Controlled drug delivery 3 Flashcards
(26 cards)
What controls drug release for responsive DDS?
pH Chemicals Enzymes Ultrasound Magnetism Light
Changes in ionisation or cleavage of functional groups due to altered pH can affect what?
Sol-gel behaviour
What are drug pellets coated in for COLAL colonic drug delivery?
ethylcellulose and ‘glassy’ amylose
What are the pros of implantable devices?
Convenience
Compliance
Control
Commercial
What are the cons of implantable devices?
Surgery Failure Potency Reactions/compatibility Commercial
What can implants be used for in localised terms?
Ocular Dental Contraception Pain Vasculature
What can implants be used for in long term terms?
Contraception Pain management Diabetes Incontinence Systemic infection
Name two examples of diffusion controlled implants for contraception?
Norplant
Jadelle
What is retisert used for?
Chronic noninfectious uveitis
What is I-Vation intravitreal implant used for?
Age related macular degeneration
Diabetic macular edema
Glaucoma
How long does it take to insert a I-Vation intravitreal implant?
15 minutes
How long does a I-Vation intravitreal implant last?
up to 2 years
What part of the eye is the I-Vation intravitreal implant placed in?
Sub-conjunctiva
What is Medidur used for?
Diabetic Macular Edema
What does Medidur do?
Releases a constant amount of drug to the back of the eye for up to 36 months
What is Vitrasert used for?
Intraocular ganciclovir for AIDS-related cytomegalovirus retinitis
Where is Vitrasert inserted?
Posterior of the eye
How long does Vitrasert last?
5 to 8 months
What is Ocusert used for?
Elevated intraocular pressure in pilocarpine responsive glaucoma patients
What do drug eluting stents limit?
Restenosis
What is Viadur used for?
Pain, urinary problems and other symptoms associated with advanced bladder cancer
What is Viadur?
Osmotic pump
What are Gliadel wafers used for?
treatment of high grade malignant gliomas
How long do Gliadel wafers take to erode?
2 to 3 weeks
