Flashcards in Coronary Artery disease Deck (22)
What is chronic stable Angina?
Chest tightness, pain, and shortness of breath upon exertion, usually in the elderly
What is the cause of Chronic Stable Angina
A problem of supply and demand i.e the supply of blood and oxygen is inadequate for myocardial demand
What factors determine demand?
What is the Treadmill test?
To check effects of exertion on patients
What are symptoms of acute coronary syndrom?
Patients complain of elephant sitting on their chest usually wakes them up while asleep
What is the pathophysiology of acute coronary syndrome?
Rupture of Atherosclerotic plaque (in coronary artery) which causes most importantly:
1.Constriction of Coronary Artery
2.Blood clots form (Thrombotic state)
What is not present in Acute coronary syndrome?
Mismatch of supply and demand
What is the cause of an ST elevation in MI?
100% occlusion of a coronary artery
What is the immediate course of action in a patient presenting with ST elevation MI?
Get them to Cath Lab ASAP
What are the determinants of Myocardial O2 demand?
What is always associated with Angina Pectoris?
1.Sympathetic Overdrive/increased Catecholamine release
2.Patients become PALE
What distinguishes an ST elevation acute MI from Acute coronary syndrome?
1.The ST elevation on ECG
2.Lack of complete occlusion of the artery
What are the factors that could lead to rupture of Atherosclerotic plaque?
What are the characteristics of Plaques which tend to rupture?
1.Large Lipid core
2.Not well formed
4.Lots of Macrophages present
5.Low smooth muscle cell count
What Blood cells play an integral role in ACS?
What class of Drugs play an important role in treatment of ACS?
What new class of drugs are showing great promise in targeting Platelet agreggation in ACS?
Where does the pain normally radiate to in ACS?
Arm, Neck, Jaw, Epigastrium or between scapulae
What are some of the common complications of MI?
-Free Wall Of Ventricle
Essentially is abnormal accumulation of Salt and water in the alveoli
What is the function of Streptokinase in patients suffering from MI?
It dissolves the clots which may be causing the occlusion