Corticosteroids

Question 1

2 types of corticosteroids

Answer 1

1. mineralocorticoids- aldosterone

2. glucocorticoids- cortisol

Question 2

What are the 4 effects of cortisol/ hydrocortisone?

Answer 2

1. metabolic
2. catabolic
3. feedback inhibition
4. miscellaneous effects

Question 3

Actions of steroids

Answer 3

1. decreasing circulating T/B cells, monocytes, eosinophils, basophils
2. increase neutrophils by decreasing extravasation & increased prdn
3. decrease size & lymphoid content of lymph nodes
4. increase macrophage efferocytosis, resolution of inflammation
5. decrease type IV delayed hypersensitivity
6. more effects on cellular than humoral immunity

1st line in SOT/HSC transplant

Question 4

Name all the steroids

Answer 4

1. Cortisol
   Hydrocortisone

Prednisone
Prednisolone
Methylprednisolone
Triamcinolone

Betamethasone
Dexmethasone

Question 5

DOA
glucocorticoid anti-inflamm effect
water retention effect (mineralocorticoid)

Answer 5

DOA
8-12 hr
12-36 hr
24-72 hr

GE
1, 0.8
4,5,5,5
25-40,30 (most potent beta & dexa)

WRE
1, 0.8
0.3,0.3,00
00

Question 6

DOA
glucocorticoid anti-inflamm effect
water retention effect (mineralocorticoid)

Answer 6

DOA
8-12 hr
12-36 hr
24-72 hr

GE
1, 0.8
4,5,5,5
25-40,30 (most potent beta & dexa)

WRE
1, 0.8
0.3,0.3,00 (prednisone & prednisolone)
00

Question 7

Side effects of steroids

Answer 7

1. MSK
2. immune
3. eye
4. GIT
5. CNS
6. Withdrawal phenomenon
7. glucocorticoids resistance