Convulsive disorders Flashcards

(44 cards)

1
Q

Epilepsy:

A

occasional sudden excessive rapid and local discharge of gray matter

any disorder characterized by recurrent unprovoked seizures

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2
Q

Where are rates of epilepsy higher?

A

third world countries

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3
Q

Is epilepsy controllable?

A

yes, 60-70% of epileptics have well controlled seizures on current meds

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4
Q

Who has a higher incidence of epilepsy, when does it occur?

A

men, higher incidence at the beginning and end of our lives

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5
Q

What are the types of epilepsy?

A

genetic
structural/metabolic
unknown

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6
Q

What are the causes of genetic epilepsies?

A

inherited in autosomal dominant fashion

channelopathies

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7
Q

What are the causes of structural/metabolic epilepsies?

A
head trauma
tumors
vascular
infectious
degenerative
metabolic disorders
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8
Q

What are the classifications of seizures?

A

focal onset

generalizes onset

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9
Q

What are the subtypes of focal onset?

A

no alteration of consciousness (simple partial)- aura, motor, sensory, autonomic, “psychomotor”

altered consciousness (complex partial)

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10
Q

What are the subtypes of generalized onset?

A
tonic
clonic
atonic
myoclonic
absence
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11
Q

Partial seizures: Onset

A

single focus giving rise to abnormal discharges
symptoms are very specific and can help localize the lesion/source
no loss of consciousness

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12
Q

Simple partial seizure:

A

Twitching
sensory- abnormal sensations, paresthesias, abnormal vision, sounds or smells, distortions of perception
autonomic- flushing, tingling nausea

“march” to different parts of the body

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13
Q

Complex partial seizure:

A

aura- about 50%, which is a warning for the seizure, typically a familiar feeling (deja vu), nausea, heat or tingling, or distortion of sensory perceptions

automatism- lip smaking, picking at clothes, walking around aimlessly or saying nonsense phrases over and over again
staring and black out for a few seconds to minutes

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14
Q

Generalized seizure: Onset

A

start all over the brain at once

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15
Q

Absence seizure:

A
impairment of consciousness
usually in childhood, cease by the 20 yo
starts with staring spells
able to resume activities
onset and termination are abrupt

Typical EEG - 3hz spike and wave

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16
Q

Generalized Tonic-Clonic Seizures (Grand mal)

A

sudden loss of consciousness and tonic activity (stiffening)
followed by clonic activity (rhythmic jerking) of limbs
eyes may roll up
lasts 1-3 min
postictal phase- sluggish, sleepy and confused

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17
Q

Atonic seizures

A

drop attacks
children or adults with wide spread brain injuries
suddenly become limp and may fall to the ground

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18
Q

Myoclonic seizure:

A

brief unsustained jerk or series of jerks

19
Q

Tonic seizures

A

stiffening of muscles as the primary seizure manifestation

consciousness may or may not be lost

20
Q

What is the breakdown of adult seizure types?

A

complex partial- 40%
simple partial- 20%
primary gen tonic clonic- 20%

21
Q

What is the most common seizure in kids?

22
Q

What is the rate of re occurrence after a first unprovoked seizure?

23
Q

What are causes of epilepsy?

A

alteration of seizure threshold, acquired or inherited

specific epileptogenic disturbances- metabolic disturbances, anoxia, trauma, vascular malformation, tumor and infection

24
Q

What is the first aid for a tonic clonic seizure?

A

turn person on side with head inclined toward ground to keep airway open, protect from near hazards
DO NOT PUT RIGID OBJECT IN MOUTH OR RESTRAIN

25
Staticus epilepticus:
a seizure or series of seizures lasting for 30 min w/out return to normal neurological emergency!
26
do anti epileptic drugs work?
yes, 50% seizure free with first drug, 30% though not seizure free even after the third drug
27
What are considered the rescue drugs for seizures?
benzodiazepines
28
What drugs will make primarily generalized seizures worse?
phenytoin, carbamazepine, oxcarbazepine
29
What is a useful tool for diagnosisng and localizing seizures?
EEG monitoring | if its bilateral synchronus = generalized
30
Epilepsy in which part of the brain is extremely refractory to meds?
temporal, need surgery, good success rate
31
What is an alternative to epileptic surgery?
corpus callostomy | vagal nerve stimulation (pacemaker of the brain)- palliative only
32
What are the most common congenital abnormalites from AED therapy?
orofacial clefts, heart defects less common: microcephaly, NTD
33
What is SUDEP? When is it most likely to occur?
sudden unexpected death in epilepsy, higher frequency in males, pts with refractory epilepsy
34
Seizure precautions
no driving no swimming or tub baths w/out someone around avoid climbing heights
35
What is the most common cause of seizures with the onset at age 60 years or older?
vascular disease
36
When does an absence seizure most likely to occur?
in conversation
37
What meds do you give for focal seizures?
carbamazapine, phenytoin or valproic acid
38
What meds do you give for generalized seizures?
valproate
39
Do you give a pregnant woman an antiepileptic?
According to book: even though antiepileptics are tetratogenic you still give it to a pregnant woman
40
What is the most common cause of lower concentration of drug than expected for the prescribed dose?
poor patient compliance
41
What type of seizure is a/w alcohol with drawl?
tonic clonic, give benzo
42
most common cause of status epilepticus
poor compliance
43
Tx of status epilepticus:
50% dextrose IV IV bolus lorazepam, diazapam if it doesnt work if the continue, phenobarbital
44
Which seizures are gradual in onset and termination?
atypical absence, marked changes in tone occur