Contrast Media in Radiology

Question 1

1st Contrast Agents

Answer 1

Bi(NO3)3
SrBr2
NaILiI

Question 2

Concept of Osmolarity

Answer 2

dissociation behaviour of compounds in solution

Question 3

CT contrast agent

Answer 3

Barium sulfate
Diagnosis purposes: abnormalities of the gastrointestinal tract

Xenon
readily diffusible mono-atomic gas
− low, but not insignificantly soluble in blood
− fairly good solubility in adipose tissue

Question 4

MRI – Contrast Agent

Answer 4

need unpaired electrons in f-orbitals for paramagnetic contrast agent

Question 5

T1 relaxation agent

Answer 5

Gd Contrast Agents->inner sphere solvatation at metal center is very important for effectivenes

Question 6

Nanoparticulate MRI Contrast Agents

Answer 6

Iron Oxide NPs or derivatives (ferrites)
advantages:
 lack of toxicity
 high stability
 biodegradability
 acceptable contrast enhancement

Question 7

T2 contrast agent

Answer 7

Iron Oxide NPs or derivatives -> creation of own magnetic field that disturbs magnetic field provided by the instrument

Question 8

18[F]-Fluorine labelling strategies

Answer 8

prosthetic labeling
true labelling
mimicking