Coronary Artery disease Flashcards Preview

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Flashcards in Coronary Artery disease Deck (22):
1

What is chronic stable Angina?

Chest tightness, pain, and shortness of breath upon exertion, usually in the elderly

2

What is the cause of Chronic Stable Angina

A problem of supply and demand i.e the supply of blood and oxygen is inadequate for myocardial demand

3

What factors determine demand?

1.Sytolic BP
2.HR

4

What is the Treadmill test?

To check effects of exertion on patients

5

What are symptoms of acute coronary syndrom?

Patients complain of elephant sitting on their chest usually wakes them up while asleep

6

What is the pathophysiology of acute coronary syndrome?

Rupture of Atherosclerotic plaque (in coronary artery) which causes most importantly:
1.Constriction of Coronary Artery
2.Blood clots form (Thrombotic state)

7

What is not present in Acute coronary syndrome?

Mismatch of supply and demand

8

What is the cause of an ST elevation in MI?

100% occlusion of a coronary artery

9

What is the immediate course of action in a patient presenting with ST elevation MI?

Get them to Cath Lab ASAP

10

What are the determinants of Myocardial O2 demand?

1.Sytolic BP
2.HR

11

What is always associated with Angina Pectoris?

1.Sympathetic Overdrive/increased Catecholamine release
2.Patients become PALE
3.Diaphoresis

12

What distinguishes an ST elevation acute MI from Acute coronary syndrome?

1.The ST elevation on ECG
2.Lack of complete occlusion of the artery

13

What are the factors that could lead to rupture of Atherosclerotic plaque?

1.Diabetes (Glucose)
2.Smoking
3.Hypertension
4.Hypercholestrolemia (Lipoproteins)
5.Turbulent flow
6.Oxygen ROS
8.Cytokines

14

What are the characteristics of Plaques which tend to rupture?

1.Large Lipid core
2.Not well formed
3.Thin Cap
4.Lots of Macrophages present
5.Low smooth muscle cell count

15

What Blood cells play an integral role in ACS?

Platelets

16

What class of Drugs play an important role in treatment of ACS?

Blood thinners

17

What new class of drugs are showing great promise in targeting Platelet agreggation in ACS?

GpIIb/IIIa inhibitors

18

Where does the pain normally radiate to in ACS?

Arm, Neck, Jaw, Epigastrium or between scapulae

19

What are some of the common complications of MI?

1.Necrosis
2.Myocardial Rupture
-Free Wall Of Ventricle
-Interventricular Septum
-Papillary Muscle

20

CHF

Essentially is abnormal accumulation of Salt and water in the alveoli

21

What is the function of Streptokinase in patients suffering from MI?

It dissolves the clots which may be causing the occlusion

22

When is Streptokinase contraindicated?

1.Recent CVA (within 2 months), Intracranial or Intraspinal bleeding
2.Active Internal Bleeding
3.Intracranial Neoplasm
4.Puncture of Noncompressible artery