core drugs

Question 1

name a beta agonist

Answer 1

salbutamol

Question 1

name beta blockers

Answer 1

atenolol
bisoprolol
propanolol
pindolol

Question 2

what is salbutamol used for

Answer 2

asthma

Question 3

MOA of salbutamol

Answer 3

activates B2 adrenreceptor causing bronchodilation

Question 4

what is atenolol used for

Answer 4

high BP, angina, post MI

Question 5

MOA of atenolol

Answer 5

selective B1 adrenreceptor blocker
dec HR -> dec BP

Question 6

what is bisoprolol used for

Answer 6

high BP, heart failure, angina

Question 7

MOA of bisoprolol

Answer 7

selective B1 adrenreceptor blocker
dec HR -> dec BP

Question 8

what is propanolol used for

Answer 8

high BP, angina, arrhythmia

Question 9

propanolol MOA

Answer 9

non- selective B1 and B2 adrenreceptor blockers

Question 10

what is pindolol used for

Answer 10

high BP, angina, arrhythmia

Question 11

pindolol MOA

Answer 11

non- selective B1 and B2 adrenreceptor blockers

Question 12

chronotropic meaning

Answer 12

heart rate

Question 13

inotropic meaning

Answer 13

contraction force

Question 14

name COX inhibitors

Answer 14

aspirin
ibuprofen
paracetamol

Question 15

what is aspirin used for

Answer 15

pain relief, prevent MI or strokes

Question 16

what is ibuprofen used for

Answer 16

pain relief and inflammation relief

Question 17

what is paracetamol used for

Answer 17

pain relief and fever reduction

Question 18

aspirin MOA

Answer 18

inhibits COX 1 and COX 2
reduced production of prosglandins
reduced pain

Question 19

ibuprofen MOA

Answer 19

inhibits COX 1 and COX 2
reduced production of prosglandins
reduced pain

Question 20

paracetamol MOA

Answer 20

inhibits mostly COX 2 (in brain)

Question 21

name SERT antagonists

Answer 21

SSRIs
amitriptyline

Question 22

what are SSRIs used for

Answer 22

depression

Question 23

what is amitriptyline used for

Answer 23

depression

Question 24

SSRIs MOA

Answer 24

inhibits SERT, inc. serotonin at synapse inc. serotonin signalling at post-synaptic cleft alleviates symptoms of depression

Question 25

amitriptyline MOA

Answer 25

inhibits SERT and NET, inc. serotonin and NA at synapse inc. serotonin and NA signalling at post-synaptic cleft alleviates symptoms of depression

Question 26

name some other core drugs

Answer 26

amlodipine thiazides theophylline insulin sodium valporate codeine

Question 27

amlodipine use

Answer 27

angina and high BP

Question 28

thiazides use

Answer 28

edema and high BP

Question 29

theophylline use

Answer 29

COPD

Question 30

insulin use

Answer 30

diabetes

Question 31

sodium valproate use

Answer 31

epilepsy and bipolar

Question 32

codeine use

Answer 32

pain relief and cough supression

Question 33

amlodipine MOA

Answer 33

calcium channel blocker, dec BP

Question 34

thiazides MOA

Answer 34

blocks Na-Cl symporter, causing inc of NaCl & water secretion, dec BP

Question 35

theophylline MOA

Answer 35

inhibits phosphodiesterase, inc. in cAMP, causing bronchodilation

Question 36

insulin MOA

Answer 36

agonist at insulin receptor

Question 37

sodium valproate MOA

Answer 37

multi-targetted - inhibits Na channels - enhances GABAergic transmission - inhibits T-type Ca channels

Question 38

codeine MOA

Answer 38

metabolised in the liver to form morphine by enzyme CYP206 binds to oploid receptors