Corneal Diseases Flashcards

(56 cards)

1
Q

Chronic corneal diseases

A
Congenital 
Dystrophy
Ectasia 
Degeneration 
Dry eye 
Surgery
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2
Q

MICROCORNEA

A

corneal diameter less than 10mm
uni/bilateral
the eye can be normal- or have other stuff. e.g. cataract

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3
Q

MEGALOCORNEA

A

cornea bigger than 13mm
symmetrical
non progressive
DD- Congenital glaucoma

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4
Q

Congenital CORNEAL PROBELMS

A

microcornea
megalocornea
Posterior embryotoxon
Sclerocornea

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5
Q

POSTERIOR EMBRYOTOXON

A

Prominent irregular ridge which lies cereal to the limbus
caused by anterior placed schwalbes ring
can be seen with gonioscopy- in about 30% of population

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6
Q

SCLEROCORNEA

A

limbus is not defined
90%BILATERAL
non-progressive
central cornea is usually normal

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7
Q

Types of dystrophy-

DYSTROPHY

A

Primary bilateral inherited disorders.- they have distinct clinical pathological findings. -stationary/slow progression, occurs in the absence of inflammation

Epithelial- Dot-Map-FIngerprints/Meesmans
Stromal-Granular/Lattice/Macular
Endothelial-CHED/Fuchs

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8
Q

MAP-DOt fingerprint

A

Dots- microcyts …..
Map-Geogrophic opacities c v d
Fingerprint-subepithelial ridges&raquo_space; «< LL&raquo_space; // \ LL

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9
Q

MEESMANS dystrophy

A

Dominant
FB sensation
mild vision reduction
small grey-white punctuate opacities

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10
Q

VORTEX dystrophy

A

Corneal deposits distributed in the Whorls like pattern
look for - Amiodarone intake
- Indomathacin intake
- Fabry’s disease

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11
Q

GRANULAR DYSTROPHY

snowflakes

A

Axial, greyish opaque granules
vision good until middle age- when it gets bigger- va reduces
minimal symptoms
BILATERAL- no inflammatory

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12
Q

LATTICE DYSTROPHY

A

greyish, linear, branching oacities- central cornea

severe recurrent erosions- early reduction in vision

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13
Q

macular dystrpohy

A

LEAST COMMON-
greyish opaque spots- indistinct borders affecting entire cornea
reduced VA- erosive sx

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14
Q

Schnyder’s dystrophy

A
bilteral
opacity
accumulation of lipids and cholesterol
slow progression
need corneal transplant
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15
Q

congenital heredity endotheial dystrophy

A
infancy 
cloudy cornea
photophobia
tearing
nystagmus?
DD- congenital conrea
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16
Q

Congenital clouding of the cornea

A
STUMPED you stumped?
S - Sclerocornea
T - Tears in the Descemet membrane secondary to birth trauma or congenital glaucoma
U - Ulcers
M - Metabolic
P - Peters anomaly
E - Edema (CHED)
D – Dermoid
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17
Q

corneal dystrophy

A

primary bilateral disorder
young px?
check which layers of the cornea is involved
pattern sx

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18
Q

keratoconus- irregular k values

A
non-inflammatory
stromal thinning- distortion
cornea thins and protrudes
progresses slowly over 10-20 years
sx- frequent changes of glasses/cl
blurring/ distortion
glare
monocular diplopia
photophobia
eye rubbing
FLEICHERS ring- iris position
vogts stress striae line
munsons sign- when u look down- v shape

TREAT WITH - RGP
cornela rings
corneal transplant

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19
Q

Keratoglobus

A

rare- thinning
protrusion of entire cornea
non progressive
may result in corneal rupture!!!!!!!!!!!!

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20
Q

Pellucid marginal degeneration

A

bilateral
slow progressive crescent shaped area of interior corneal thinning
protrusion is above the are of thinning
DD with keratoconus

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21
Q

Iridocorneal endothelial syndrome

A

chandlers syndrome- only silver appearance

cogan-reese syndrome- pigmnted noduules of iris

essential iris atrophy- striate an melt holes, posterio
angle pysniki

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22
Q

Corneal degeneration occur later in life. Not born with these

A

Lipid keratopathy
Band keratopathy
Salzmann nodular degeneration

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23
Q

Arcus senilis

A

white circle around periphery of iris- deposits of fatty material i cornea

24
Q

Band keratopathy

A

calcium deposits in a band across the cornea
caused by: chronic uveitis, glaucoma, hypercalcimia, phtisis bulbi

need surgical debridment

25
Dellen
tear film instability- corneal instbaility | caused by strabismus, surgery, glaucoma, RGP
26
corneal abrasions - most common
History of trauma intense pain/photphobia red eye epithelial loss with Fl
27
small abrasion- usualy manages out patent
``` cylopegia antibiotics double pad could have complications- recurrent/ infection not generally referred ```
28
persistent epithelial defect
corneas affected by other diseases lubrication needed treat infection bandage cl? graft?
29
recurrent corneal erosion
``` disturbance of epithelial membrane pain on waking, UNILATERAL lacrimation/ photophobia central cornreal abrasion with large epithelial flaps bownish odeama in anterior stroma secondary to corneal injury/ spontaneous?? in diabetics ``` ``` MANAGEMENT_ repair epithelium resolve spontaneously? lubrication for 6 weeks pressure patch bandage cl phototheraputic keratectomy ```
30
MK- marginal keratitis
staphylocoi exotoxin- hypersensitivty reaction subepithleila infiltrate near limbus/ ulcer treat with antibiotics, good lid hygiene, cyclopegia, steroids
31
Terrien’s marginal degeneration\ | peripheral thinning- in med
bilateral thinning of peripheral cornea neovas? treatment- lamella kp painless blurred vision
32
mooreens ulcer
idiopathic peripheral ulcer caused by ischeamic necrosis progresses centrally, centrifugally and posteriotlu complains of ExtrEME pain responds to agressive steroid/ immunoresponsice chemotherapy
33
Peripheral corneal melt
caused by rheumatoid arthritis, lupus and other systemic disease resorption of peripheral cornea treatment with steroids and kerotoplasty
34
corneal infections- bacterial/viral
risk factors: Mechanical or chemical damage of the epithelium Extended-wear soft C/L Other ocular infections and dry eye Debilitation and nutritional deficiency Cancer, AIDS Administration of topical and systemic immunosuppressive agents
35
sx of
Rapidly reducing vision Pain | Photophobia Conjunctival injection Discharge
36
examination
Epithelial ulceration Stromal suppuration/ abscess Diffuse epithelial oedema Stromal infiltrate Endothelial plaque Hypopyon
37
diagnosis of keratits based on H+S
``` istory Contact lens Trauma Previous surgery Pre-existing ocular diseases Urban/ rural Topical and systemic medication Examination ``` we need to identify pathogen and its sensitivity to antibiotics we need corneal scrapings- Green needle Surgical blade Sterile spatula admit to hosp- if no bacteria iddentified- then give broad spectrum antibody
38
how do u know if antibiotic therapy is working in bacterial keratits
``` Blunting of the perimeter of the stromal infiltrate – ↓ density of the stromal infiltrate – ↓ stromal oedema and endothelial inflammatory plaque – ↓ anterior chamber inflammation – Reepithelialization of defect – Improvement in painful symptoms   No response to therapy Compliance/????? What did the lab grow- is he treatment effecting this Is the diagnosis correct- Stop the treatment Re-scrape Biopsy Toxicity from drops ```
39
adeno virus herpes simplex herpes zoster
viral keratitis
40
adeno virus
``` follicular conductiva pain/ photophobia glands/ unwell/va loss no treatment steroids? ```
41
herpes simplex
pain photophobia lacrimation
42
HERPES SIMPLEX | Dendridic ulcer
single/multiple linear branches- ed in beadlike extensions stromal infiltrate diminished corneal sensitivity
43
HERPES SIMPLEX | Geographic ulcer
HSV treated by steroids
44
how do u treat herpes simplex | with dendritrs/ geographical ulcer
- Debridement - Topicalantivirals - Cycloplegia - OralAcyclovir
45
Metaherpetic ulceration with herpes simplex
``` recurrent episodes of heretic keratitis recurrent corneal ersions persistent ulceration eluting of the aroma stromal scarring lubrication, antibiotic, antiviral drops ```
46
Stromal keratitis | and herpes simplex
``` hyspersensitivity srtomal odeama KP irits scarring treat with topical steroids?? ```
47
herpes zoster
``` 5th cranial nerve previous influence? dermatol pain? skin changes, respecting midline involving tip of nose- hutchinsons sign blepharitis and conjunctivitis ```
48
stromal keratitis-
in herpes zoster
49
ocular manifestations of herpes zoster
``` Ophthalmoplegia Uveitis Episcleritis and scleritis Retinal necrosis Postherpetic neuralgia and other neurologic complications ```
50
treatment of HZO
Oral Acyclovir Topical lubrication and antibiotics for blepharitis and conjunctivitis Epithelial keratitis: debridement, topical antibiotics Stromal & intraocular disease: steroids Local and systemic analgesics for pain Antidepressants for post herpetic neuralgia
51
fungal keratitis
ocualr consequences anti fungal therapys fungi proliferate within corneal tissue and to resis host defence fungal corneal infections spread- to stroma- to ac
52
what does fungal keratits look like
yellow-white or greyish- white ulcer with indistinct margins Dense suppuration Satellite lesions, ring infiltrate, hypopyon
53
how would u manage fungal keratits
Corneal scrapping and biopsy Topical and systemic antifungal agents Daily scrapping Penetrating keratoplasty No steroids
54
Acanthamoeba Keratitisamoeba from
water, soil, sludge, dust use of cl? dendriform lesions unlcerations/ infiltrates an opacification of cornea???
55
characteristics of acanthomeabe keratitis
Elevated epithelial lesions Dendritiform lesions Sub-epithelial infiltrates Radial keratoneuritis Patchy stromal infiltrates Ring infiltrates Sclero-keratitis
56
Diagnosis and management of fungal keratits
needs to be confirmed b lab corneal biopsy? multi frug therapy painkillers