Flashcards in Corneal Repair Deck (27):
connects cells and extracellular matrix
forms intercellular junctions
sense change in extracellular environment
fascilitate cellular communication between cells and surrounding tissues
control growth of corneal cells
promote proliferation of corneal cells
starts migration of cells
Layers of Epithelium
Layer for Epithelial Cell Replication
How long is the cell turnover of the epithelium?
Initiate repair of corneal epithelium
growth factors and cytokines
released from damaged cells
Change in cytoskeleton during healing
cell shape changes
cells at wound edges develop membrane extensions
cells migrate to cover wound
Cell Migration requires....
cell to matrix adhesion
preserves integrity of epithelium
allow for epithelium to stick to Bowman's
pulls cells forward to cover wound
Prevents Epithelial Hyperplasia during wound healing
Healing time of a small lesion
24 - 48 hrs
Healing time if basement membrane is damaged
Recurrent Corneal Erosion
epithelium sloughs off
from poor adhesion b/t epithelium and basement membrane or b/t BM and stroma
Recurrent Corneal Erosion occurs when?
after incomplete healing of abrasion
epithelial basement membrane dystrophy
Treating Recurrent Corneal Erosion
artificial tears, antibiotics, bandage
anterior stromal micropuncture, superficial or phototherapeutic keratectomy
composed of collagen
highly resistant to damage; does not regen
Replaces lost Bowman's cells
stromal scar tissue or epithelium
extracellular ground substance
Why is the stroma likely to scar?
new collagen fibers are larger and their organization is not as precise
Time frame to heal stroma
takes longer for new collagen to get to full strength
basement membrane of endothelium
made of collagen
Where does Descemet's membrane regenerate from?
stromal keratocytes and endothelium
Layers to Endothelium
Basal part of Endothelium faces.....
Apical part of Endothelium faces....