Answer 6

⚠️ Peptic ulceration ⚠️ Gout ❌ Children under 16 ❌ Aspirin hypersensitivity ❌ Third trimester of pregnancy 💊 Antiplatelet drugs 💊 Anticoagulants

Answer 7

⚠️ Reduced TPMT activity ⚠️ Renal impairment ⚠️ Hepatic impairment ⚠️ Pregnancy ❌ Absent TPMT activity 💊 Allopurinol 💊 Trimethoprim 💊 Warfarin

Answer 8

⚠️ Heart failure ⚠️ Haemodynamic instability ⚠️ Hepatic failure ❌ Asthma ❌ Heart block ❌ Verapamil ❌ Diltiazem

Answer 9

⚠️ Cardiovascular disease

Answer 10

⚠️ Elderly ⚠️ Respiratory impairment ⚠️ Neuromuscular disease ⚠️ Liver failure 💊 CYP inhibitors 💊 Amiodarone 💊 Fluconazole

Answer 11

⚠️ Smokers ⚠️ Dental disease ❌ Severe renal impairment ❌ Hypocalcaemia ❌ Upper GI disorders 💊 Calcium salts 💊 Antacids

Answer 12

❌ Hypercalcaemia 💊 Sodium bicarbonate

Answer 13

⚠️ Poor left ventricular function ⚠️ AV nodal conduction delay ❌ Unstable angina ❌ Severe aortic stenosis ❌ Beta-blockers

Answer 14

⚠️ Pregnancy ⚠️ Hepatic disease ⚠️ Renal disease ⚠️ Cardiac disease ❌ Antiepileptic hypersensitivity syndrome ``` 💊 Warfarin 💊 Oestrogens 💊 Progestogens 💊 Macrolides 💊 Antipsychotics 💊 Tramadol ```

Answer 15

⚠️ At risk of C. difficile infection ⚠️ Epilepsy ⚠️ Renal impairment ❌ Allergy ❌ Anaphylactic reaction 💊 Valproate

Answer 16

⚠️ Hepatic impairment ``` ❌ Hypersensitivity reactions ❌ Bone marrow disorders ❌ Third trimester of pregnancy ❌ Breastfeeding ❌ Children <2 years ```

Answer 17

⚠️ History of pneumonia | ⚠️ Children

Answer 18

⚠️ Infection ⚠️ Children ``` 💊 NSAIDs 💊 B2-agonists Theophylline 💊 Loop or thiazide diuretics 💊 Phenytoin 💊 Carbamazepine 💊 Rifampicin ```

Answer 19

⚠️ Infection | ⚠️ Facial lesions

Answer 20

⚠️ Renal failure ⚠️ Hypokalaemia ⚠️ Hypomagnesaemia ⚠️ Hypercalcaemia ❌ Second-degree heart block ❌ Intermittent complete heart block ❌ Ventricular arrhythmias

Answer 21

⚠️ Elderly (>80) ⚠️ History of pancreatitis ⚠️ Moderate-to-severe renal impairment ❌ Hypersensitivity ❌ T1DM ❌ Ketoacidosis 💊 Other anti-diabetics increase risk of hypoglycaemia 💊 Prednisolone 💊 Thiazide 💊 Loop diuretics

Answer 22

⚠️ Hepatic disease ⚠️ Renal disease ``` ❌ Active, clinically significant bleeding ❌ Risk factors for major bleeding ❌ Pregnancy ❌ Breastfeeding ❌ Rifampicin ❌ Phenytoin ``` 💊 Other antithrombotic agents increase risk of bleeding 💊 Macrolides 💊 Protease inhibitors 💊 Fluconazole

Answer 23

⚠️ Hepatic encephalopathy ⚠️ Hypokalaemia ⚠️ Hyponatraemia ⚠️ Gout ❌ Hypovolaemia ❌ Dehydration 💊 Lithium 💊 Digoxin 💊 Aminoglycosides

Answer 24

⚠️ Hyponatraemia ⚠️ Gout ❌ Hypokalaemia 💊 Loop diuretics

Answer 25

⚠️ Elderly ⚠️ Cognitive or psychiatric disease ⚠️ Cardiovascular disease 💊 First-generation antipsychotics 💊 Metoclopramide

Answer 26

❌ Bleeding ❌ Intracranial haemorrhage ❌ Previous streptokinase treatment 💊 Anticoagulants and antiplatelets increase risk of haemorrhage

Answer 27

⚠️ Renal impairment 💊 Sedating drugs

Answer 28

``` ⚠️ Clotting disorders ⚠️ Severe uncontrolled hypertension ⚠️ Recent surgery or trauma ⚠️ Invasive procedures ⚠️ Renal impairment ```

Answer 29

⚠️ Renal impairment

Answer 30

⚠️ Intestinal disease ⚠️ Atopic predisposition 💊 Can reduce absorption of levothyroxine and bisphosphonates

Answer 31

⚠️ Hypersensitivity to other antiepileptic drugs ⚠️ Hepatic impairment ``` 💊 Carbamazepine 💊 Phenytoin 💊 Oestrogens 💊 Rifampicin 💊 Protease inhibitors 💊 Valproate ```

Answer 32

⚠️ Heart failure ⚠️ Ascites ⚠️ Electrolyte disturbances ❌ Intestinal obstruction

Answer 33

⚠️ Haemorrhoids ⚠️ Anal fissures ❌ Intestinal obstruction

Answer 34

⚠️ Asthma

Answer 35

⚠️ Renal impairment

Answer 36

⚠️ Reduced cardiac output

Answer 37

⚠️ Severe hepatic impairment ⚠️ Severe renal impairment ❌ Macrolide hypersensitivity ``` 💊 Warfarin 💊 Statins 💊 Amiodarone 💊 Antipsychotics 💊 Quinine 💊 Quinolone antibiotics 💊 SSRIs ```

Answer 38

⚠️ Renal impairment ⚠️ Hepatic impairment ⚠️ Acute alcohol intoxication ⚠️ Chronic alcohol abuse ❌ Severe tissue hypoxia ❌ Acute kidney injury 💊 IV contrast media

Answer 39

⚠️ Abnormal liver function ❌ Pregnancy ❌ Severe renal impairment 💊 NSAIDs 💊 Penicillins 💊 Trimethoprim 💊 Clozapine

Answer 40

⚠️ Severe liver disease ❌ Alcohol 💊 Warfarin

Answer 41

⚠️ Opioid dependence | ⚠️ Palliative care

Answer 42

❌ Severe aortic stenosis ❌ Haemodynamic instability ❌ Hypotension ❌ Phosphodiesterase inhibitors

Answer 43

❌ Pregnant women towards term ❌ Babies in the first 3 months of life ❌ Renal impairment

Answer 44

⚠️ Peptic ulcer disease ⚠️ GI bleeding ⚠️ Cardiovascular disease ⚠️ Renal impairment ❌ Severe renal impairment ❌ Heart failure ❌ Liver failure ``` 💊 Aspirin 💊 Corticosteroids 💊 Anticoagulants 💊 SSRIs 💊 ACE inhibitors 💊 Diuretics ```

Answer 45

⚠️ Family history of VTE ⚠️ Cardiovascular disease ❌ Personal history of VTE ❌ Breast cancer ❌ Known thrombogenic mutation 💊 Rifampicin 💊 Carabamazepine 💊 Lamotrigine

Answer 46

``` ⚠️ Hepatic failure ⚠️ Renal impairment ⚠️ Elderly ⚠️ Respiratory failure ⚠️ Biliary colic ⚠️ In combi with other sedating drugs ```

Answer 47

``` ⚠️ Significant respiratory disease ⚠️ Renal impairment ⚠️ Hepatic impairment ⚠️ Elderly ⚠️ Other sedating drugs ``` ❌ Uncontrolled epilepsy ``` 💊 Drugs that lower seizure threshold e.g. antipsychotics 💊 Serotonergic drugs 💊 SSRIs 💊 Tricyclic antidepressants 💊 Tramadol ```

Answer 48

⚠️ Chronic excessive alcohol use ⚠️ Malnutrition ⚠️ Low body weight ⚠️ Severe hepatic impairment

Answer 49

⚠️ Renal impairment ❌ Penicillin allergy 💊 Methotrexate

Answer 50

⚠️ C. difficile infection ⚠️ Moderate/severe renal impairment ❌ Penicillin allergy 💊 Methotrexate

Answer 51

⚠️ C. difficile infection ⚠️ Penicillin-associated liver injury ⚠️ Severe renal impairment ❌ Penicillin allergy history

Answer 52

⚠️ C. difficile infection ⚠️ Renal failure ⚠️ Hepatic impairment ❌ Penicillin allergy history ❌ Prior flucloxacillin-related hepatotoxicity 💊 Methotrexate

Answer 53

⚠️ Hepatic impairment ⚠️ Renal impairment ❌ Stroke ❌ Acute coronary syndrome ❌ Cardiovascular disease ``` 💊 Nitrates 💊 Nicorandil 💊 Vasodilators 💊 Amiodarone 💊 Diltiazem 💊 Fluconazole ```

Answer 54

⚠️ Aphakia/pseudoaphakia | ⚠️ Iritis, uveitis or macular oedema

Answer 55

⚠️ Osteoporosis 💊 Clopidogrel

Answer 56

⚠️ Hearing or visual loss ⚠️ First trimester of pregnancy ⚠️ Glucose-6-phosphate dehydrogenase deficiency 💊 Drugs that prolong the QT interval (amiodarone, antipsychotics, quinolones, macrolides, SSRIs)

Answer 57

⚠️ Seizures ⚠️ Children ⚠️ QT prolongation 💊 Theophylline 💊 NSAIDs 💊 Prednisolone 💊 Drugs that prolong the QT interval (amiodarone, antipsychotics, quinine, macrolides, SSRIs)

Answer 58

``` ❌ Coronary artery disease ❌ Cerebrovascular disease ❌ Hemiplegic migraines ❌ Basilar migraines ❌ Monoamine oxidase inhibitors (tramadol, SSRIs and tricyclic antidepressants) ```

Answer 59

``` ❌ Pregnancy ❌ Lactation ❌ Pre-menopausal women ❌ Warfarin ❌ Fluoxetine ❌ Paroxetine ```

Answer 60

``` ⚠️ Renal impairment ⚠️ Hepatic impairment ⚠️ Pregnant ⚠️ Breastfeeding ⚠️ Amiodarone ⚠️ Diltiazem ⚠️ Itraconazole ⚠️ Macrolides ⚠️ Amlodipine ```

Answer 61

⚠️ Hepatic impairment ⚠️ Renal impairment ⚠️ Increased risk of hypoglycaemia

Answer 62

⚠️ Children 12 and under ⚠️ Renal impairment ❌ Pregnancy ❌ Breastfeeding

Answer 63

⚠️ Coronary artery disease | ⚠️ Hypopituitarism

Answer 64

``` ⚠️ Folate deficiency ⚠️ Renal impairment ⚠️ Neonates ⚠️ Elderly ⚠️ HIV infection ``` ❌ First trimester of pregnancy

Answer 65

⚠️ Hepatic impairment ⚠️ Severe renal impairment ❌ Women of child-bearing age ❌ Conception ❌ First trimester of pregnancy ``` 💊 Lamotrigine 💊 Warfarin 💊 Carbamazepine 💊 Phenytoin 💊 Macrolides 💊 Protease inhibitors 💊 Antipsychotics 💊 Tramadol ```

Answer 66

⚠️ Renal impairment ⚠️ Elderly 💊 Aminoglycosides 💊 Loop diuretics 💊 Ciclosporin

Answer 67

⚠️ Co-existing vitamin B12 and folate deficiency

Answer 68

⚠️ Liver disease ❌ Immediate risk of haemorrhage ❌ Pregnancy ``` 💊 Phenytoin 💊 Carbamazepine 💊 Rifampicin 💊 Fluconazole 💊 Macrolides ```

Answer 69

⚠️ Elderly ❌ Obstructive sleep apnoea ❌ Respiratory muscle weakness ❌ Respiratory depression 💊 Macrolides 💊 Phenytoin 💊 Rifampicin

Contraindications Flashcards

(93 cards)